Protein detail

CH033

UPF0488 protein C8orf33

Entry name CH033	UniProt ID Q9H7E9	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

UPF0488 protein C8orf33

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000182307

Entrez Gene Symbol

C8orf33

Gene Synonym

FLJ20989

Gene Description

Chromosome 8 open reading frame 33

Chromosome

Position

145052465-145066685

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization5

Tissue Specificsalivary glandCell SpecificBreast lactating cellsSingle-Nuclei Brain Specificcommitted oligodendrocyte precursorBlood Cell SpecificgdT-cellBlood Lineage SpecificT-cells

Function & Pathway3

Protein Function

Predicted intracellular proteins

Molecular Function

GO:0005515 protein binding

Mediation Categories

Other mediation

Relations & Evidence6

Ligand-Receptor Signaling (2)

2 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (3)

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database
C8orf33 CTCF DKC1 GAR1 HP1BP3 KRR1 LARP7 LIN28B NOP10 POP1 RRP9 SRSF5 ZBTB11 ZC3H8 ZCCHC9 ZCRB1	O43818 O60832 O95625 P49711 Q13243 Q13601 Q4G0J3 Q5SSJ5 Q6ZN17 Q8N567 Q8N5P1 Q8TBF4 Q99575 Q9H7E9 Q9NPE3 Q9NY12	0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0	hu.MAP2
C8orf33 CTCF LARP7 ZBTB11 ZC3H8 ZCRB1	O95625 P49711 Q4G0J3 Q8N5P1 Q8TBF4 Q9H7E9	0:0:0:0:0:0	hu.MAP2
C8orf33 KRI1 LARP7 LIN28B ZC3H8 ZCRB1	Q4G0J3 Q6ZN17 Q8N5P1 Q8N9T8 Q8TBF4 Q9H7E9	0:0:0:0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	27605433

Sequence, Structure & Domains9

Sequences

Length

229

Mass

24,993

Sequence

MAALGHLAGEAAAAPGPGTPCASRGARLPGPVSSARNPSTVCLCPEQPTCSNADSRAHPLGDEGGTASKKQKNKKKTRNRASVANGGEKASEKLAPEEVPLSAEAQAQQLAQELAWCVEQLELGLKRQKPTPKQKEQAIGAIRTLRSKRTPLPRKRQLMHSLFGDYRAQMEAEWREALRALRAAAYSAQVQPVDGATRKKSQRVCRPRSIWRAKATLDMPDEEFRFNFF

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H7E9-1; Sequence=Displayed; Name=2; IsoId=Q9H7E9-2; Sequence=VSP_028169

Alternative Sequence

106; Q -> QARAGFGREGWNPR (in isoform 2)

Domain & Motif Annotations

Compositional Bias

1..16; Low complexity; 69..79; Basic residues

Region

1..96; Disordered

Protein Families

UPF0488 family

Sequence Similarities

Belongs to the UPF0488 family.

Clinical Relevance4

Antibody (2)

HPA024812 HPA026104

Interaction Protein (3)

ENSG00000108262ENSG00000114107ENSG00000173805

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications1

PMID	Title	Abstract
27605433	Secreted primary human malignant mesothelioma exosome signature reflects oncogenic cargo.	No abstract available