Protein detail

PIEZ2

Piezo-type mechanosensitive ion channel component 2 (Protein FAM38B)

Entry name PIEZ2	UniProt ID Q9H5I5	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 38	Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Piezo-type mechanosensitive ion channel component 2 (Protein FAM38B)

Protein Class (6)

Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function (5)

Predicted intracellular proteins
Potential drug targets
Transporters:Transporter channels and pores
Disease related genes
Human disease related genes:Congenital malformations:Other congenital malformations

Transmembrane

13..24; Helical; Name=1; 31..43; Helical; Name=2; 51..76; Helical; Name=3; 123..141; Helical; Name=4; 222..237; Helical; Name=5; 241..258; Helical; Name=6; 265..287; Helical; Name=7; 336..355; Helical; Name=8; 493..514; Helical; Name=9; 520..531; Helical; Name=10; 536..562; Helical; Name=11; 584..614; Helical; Name=12; 686..699; Helical; Name=13; 706..724; Helical; Name=14; 734..753; Helical; Name=15; 786..807; Helical; Name=16; 941..956; Helical; Name=17; 963..972; Helical; Name=18; 981..1001; Helical; Name=19; 1058..1082; Helical; Name=20; 1124..1138; Helical; Name=21; 1141..1154; Helical; Name=22; 1166..1185; Helical; Name=23; 1223..1243; Helical; Name=24; 1298..1310; Helical; Name=25; 1317..1329; Helical; Name=26; 1339..1364; Helical; Name=27; 1414..1430; Helical; Name=28; 1922..1936; Helical; Name=29; 1944..1955; Helical; Name=30; 1962..1983; Helical; Name=31; 2017..2035; Helical; Name=32; 2190..2209; Helical; Name=33; 2232..2252; Helical; Name=34; 2257..2280; Helical; Name=35; 2290..2312; Helical; Name=36; 2398..2421; Helical; Name=37; 2670..2690; Helical; Name=38

Transmembrane Count

Ensembl

ENSG00000154864

Entrez Gene Symbol

PIEZO2

Gene Synonym (9)

C18orf30C18orf58FAM38BFAM38B2FLJ23144FLJ23403FLJ34907HsT748HsT771

Gene Description

Piezo type mechanosensitive ion channel component 2

Chromosome

Position

10666483-11149569

Supporting publications (n)

EVMP confidence score

0.50

Function & Pathway5

Protein Function (5)

Predicted intracellular proteins
Potential drug targets
Transporters:Transporter channels and pores
Disease related genes
Human disease related genes:Congenital malformations:Other congenital malformations

Cellular Component (4)

Molecular Function (3)

Biological Process (3)

Mediation Categories

Fusion and delivery mediation

Relations & Evidence19

Ligand-Receptor Signaling (17)

17 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
ion_channel	ion_channel	DGIdb	No	Yes	No	No	No
transporter	transporter	OmniPath	No	Yes	No	No	No
ion_channel	ion_channel	OmniPath	No	Yes	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No

Page 1 of 2Next

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
Hair cells mechanotransduction channel	PIEZO1 PIEZO2 TMC1 TMC2	Q8TDI7 Q8TDI8 Q92508 Q9H5I5	0:0:0:0	SIGNOR	SIGNOR:SIGNOR-C290

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry；RNA Sequencing；Flow cytometry	1	41307968

Sequence, Structure & Domains10

Sequences

Length

2,752

Mass

318,064

Sequence

MASEVVCGLIFRLLLPICLAVACAFRYNGLSFVYLIYLLLIPLFSEPTKTTMQGHTGRLLKSLCFISLSFLLLHIIFHITLVSLEAQHRIAPGYNCSTWEKTFRQIGFESLKGADAGNGIRVFVPDIGMFIASLTIWLLCRNIVQKPVTDEAAQSNPEFENEELAEGEKIDSEEALIYEEDFNGGDGVEGELEESTKLKMFRRLASVASKLKEFIGNMITTAGKVVVTILLGSSGMMLPSLTSSVYFFVFLGLCTWWSWCRTFDPLLFSCLCVLLAIFTAGHLIGLYLYQFQFFQEAVPPNDYYARLFGIKSVIQTDCSSTWKIIVNPDLSWYHHANPILLLVMYYTLATLIRIWLQEPLVQDEGTKEEDKALACSPIQITAGRRRSLWYATHYPTDERKLLSMTQDDYKPSDGLLVTVNGNPVDYHTIHPSLPMENGPGKADLYSTPQYRWEPSDESSEKREEEEEEKEEFEEERSREEKRSIKVHAMVSVFQFIMKQSYICALIAMMAWSITYHSWLTFVLLIWSCTLWMIRNRRKYAMISSPFMVVYGNLLLILQYIWSFELPEIKKVPGFLEKKEPGELASKILFTITFWLLLRQHLTEQKALQEKEALLSEVKIGSQENEEKDEELQDIQVEGEPKEEEEEEAKEEKQERKKVEQEEAEEEDEQDIMKVLGNLVVAMFIKYWIYVCGGMFFFVSFEGKIVMYKIIYMVLFLFCVALYQVHYEWWRKILKYFWMSVVIYTMLVLIFIYTYQFENFPGLWQNMTGLKKEKLEDLGLKQFTVAELFTRIFIPTSFLLVCILHLHYFHDRFLELTDLKSIPSKEDNTIYRLAHPEGSLPDLTMMHLTASLEKPEVRKLAEPGEEKLEGYSEKAQKGDLGKDSEESEEDGEEEEESEEEEETSDLRNKWHLVIDRLTVLFLKFLEYFHKLQVFMWWILELHIIKIVSSYIIWVSVKEVSLFNYVFLISWAFALPYAKLRRLASSVCTVWTCVIIVCKMLYQLQTIKPENFSVNCSLPNENQTNIPFNELNKSLLYSAPIDPTEWVGLRKSSPLLVYLRNNLLMLAILAFEVTIYRHQEYYRGRNNLTAPVSRTIFHDITRLHLDDGLINCAKYFINYFFYKFGLETCFLMSVNVIGQRMDFYAMIHACWLIAVLYRRRRKAIAEIWPKYCCFLACIITFQYFICIGIPPAPCRDYPWRFKGASFNDNIIKWLYFPDFIVRPNPVFLVYDFMLLLCASLQRQIFEDENKAAVRIMAGDNVEICMNLDAASFSQHNPVPDFIHCRSYLDMSKVIIFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGDLLLKPIKSILRYWDWLIAYNVFVITMKNILSIGACGYIGTLVHNSCWLIQAFSLACTVKGYQMPAANSPCTLPSGEAGIIWDSICFAFLLLQRRVFMSYYFLHVVADIKASQILASRGAELFQATIVKAVKARIEEEKKSMDQLKRQMDRIKARQQKYKKGKERMLSLTQEPGEGQDMQKLSEEDDEREADKQKAKGKKKQWWRPWVDHASMVRSGDYYLFETDSEEEEEEELKKEDEEPPRRSAFQFVYQAWITDPKTALRQRHKEKKRSAREERKRRRKGSKEGPVEWEDREDEPIKKKSDGPDNIIKRIFNILKFTWVLFLATVDSFTTWLNSISREHIDISTVLRIERCMLTREIKKGNVPTRESIHMYYQNHIMNLSRESGLDTIDEHPGAASGAQTAHRMDSLDSHDSISSEPTQCTMLYSRQGTTETIEEVEAEQEEEAGSTAPEPREAKEYEATGYDVGAMGAEEASLTPEEELTQFSTLDGDVEAPPSYSKAVSFEHLSFGSQDDSAGKNRMAVSPDDSRTDKLGSSILPPLTHELTASELLLKKMFHDDELEESEKFYVGQPRFLLLFYAMYNTLVARSEMVCYFVIILNHMVSASMITLLLPILIFLWAMLSVPRPSRRFWMMAIVYTEVAIVVKYFFQFGFFPWNKNVEVNKDKPYHPPNIIGVEKKEGYVLYDLIQLLALFFHRSILKCHGLWDEDDMTESGMAREESDDELSLGHGRRDSSDSLKSINLAASVESVHVTFPEQQTAVRRKRSGSSSEPSQRSSFSSNRSQRGSTSTRNSSQKGSSVLSIKQKGKRELYMEKLQEHLIKAKAFTIKKTLEIYVPIKQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADITSSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVILVFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKVVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVINQPLDVSVTITLGGYQPIFTMSAQQSQLKVMDQQSFNKFIQAFSRDTGAMQFLENYEKEDITVAELEGNSNSLWTISPPSKQKMIHELLDPNSSFSVVFSWSIQRNLSLGAKSEIATDKLSFPLKNITRKNIAKMIAGNSTESSKTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENNFMDITIILSRDNTTKYNSEWWVLNLTGNRIYNPNSQALELVVFNDKVSPPSLGFLAGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTREKTN

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9H5I5-1; Sequence=Displayed; Name=2; IsoId=Q9H5I5-2; Sequence=VSP_040472; Name=3; IsoId=Q9H5I5-3; Sequence=VSP_040471; Name=4; IsoId=Q9H5I5-4; Sequence=VSP_040630

Alternative Sequence

1..2043; Missing (in isoform 3); 831; R -> SHAKVNGRVYLIINSIKKKLPIHQNE (in isoform 4); 2387..2449; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

463..474; Acidic residues; 623..632; Acidic residues; 649..660; Basic and acidic residues; 862..883; Basic and acidic residues; 884..902; Acidic residues; 1594..1615; Basic residues; 2100..2127; Low complexity

Coiled Coil

1458..1529

Region

446..478; Disordered; 623..664; Disordered; 862..902; Disordered; 1488..1534; Disordered; 1593..1636; Disordered; 1844..1868; Disordered; 2047..2069; Disordered; 2090..2135; Disordered

Protein Families

PIEZO (TC 1.A.75) family

Sequence Similarities

Belongs to the PIEZO (TC 1.A.75) family.

Clinical Relevance2

Disease Involvement

Disease variant

Antibody (3)

HPA015986 HPA031974 HPA040616

Supporting Publications1

PMID	Title	Abstract
21630462	Proteomic analysis of microvesicles derived from human colorectal cancer ascites.	No abstract available