Protein detail
SLIK6
SLIT and NTRK-like protein 6
Entry name SLIK6 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 2 | Transmembrane count 1 | Protein classification Disease related genesHuman disease related genesPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
SLIT and NTRK-like protein 6
Protein Class (3)
Disease related genesHuman disease related genesPredicted membrane proteins
Protein Function (2)
- Disease related genes
- Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
Transmembrane
609..629; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
FLJ22774
Gene Description
SLIT and NTRK like family member 6
Chromosome
13
Position
85792790-85806683
Supporting publications (n)
2
EVMP confidence score
0.50
Fluorescence & Localization2
Tissue SpecificbrainCell SpecificAstrocytes
Function & Pathway6
Protein Function (2)
- Disease related genes
- Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
Cellular Component (2)
Biological Process (3)
Reactome (3)
Mediation Categories
Clinical-translation mediation
Relations & Evidence32
Ligand-Receptor Signaling (31)
31 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane_tmhmm | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Western blotting | 1 | 39996590 |
Sequence, Structure & Domains7
Sequences
Length
841
Mass
95,110
Sequence
MKLWIHLFYSSLLACISLHSQTPVLSSRGSCDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSRLKKESICPTPPVYEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAPGLIPYITKPSTQLPGPYCPIPCNCKVLSPSGLLIHCQERNIESLSDLRPPPQNPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLKTNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKKELKALNSEILCPGLVNNPSMPTQTSYLMVTTPATTTNTADTILRSLTDAVPLSVLILGLLIMFITIVFCAAGIVVLVLHRRRRYKKKQVDEQMRDNSPVHLQYSMYGHKTTHHTTERPSASLYEQHMVSPMVHVYRSPSFGPKHLEEEEERNEKEGSDAKHLQRSLLEQENHSPLTGSNMKYKTTNQSTEFLSFQDASSLYRNILEKERELQQLGITEYLRKNIAQLQPDMEAHYPGAHEELKLMETLMYSRPRKVLVEQTKNEYFELKANLHAEPDYLEVLEQQT
Domain & Motif Annotations
Repeat
89..110; LRR 1; 113..134; LRR 2; 137..158; LRR 3; 161..182; LRR 4; 184..205; LRR 5; 364..385; LRR 6; 388..409; LRR 7; 412..433; LRR 8; 436..457; LRR 9; 460..481; LRR 10; 483..504; LRR 11
Domain (FT)
27..67; LRRNT 1; 218..269; LRRCT 1; 320..361; LRRNT 2; 517..568; LRRCT 2
Protein Families
SLITRK family
Sequence Similarities
Belongs to the SLITRK family.
Clinical Relevance5
Disease Involvement
Deafness
Related Diseases (2)
Biomarker
Phase 1
Drugs
Supporting Publications2
| PMID | Title | Abstract |
|---|---|---|
| 38576002 | Therapy-induced senescent tumor cell-derived extracellular vesicles promote colorectal cancer progression through SERPINE1-mediated NF-κB p65 nuclear translocation. | No abstract available |
| 39535266 | Divergent Proteomic Profiles and Uptake Mechanisms of Exosomes Derived from Human Dental Pulp Stem Cells, Endothelial Cells, and Fibroblasts. | No abstract available |