Protein detail
PKHA4
Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1)
Entry name PKHA4 | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 4 | Transmembrane count | Protein classification Predicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
PEPP1
Gene Description
Pleckstrin homology domain containing A4
Chromosome
19
Position
48837092-48868617
Supporting publications (n)
4
EVMP confidence score
0.40
Fluorescence & Localization
Tissue SpecificbrainSingle-Nuclei Brain SpecificBergmann glia
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (3)
Molecular Function (6)
Reactome (4)
Mediation Categories (2)
Metabolism mediationReceptor-signaling mediation
Relations & Evidence6
Ligand-Receptor Signaling (4)
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath |
Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture | Mass spectrometryWestern blotting | 32 | 34889606389386743929045923376485265384823150850034675683944354437702715327954142956273528562335247008642353145254712072680191928242843300713183060870032927759335802653372925522106071224189803663540037686366400983464120109034131392307605384031161641315767 |
Sequence, Structure & Domains
Sequences
Length
779
Mass
85,401
Sequence
MEGSRPRSSLSLASSASTISSLSSLSPKKPTRAVNKIHAFGKRGNALRRDPNLPVHIRGWLHKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPRGRRFTFTAEHPGMRTYVLAADTLEDLRGWLRALGRASRAEGDDYGQPRSPARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQAHSGSPTYLQLPPRPPGTRASMVLLPGPPLESTFHQSLETDTLLTKLCGQDRLLRRLQEEIDQKQEEKEQLEAALELTRQQLGQATREAGAPGRAWGRQRLLQDRLVSVRATLCHLTQERERVWDTYSGLEQELGTLRETLEYLLHLGSPQDRVSAQQQLWMVEDTLAGLGGPQKPPPHTEPDSPSPVLQGEESSERESLPESLELSSPRSPETDWGRPPGGDKDLASPHLGLGSPRVSRASSPEGRHLPSPQLGTKAPVARPRMSAQEQLERMRRNQECGRPFPRPTSPRLLTLGRTLSPARRQPDVEQRPVVGHSGAQKWLRSSGSWSSPRNTTPYLPTSEGHRERVLSLSQALATEASQWHRMMTGGNLDSQGDPLPGVPLPPSDPTRQETPPPRSPPVANSGSTGFSRRGSGRGGGPTPWGPAWDAGIAPPVLPQDEGAWPLRVTLLQSSF
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H4M7-1; Sequence=Displayed; Name=2; IsoId=Q9H4M7-2; Sequence=VSP_009770, VSP_009771, VSP_009772
Alternative Sequence
325..349; Missing (in isoform 2); 582..608; APVARPRMSAQEQLERMRRNQECGRPF -> SKEHHPLLADFRRSPGAGSQPLPSPGY (in isoform 2); 609..779; Missing (in isoform 2)
3D Structural Models
Helix
101..103; 138..152
Beta Strand
55..64; 66..69; 72..80; 83..89; 97..100; 105..108; 116..124; 131..134
3D Structure
X-ray crystallography (3)
Domain & Motif Annotations
Compositional Bias
184..193; Basic and acidic residues; 315..332; Polar residues; 525..535; Low complexity; 536..551; Basic and acidic residues; 594..603; Basic and acidic residues; 647..663; Polar residues; 704..724; Pro residues
Domain (FT)
54..153; PH
Region
152..352; Disordered; 492..670; Disordered; 691..764; Disordered
Supporting Publications4
| PMID | Title | Related sentences |
|---|---|---|
| 28986585 | Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics. | No related sentences available |
| 33204424 | Proteomic analysis of extracellular vesicles reveals an immunogenic cargo in rheumatoid arthritis synovial fluid. | No related sentences available |
| 34817906 | Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform. | No related sentences available |
| 37786918 | Rapid and in-depth proteomic profiling of small extracellular vesicles for ultralow samples. | No related sentences available |