Protein detail

TASP1

Threonine aspartase 1 (Taspase-1) (EC 3.4.25.-) [Cleaved into: Threonine aspartase subunit alpha; Threonine aspartase subunit beta]

Entry name TASP1	UniProt ID Q9H6P5	EVMP confidence score 0.38
Supporting publications (n) 2	Transmembrane count	Protein classification Disease related genesPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Threonine aspartase 1 (Taspase-1) (EC 3.4.25.-) [Cleaved into: Threonine aspartase subunit alpha; Threonine aspartase subunit beta]

Protein Class (2)

Disease related genesPredicted intracellular proteins

Protein Function (2)

Disease related genes
Predicted intracellular proteins

Ensembl

ENSG00000089123

Entrez Gene Symbol

TASP1

Gene Synonym (3)

C20orf13dJ585I14.2FLJ20212

Gene Description

Taspase 1

Chromosome

Position

13389392-13638932

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization2

Cell SpecificAstrocytes

Function & Pathway6

Protein Function (2)

Disease related genes
Predicted intracellular proteins

Cellular Component (2)

Molecular Function (2)

Biological Process (3)

Reactome (3)

Mediation Categories

Other mediation

Relations & Evidence8

Ligand-Receptor Signaling (6)

6 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
receptor	receptor	scConnect	No	Yes	No	No	No

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	TASP1	Q9H6P5	2	PDB	PDB:2a8lPDB:2a8jPDB:6vinPDB:6ugkPDB:2a8mPDB:2a8i

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry；RNA Sequencing；Flow cytometry	1	41307968

Sequence, Structure & Domains12

Sequences

Length

420

Mass

44,455

Sequence

MTMEKGMSSGEGLPSRSSQVSAGKITAKELETKQSYKEKRGGFVLVHAGAGYHSESKAKEYKHVCKRACQKAIEKLQAGALATDAVTAALVELEDSPFTNAGMGSNLNLLGEIECDASIMDGKSLNFGAVGALSGIKNPVSVANRLLCEGQKGKLSAGRIPPCFLVGEGAYRWAVDHGIPSCPPNIMTTRFSLAAFKRNKRKLELAERVDTDFMQLKKRRQSSEKENDSGTLDTVGAVVVDHEGNVAAAVSSGGLALKHPGRVGQAALYGCGCWAENTGAHNPYSTAVSTSGCGEHLVRTILARECSHALQAEDAHQALLETMQNKFISSPFLASEDGVLGGVIVLRSCRCSAEPDSSQNKQTLLVEFLWSHTTESMCVGYMSAQDGKAKTHISRLPPGAVAGQSVAIEGGVCRLESPVN

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9H6P5-1; Sequence=Displayed; Name=2; IsoId=Q9H6P5-2; Sequence=VSP_056327, VSP_056328; Name=3; IsoId=Q9H6P5-3; Sequence=VSP_056533, VSP_056534

Alternative Sequence

95..129; DSPFTNAGMGSNLNLLGEIECDASIMDGKSLNFGA -> VYTHSYTSWSCIQPSIHVLLVKRQRKSPLPRISTF (in isoform 2); 96..145; SPFTNAGMGSNLNLLGEIECDASIMDGKSLNFGAVGALSGIKNPVSVANR -> VESILCAPYWLENVHMLYKLRMLTKPCWRLCKTSLSVHLSLPVKMACLAE (in isoform 3); 130..420; Missing (in isoform 2); 146..420; Missing (in isoform 3)

3D Structural Models

Turn

122..124; 152..154; 221..225; 269..271; 326..329; 384..386; 402..404

Helix

57..77; 82..95; 139..151; 167..176; 184..187; 190..204; 265..267; 294..299; 302..309; 315..325; 331..333

Beta Strand

42..52; 99..102; 115..121; 127..133; 135..137; 157..160; 163..166; 235..241; 246..252; 272..276; 282..292; 341..348; 365..383; 390..395; 407..414

3D Structure

X-ray crystallography (9)

Domain & Motif Annotations

Region

1..23; Disordered

Protein Families

Ntn-hydrolase family

Sequence Similarities

Belongs to the Ntn-hydrolase family.

Clinical Relevance2

Disease Involvement

Disease variant

Antibody (2)

HPA030824 HPA030825

Supporting Publications2

PMID	Title	Abstract
34185707	Monocyte-released HERV-K dUTPase engages TLR4 and MCAM causing endothelial mesenchymal transition.	Here we show that monocytes overexpressing HERV-K dUTPase, as opposed to GFP, can release HERV-K dUTPase in extracellular vesicles (EVs) that cause pulmonary hypertension in mice in association with endothelial mesenchymal transition (EndMT) related to induction of SNAIL/SLUG and proinflammatory molecules IL-6 as well as VCAM1.
37438583	Exosomal PPARγ derived from macrophages suppresses LPS-induced peritonitis by negative regulation of CD14/TLR4 axis.	Using co-culture models and mouse peritonitis model, we showed that exosomes from Raw264.7 cells overexpressing PPARγ inhibited LPS-induced inflammation in co-cultured human PMCs and in mice through downregulating CD14 and TLR4, two key regulators of the salmonella infection pathway.