Protein detail
PG2IP
PGAP2-interacting protein (Cell wall biogenesis protein 43 C-terminal homolog)
Entry name PG2IP | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 10 | Protein classification Predicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information12
Protein Names
PGAP2-interacting protein (Cell wall biogenesis protein 43 C-terminal homolog)
Protein Class
Predicted membrane proteins
Transmembrane
13..33; Helical; 41..61; Helical; 93..113; Helical; 123..143; Helical; 196..216; Helical; 237..257; Helical; 273..293; Helical; 316..336; Helical; 349..369; Helical; 390..410; Helical
Transmembrane Count
10
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
CWH43-CFLJ21511PGAP2IP
Gene Description
Cell wall biogenesis 43 C-terminal homolog
Chromosome
4
Position
48986275-49062081
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization3
Tissue SpecificintestineCell SpecificB-cellsSingle-Nuclei Brain Specificleukocyte
Function & Pathway4
Cellular Component (3)
Biological Process (3)
Canonical Pathways (3)
- M7997 Sa caspase cascade
- M197 Pid hiv nef pathway
- M220 Pid caspase pathway
Mediation Categories (2)
Fusion and delivery mediationMetabolism mediation
Relations & Evidence9
Ligand-Receptor Signaling (8)
8 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry；Western blotting；RNA Sequencing；Immunofluorescence | 1 | 40689422 |
Sequence, Structure & Domains6
Sequences
Length
699
Mass
78,584
Sequence
MPSLWREILLESLLGCVSWSLYHDLGPMIYYFPLQTLELTGLEGFSIAFLSPIFLTITPFWKLVNKKWMLTLLRIITIGSIASFQAPNAKLRLMVLALGVSSSLIVQAVTWWSGSHLQRYLRIWGFILGQIVLVVLRIWYTSLNPIWSYQMSNKVILTLSAIATLDRIGTDGDCSKPEEKKTGEVATGMASRPNWLLAGAAFGSLVFLTHWVFGEVSLVSRWAVSGHPHPGPDPNPFGGAVLLCLASGLMLPSCLWFRGTGLIWWVTGTASAAGLLYLHTWAAAVSGCVFAIFTASMWPQTLGHLINSGTNPGKTMTIAMIFYLLEIFFCAWCTAFKFVPGGVYARERSDVLLGTMMLIIGLNMLFGPKKNLDLLLQTKNSSKVLFRKSEKYMKLFLWLLVGVGLLGLGLRHKAYERKLGKVAPTKEVSAAIWPFRFGYDNEGWSSLERSAHLLNETGADFITILESDASKPYMGNNDLTMWLGEKLGFYTDFGPSTRYHTWGIMALSRYPIVKSEHHLLPSPEGEIAPAITLTVNISGKLVDFVVTHFGNHEDDLDRKLQAIAVSKLLKSSSNQVIFLGYITSAPGSRDYLQLTEHGNVKDIDSTDHDRWCEYIMYRGLIRLGYARISHAELSDSEIQMAKFRIPDDPTNYRDNQKVVIDHREVSEKIHFNPRFGSYKEGHNYENNHHFHMNTPKYFL
Domain & Motif Annotations
Region
607..627; Required for function in lipid remodeling
Protein Families
PGAP2IP family
Sequence Similarities
Belongs to the PGAP2IP family.
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 27863537 | High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources. | No abstract available |