Protein detail

TXNIP

Thioredoxin-interacting protein (Thioredoxin-binding protein 2) (Vitamin D3 up-regulated protein 1)

Entry name TXNIP	UniProt ID Q9H3M7	EVMP confidence score 0.38
Supporting publications (n) 2	Transmembrane count	Protein classification Cancer-related genesPredicted intracellular proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Thioredoxin-interacting protein (Thioredoxin-binding protein 2) (Vitamin D3 up-regulated protein 1)

Protein Class (3)

Cancer-related genesPredicted intracellular proteinsTransporters

Protein Function (3)

Cancer-related genes:Mutational cancer driver genes
Predicted intracellular proteins
Transporters:Accessory Factors Involved in Transport

Ensembl

ENSG00000265972

Entrez Gene Symbol

TXNIP

Gene Synonym (5)

ARRDC6EST01027HHCPA78THIFVDUP1

Gene Description

Thioredoxin interacting protein

Chromosome

Position

145992435-145996579

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization1

Function & Pathway7

Protein Function (3)

Cancer-related genes:Mutational cancer driver genes
Predicted intracellular proteins
Transporters:Accessory Factors Involved in Transport

Cellular Component (2)

Molecular Function (3)

Biological Process (3)

KEGG

hsa04621 NOD-like receptor signaling pathway

Reactome (13)

Page 1 of 2

Mediation Categories (2)

Clinical-translation mediationImmune mediation

Relations & Evidence18

Enzyme-Mediated Modification (3)

3 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database
TXNIP	PRKAA1	Q13131	S	308	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper
TXNIP	MAPK14	Q16539	S	361	phosphorylation	PhosphoSite
TXNIP	MAPK1	P28482	T	349	phosphorylation	PhosphoSite

Ligand-Receptor Signaling (5)

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network (4)

4 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
MK01	P28482	TXNIP	Q9H3M7	Yes	No	Yes	SIGNORPhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:30410860 SIGNOR:31320475 PhosphoSite:31320475
	COMPLEX:O43741_P54619_P54646_Q13131_Q9UGI9_Q9UGJ0_Q9Y478	TXNIP	Q9H3M7	Yes	No	Yes	SIGNOR	SIGNOR:23453806
TXNIP	Q9H3M7	DDIT4	Q9NX09	Yes	Yes	No	SIGNOR	SIGNOR:21460850
AAPK1	Q13131	TXNIP	Q9H3M7	Yes	No	No	PhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:23453806

Protein Complex Composition (5)

5 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
TXN TXNIP	P10599 Q9H3M7	2:2	PDB	PDB:4ll1PDB:4ll4
TXNIP VAV2	P52735 Q9H3M7	3:3	PDB	PDB:4roj
PTPN11 TXNIP	Q06124 Q9H3M7	1:2	PDB	PDB:5df6
ITCH TXNIP	Q96J02 Q9H3M7	2:2	PDB	PDB:5dwsPDB:4rofPDB:5cq2PDB:5dzd
TXNIP	Q9H3M7	10	PDB	PDB:4gej

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	30805606

Sequence, Structure & Domains10

Sequences

Length

391

Mass

43,661

Sequence

MVMFKKIKSFEVVFNDPEKVYGSGEKVAGRVIVEVCEVTRVKAVRILACGVAKVLWMQGSQQCKQTSEYLRYEDTLLLEDQPTGENEMVIMRPGNKYEYKFGFELPQGPLGTSFKGKYGCVDYWVKAFLDRPSQPTQETKKNFEVVDLVDVNTPDLMAPVSAKKEKKVSCMFIPDGRVSVSARIDRKGFCEGDEISIHADFENTCSRIVVPKAAIVARHTYLANGQTKVLTQKLSSVRGNHIISGTCASWRGKSLRVQKIRPSILGCNILRVEYSLLIYVSVPGSKKVILDLPLVIGSRSGLSSRTSSMASRTSSEMSWVDLNIPDTPEAPPCYMDVIPEDHRLESPTTPLLDDMDGSQDSPIFMYAPEFKFMPPPTYTEVDPCILNNNVQ

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H3M7-1; Sequence=Displayed; Name=2; IsoId=Q9H3M7-2; Sequence=VSP_054401

Alternative Sequence

1..83; MVMFKKIKSFEVVFNDPEKVYGSGEKVAGRVIVEVCEVTRVKAVRILACGVAKVLWMQGSQQCKQTSEYLRYEDTLLLEDQPT -> MPPKHSLSHRCILSVTASLMATRFSFPS (in isoform 2)

3D Structural Models

Helix

334..337

Beta Strand

8..16; 20..22; 26..34; 39..41; 43..58; 61..76; 79..81; 83..85; 89..91; 93..95; 97..104; 111..114; 116..130; 137..142; 144..146; 148..150; 160..167; 177..185; 187..190; 194..203; 205..207; 209..223; 226..238; 246..256; 269..281; 288..298

3D Structure

X-ray crystallography (11)

Domain & Motif Annotations

Protein Families

Arrestin family

Sequence Similarities

Belongs to the arrestin family.

Clinical Relevance6

Disease Involvement (2)

Cancer-related genesTumor suppressor

Drugs

RECOMBINANT FAS LIGAND

Antibody (2)

HPA031085 HPA053694

Interaction Protein (3)

ENSG00000122882ENSG00000136810ENSG00000196591

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications2

PMID	Title	Abstract
36347401	Exosome proteomics study of the effects of traditional cigarettes and electronic cigarettes on human bronchial epithelial cells.	In this study, we evaluated the cytotoxicities of e-Cig and t-Cig condensate solutions (e-CigCS and t-CigCS) on human bronchial epithelial cells (16HBE cells) in vitro, and employed the exosome proteomic technique to systematically assess the effects of e-CigCS and t-CigCS on 16HBE cells.
37154070	CIRC_0001818 TARGETS MIR-136-5P TO INCREASE LIPOPOLYSACCHARIDE-INDUCED HK2 CELL INJURIES BY ACTIVATING TXNIP/NLRP3 INFLAMMASOME PATHWAY.	The receiver operating characteristic curve was depicted to assess the diagnostic value of circ_0001818, miR-136-5p, and TXNIP in serumal exosomes from patients with septic AKI.