Protein detail
CNNM2
Metal transporter CNNM2 (Ancient conserved domain-containing protein 2) (Cyclin-M2)
Protein symbol CNNM2 | UniProt ID | EVMP score 0.25 |
Frequency 3 | Transmembrane count 3 | Protein classification |
Basic Information
Protein Names
Metal transporter CNNM2 (Ancient conserved domain-containing protein 2) (Cyclin-M2)
Protein Function
- Disease related genes
- Transporters:Transporter channels and pores
- Potential drug targets
- Human disease related genes:Congenital disorders of metabolism:Other congenital disorders of metabolism
Transmembrane
251..271; Helical; 339..359; Helical; 369..389; Helical
Transmembrane Count
3
Ensembl
Entrez Gene Symbol
Frequency
3
EVMP Score
0.25
Fluorescence & Localization
Cell SpecificAstrocytes
Function & Pathway
Protein Function
- Disease related genes
- Transporters:Transporter channels and pores
- Potential drug targets
- Human disease related genes:Congenital disorders of metabolism:Other congenital disorders of metabolism
Cellular Component
Biological Process
Mediation Categories
Fusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
20 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| peripheral | peripheral | UniProt_topology | No | No | No | Yes | No |
| peripheral | peripheral | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity CaptureMicrofluidics-Based Methods | Mass spectrometryWestern blottingFlow cytometryMORPHELISA | 31 | 3488960639290459399494902337648531508500340717773987372640545963399407853944354438871730377027153279541438731868235314530071318329277593358026533729255406199952731242831018934348679513663540037686366381644984009834639001700406690594009145531588238 |
Sequence, Structure & Domains
Sequences
Length
875
Mass
96,623
Sequence
MIGCGACEPKVKMAGGQAAAALPTWKMAARRSLSARGRGILQAAAGRLLPLLLLSCCCGAGGCAAVGENEETVIIGLRLEDTNDVSFMEGGALRVSERTRVKLRVYGQNINNETWSRIAFTEHERRRHSPGERGLGGPAPPEPDSGPQRCGIRTSDIIILPHIILNRRTSGIIEIEIKPLRKMEKSKSYYLCTSLSTPALGAGGSGSTGGAVGGKGGSGVAGLPPPPWAETTWIYHDGEDTKMIVGEEKKFLLPFWLQVIFISLLLCLSGMFSGLNLGLMALDPMELRIVQNCGTEKEKNYAKRIEPVRRQGNYLLCSLLLGNVLVNTTLTILLDDIAGSGLVAVVVSTIGIVIFGEIVPQAICSRHGLAVGANTIFLTKFFMMMTFPASYPVSKLLDCVLGQEIGTVYNREKLLEMLRVTDPYNDLVKEELNIIQGALELRTKTVEDVMTPLRDCFMITGEAILDFNTMSEIMESGYTRIPVFEGERSNIVDLLFVKDLAFVDPDDCTPLKTITKFYNHPLHFVFNDTKLDAMLEEFKKGKSHLAIVQRVNNEGEGDPFYEVLGIVTLEDVIEEIIKSEILDETDLYTDNRTKKKVAHRERKQDFSAFKQTDSEMKVKISPQLLLAMHRFLATEVEAFSPSQMSEKILLRLLKHPNVIQELKYDEKNKKAPEYYLYQRNKPVDYFVLILQGKVEVEAGKEGMKFEASAFSYYGVMALTASPVPLSLSRTFVVSRTELLAAGSPGENKSPPRPCGLNHSDSLSRSDRIDAVTPTLGSSNNQLNSSLLQVYIPDYSVRALSDLQFVKISRQQYQNALMASRMDKTPQSSDSENTKIELTLTELHDGLPDETANLLNEQNCVTHSKANHSLHNEGAI
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9H8M5-1; Sequence=Displayed; Name=2; IsoId=Q9H8M5-2; Sequence=VSP_027080; Name=3; IsoId=Q9H8M5-3; Sequence=VSP_027077, VSP_027078
Alternative Sequence
541..552; GKSHLAIVQRVN -> EHTNKKPKSYQH (in isoform 3); 553..875; Missing (in isoform 3); 721..742; Missing (in isoform 2)
3D Structural Models
Turn
580..582; 641..643; 656..658; 667..670; 699..702; 775..777
Helix
430..443; 446..449; 453..455; 467..476; 497..500; 505..507; 511..518; 531..539; 569..579; 622..635; 637..639; 646..654; 672..674; 716..719; 809..819
Beta Strand
450..452; 459..462; 479..487; 491..496; 524..526; 540..542; 544..552; 554..558; 560..568; 590..592; 659..662; 675..677; 685..692; 694..698; 703..707; 793..800; 802..808
3D Structure
X-ray crystallography (7)
Domain & Motif Annotations
Domain (FT)
251..431; CNNM transmembrane; 450..511; CBS 1; 518..584; CBS 2
Region
121..151; Disordered; 742..763; Disordered
Protein Families
ACDP family
Sequence Similarities
Belongs to the ACDP family.
Clinical Relevance
Drugs