Protein detail
SR5A3
Polyprenal reductase (EC 1.3.1.94) (3-oxo-5-alpha-steroid 4-dehydrogenase 3) (EC 1.3.1.22) (Steroid 5-alpha-reductase 2-like) (Steroid 5-alpha-reductase 3) (S5AR 3) (SR type 3)
Entry name SR5A3 | UniProt ID | EVMP confidence score 0.28 |
Supporting publications (n) 1 | Transmembrane count 6 | Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Polyprenal reductase (EC 1.3.1.94) (3-oxo-5-alpha-steroid 4-dehydrogenase 3) (EC 1.3.1.22) (Steroid 5-alpha-reductase 2-like) (Steroid 5-alpha-reductase 3) (S5AR 3) (SR type 3)
Protein Class (6)
Disease related genesEnzymesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteins
Protein Function (5)
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of glycan/glycoprotein metabolism
- ENZYME proteins:Oxidoreductases
- Potential drug targets
- Enzymes
- Disease related genes
Transmembrane
12..34; Helical; 81..101; Helical; 118..138; Helical; 158..178; Helical; 195..215; Helical; 261..281; Helical
Transmembrane Count
6
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
FLJ13352SRD5A2LSRD5A2L1
Gene Description
Steroid 5 alpha-reductase 3
Chromosome
4
Position
55346213-55373100
Supporting publications (n)
1
EVMP confidence score
0.28
Fluorescence & Localization
Cell SpecificAstrocytesSecretome LocationIntracellular and membraneSecretome FunctionCell adhesion
Function & Pathway
Protein Function (5)
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of glycan/glycoprotein metabolism
- ENZYME proteins:Oxidoreductases
- Potential drug targets
- Enzymes
- Disease related genes
Cellular Component (2)
Molecular Function (4)
Biological Process (3)
KEGG (3)
Reactome (12)
- R-hsa-193048 androgen biosynthesis
- R-hsa-446203 asparagine n linked glycosylation
- R-hsa-446193 biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein
- R-hsa-5609975 diseases associated with glycosylation precursor biosynthesis
- R-hsa-3781865 diseases of glycosylation
- R-hsa-5668914 diseases of metabolism
- R-hsa-556833 metabolism of lipids
- R-hsa-8957322 metabolism of steroids
- R-hsa-196071 metabolism of steroid hormones
- R-hsa-597592 post translational protein modification
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Mediation Categories (2)
Clinical-translation mediationMetabolism mediation
Relations & Evidence12
Ligand-Receptor Signaling (10)
10 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| transmembrane | transmembrane | UniProt_location | |||||
| transmembrane | transmembrane | UniProt_topology | |||||
| transmembrane | transmembrane | UniProt_keyword | |||||
| transmembrane | transmembrane | Ramilowski_location | |||||
| transmembrane | transmembrane | OmniPath | |||||
| transmembrane | transmembrane_predicted | Phobius |
Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Western blotting | 1 | 39996590 |
Sequence, Structure & Domains
Sequences
Length
318
Mass
36,521
Sequence
MAPWAEAEHSALNPLRAVWLTLTAAFLLTLLLQLLPPGLLPGCAIFQDLIRYGKTKCGEPSRPAACRAFDVPKRYFSHFYIISVLWNGFLLWCLTQSLFLGAPFPSWLHGLLRILGAAQFQGGELALSAFLVLVFLWLHSLRRLFECLYVSVFSNVMIHVVQYCFGLVYYVLVGLTVLSQVPMDGRNAYITGKNLLMQARWFHILGMMMFIWSSAHQYKCHVILGNLRKNKAGVVIHCNHRIPFGDWFEYVSSPNYLAELMIYVSMAVTFGFHNLTWWLVVTNVFFNQALSAFLSHQFYKSKFVSYPKHRKAFLPFLF
Domain & Motif Annotations
Protein Families (2)
- Steroid 5-alpha reductase family
- Polyprenal reductase subfamily
Sequence Similarities
Belongs to the steroid 5-alpha reductase family. Polyprenal reductase subfamily.
Clinical Relevance
Disease Involvement (4)
CataractCongenital disorder of glycosylationDisease variantIntellectual disability
Related Diseases (3)
Drugs (2)
Antibody
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 41167904 | Accessing the proteome of extracellular vesicles via rapid acoustic isolation of a minute human blood plasma sample. | No related sentences available |