Protein detail
SMOC1
SPARC-related modular calcium-binding protein 1 (Secreted modular calcium-binding protein 1) (SMOC-1)
Entry name SMOC1 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 2 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPredicted secreted proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information10
Protein Names
SPARC-related modular calcium-binding protein 1 (Secreted modular calcium-binding protein 1) (SMOC-1)
Protein Class (3)
Disease related genesHuman disease related genesPredicted secreted proteins
Protein Function (3)
- Disease related genes
- Predicted secreted proteins
- Human disease related genes:Congenital malformations:Other congenital malformations
Ensembl
Entrez Gene Symbol
Gene Description
SPARC related modular calcium binding 1
Chromosome
14
Position
69854131-70032366
Supporting publications (n)
2
EVMP confidence score
0.50
Fluorescence & Localization3
Cell SpecificBergmann gliaSingle-Nuclei Brain Specificoligodendrocyte precursor cell
Function & Pathway5
Protein Function (3)
- Disease related genes
- Predicted secreted proteins
- Human disease related genes:Congenital malformations:Other congenital malformations
Cellular Component (2)
Molecular Function (4)
Biological Process (3)
Mediation Categories
Other mediation
Relations & Evidence19
Ligand-Receptor Signaling (18)
18 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| secreted | secreted | UniProt_keyword | No | No | Yes | No | No |
| secreted | secreted | UniProt_location | No | No | Yes | No | No |
| secreted | secreted | HPA_secretome | No | No | Yes | No | No |
| secreted | secreted | OmniPath | No | No | Yes | No | No |
| glycoprotein | ecm | Matrisome | Yes | No | Yes | No | No |
| ligand | ligand | ICELLNET | Yes | No | Yes | No | No |
| ligand | ligand | OmniPath | Yes | No | Yes | No | No |
| sparc_ecm_regulator | sparc_ecm_regulator | HGNC | No | No | Yes | No | No |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 34889606 |
Sequence, Structure & Domains8
Sequences
Length
434
Mass
48,163
Sequence
MLPARCARLLTPHLLLVLVQLSPARGHRTTGPRFLISDRDPQCNLHCSRTQPKPICASDGRSYESMCEYQRAKCRDPTLGVVHRGRCKDAGQSKCRLERAQALEQAKKPQEAVFVPECGEDGSFTQVQCHTYTGYCWCVTPDGKPISGSSVQNKTPVCSGSVTDKPLSQGNSGRKDDGSKPTPTMETQPVFDGDEITAPTLWIKHLVIKDSKLNNTNIRNSEKVYSCDQERQSALEEAQQNPREGIVIPECAPGGLYKPVQCHQSTGYCWCVLVDTGRPLPGTSTRYVMPSCESDARAKTTEADDPFKDRELPGCPEGKKMEFITSLLDALTTDMVQAINSAAPTGGGRFSEPDPSHTLEERVVHWYFSQLDSNSSNDINKREMKPFKRYVKKKAKPKKCARRFTDYCDLNKDKVISLPELKGCLGVSKEGRLV
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H4F8-1; Sequence=Displayed; Name=2; IsoId=Q9H4F8-2; Sequence=VSP_008720
Alternative Sequence
430; E -> EV (in isoform 2)
Domain & Motif Annotations
Compositional Bias
149..172; Polar residues
Domain (FT)
37..89; Kazal-like; 92..158; Thyroglobulin type-1 1; 224..292; Thyroglobulin type-1 2; 359..394; EF-hand 1; 396..431; EF-hand 2
Region
149..191; Disordered
Clinical Relevance2
Supporting Publications2
| PMID | Title | Abstract |
|---|---|---|
| 37922300 | Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women. | No abstract available |
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No abstract available |