Protein detail

CNNM2

Metal transporter CNNM2 (Ancient conserved domain-containing protein 2) (Cyclin-M2)

Entry name CNNM2	UniProt ID Q9H8M5	EVMP confidence score 0.25
Supporting publications (n) 3	Transmembrane count 3	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Metal transporter CNNM2 (Ancient conserved domain-containing protein 2) (Cyclin-M2)

Protein Function (4)

Disease related genes
Transporters:Transporter channels and pores
Potential drug targets
Human disease related genes:Congenital disorders of metabolism:Other congenital disorders of metabolism

Transmembrane

251..271; Helical; 339..359; Helical; 369..389; Helical

Transmembrane Count

Ensembl

ENSG00000148842

Entrez Gene Symbol

CNNM2

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization2

Cell SpecificAstrocytes

Function & Pathway5

Protein Function (4)

Disease related genes
Transporters:Transporter channels and pores
Potential drug targets
Human disease related genes:Congenital disorders of metabolism:Other congenital disorders of metabolism

Cellular Component (3)

Molecular Function (2)

Biological Process (3)

Mediation Categories (2)

Fusion and delivery mediationMetabolism mediation

Relations & Evidence24

Ligand-Receptor Signaling (20)

20 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
peripheral	peripheral	UniProt_topology	No	No	No	Yes	No
peripheral	peripheral	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No

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Protein Complex Composition (3)

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
CNNM2 TPM3 TRAP1 UBC	P06753 P0CG48 Q12931 Q9H8M5	1:1:1:1	NetworkBlastCompleat	Compleat:HC7986
CNNM2	Q9H8M5	2	PDB	PDB:4iy2PDB:6n7ePDB:4iy4PDB:6dj3
ARL15 CNNM2	Q9H8M5 Q9NXU5	4:4	PDB	PDB:8f6d

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity CaptureMicrofluidics-Based Methods	Mass spectrometryWestern blottingFlow cytometryMORPHELISA	31	34889606 39290459 39949490 23376485 31508500 34071777 39873726 40545963 39940785 39443544 38871730 37702715 32795414 38731868 2353145 30071318 32927759 33580265 33729255 40619995 27312428 31018934 34867951 36635400 37686366 38164498 40098346 39001700 40669059 40091455 31588238

Sequence, Structure & Domains13

Sequences

Length

875

Mass

96,623

Sequence

MIGCGACEPKVKMAGGQAAAALPTWKMAARRSLSARGRGILQAAAGRLLPLLLLSCCCGAGGCAAVGENEETVIIGLRLEDTNDVSFMEGGALRVSERTRVKLRVYGQNINNETWSRIAFTEHERRRHSPGERGLGGPAPPEPDSGPQRCGIRTSDIIILPHIILNRRTSGIIEIEIKPLRKMEKSKSYYLCTSLSTPALGAGGSGSTGGAVGGKGGSGVAGLPPPPWAETTWIYHDGEDTKMIVGEEKKFLLPFWLQVIFISLLLCLSGMFSGLNLGLMALDPMELRIVQNCGTEKEKNYAKRIEPVRRQGNYLLCSLLLGNVLVNTTLTILLDDIAGSGLVAVVVSTIGIVIFGEIVPQAICSRHGLAVGANTIFLTKFFMMMTFPASYPVSKLLDCVLGQEIGTVYNREKLLEMLRVTDPYNDLVKEELNIIQGALELRTKTVEDVMTPLRDCFMITGEAILDFNTMSEIMESGYTRIPVFEGERSNIVDLLFVKDLAFVDPDDCTPLKTITKFYNHPLHFVFNDTKLDAMLEEFKKGKSHLAIVQRVNNEGEGDPFYEVLGIVTLEDVIEEIIKSEILDETDLYTDNRTKKKVAHRERKQDFSAFKQTDSEMKVKISPQLLLAMHRFLATEVEAFSPSQMSEKILLRLLKHPNVIQELKYDEKNKKAPEYYLYQRNKPVDYFVLILQGKVEVEAGKEGMKFEASAFSYYGVMALTASPVPLSLSRTFVVSRTELLAAGSPGENKSPPRPCGLNHSDSLSRSDRIDAVTPTLGSSNNQLNSSLLQVYIPDYSVRALSDLQFVKISRQQYQNALMASRMDKTPQSSDSENTKIELTLTELHDGLPDETANLLNEQNCVTHSKANHSLHNEGAI

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9H8M5-1; Sequence=Displayed; Name=2; IsoId=Q9H8M5-2; Sequence=VSP_027080; Name=3; IsoId=Q9H8M5-3; Sequence=VSP_027077, VSP_027078

Alternative Sequence

541..552; GKSHLAIVQRVN -> EHTNKKPKSYQH (in isoform 3); 553..875; Missing (in isoform 3); 721..742; Missing (in isoform 2)

3D Structural Models

Turn

580..582; 641..643; 656..658; 667..670; 699..702; 775..777

Helix

430..443; 446..449; 453..455; 467..476; 497..500; 505..507; 511..518; 531..539; 569..579; 622..635; 637..639; 646..654; 672..674; 716..719; 809..819

Beta Strand

450..452; 459..462; 479..487; 491..496; 524..526; 540..542; 544..552; 554..558; 560..568; 590..592; 659..662; 675..677; 685..692; 694..698; 703..707; 793..800; 802..808

3D Structure

X-ray crystallography (7)

Domain & Motif Annotations

Domain (FT)

251..431; CNNM transmembrane; 450..511; CBS 1; 518..584; CBS 2

Region

121..151; Disordered; 742..763; Disordered

Protein Families

ACDP family

Sequence Similarities

Belongs to the ACDP family.

Clinical Relevance1

Drugs

MERCAPTOPURINE

Supporting Publications3

PMID	Title	Abstract
36064647	Systemic proteomics and miRNA profile analysis of exosomes derived from human pluripotent stem cells.	No abstract available
38113368	In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.	No abstract available
41068253	Identification of plasma extracellular vesicle protein biomarkers in diabetic retinopathy progression.	No abstract available