Protein detail

AKTIP

AKT-interacting protein (Ft1) (Fused toes protein homolog)

Entry name AKTIP	UniProt ID Q9H8T0	EVMP confidence score 0.38
Supporting publications (n) 4	Transmembrane count	Protein classification Plasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

AKT-interacting protein (Ft1) (Fused toes protein homolog)

Protein Class (2)

Plasma proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000166971

Entrez Gene Symbol

AKTIP

Gene Synonym (2)

FLJ13258FTS

Gene Description

AKT interacting protein

Chromosome

Position

53491040-53504411

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization3

Tissue SpecificbrainCell SpecificAstrocytes

Function & Pathway5

Protein Function

Predicted intracellular proteins

Cellular Component (5)

Molecular Function (2)

Biological Process (3)

Mediation Categories

Fusion and delivery mediation

Relations & Evidence24

Ligand-Receptor Signaling (7)

7 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Protein Complex Composition (16)

16 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
FHF complex	AKTIP FHIP1B HOOK1 HOOK2 HOOK3	Q86VS8 Q8N612 Q96ED9 Q9H8T0 Q9UJC3	1:1:1:1:1	CORUMCompleatComplexPortal	Compleat:HC1477CORUM:6109	32073997 34882091 14755292 18799622
FTS-Hook-FHIP cargo adaptor complexFHIP1A-HOOK1/3 variant	AKTIP FHIP1A HOOK1 HOOK3	Q05DH4 Q86VS8 Q9H8T0 Q9UJC3	1:1:1:1	ComplexPortal		32073997 34882091 14755292
FTS-Hook-FHIP cargo adaptor complexFHIP1B-HOOK1/3 variant	AKTIP FHIP1B HOOK1 HOOK3	Q86VS8 Q8N612 Q9H8T0 Q9UJC3	1:1:1:1	ComplexPortal		32073997 34882091 14755292
FTS-Hook-FHIP cargo adaptor complexFHIP2A-HOOK2 variant	AKTIP FHIP2A HOOK2	Q5W0V3 Q96ED9 Q9H8T0	1:1:1	ComplexPortal		32073997 34882091 14755292
FTS-Vps16 complex	AKTIP VPS16	Q9H269 Q9H8T0	0:0	CORUM	CORUM:6124	18799622
FTS-Vps18 complex	AKTIP VPS18	Q9H8T0 Q9P253	0:0	CORUM	CORUM:6125	18799622
FTS-Vps41 complex	AKTIP VPS41	P49754 Q9H8T0	0:0	CORUM	CORUM:6126	18799622
HOPS complex	AKTIP HOOK1 HOOK2 HOOK3 VIPAS39 VPS11 VPS16 VPS18 VPS33A VPS33B VPS39 VPS41	P49754 Q86VS8 Q96AX1 Q96ED9 Q96JC1 Q9H267 Q9H269 Q9H270 Q9H8T0 Q9H9C1 Q9P253 Q9UJC3	1:1:1:1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC1865	18799622 19109425
HT_DM_Cluster264	AKTIP HOOK1 HOOK2 HOOK3	Q86VS8 Q96ED9 Q9H8T0 Q9UJC3	1:1:1:1	Compleat	Compleat:HC1285	22036573
	AKTIP CHCHD3 MTX1 MTX2 POLA2 SAMM50	O75431 Q13505 Q14181 Q9H8T0 Q9NX63 Q9Y512	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6724

Page 1 of 2Next

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	5	38225453 38731868 30071318 33580265 37686366

Sequence, Structure & Domains14

Sequences

Length

292

Mass

33,128

Sequence

MNPFWSMSTSSVRKRSEGEEKTLTGDVKTSPPRTAPKKQLPSIPKNALPITKPTSPAPAAQSTNGTHASYGPFYLEYSLLAEFTLVVKQKLPGVYVQPSYRSALMWFGVIFIRHGLYQDGVFKFTVYIPDNYPDGDCPRLVFDIPVFHPLVDPTSGELDVKRAFAKWRRNHNHIWQVLMYARRVFYKIDTASPLNPEAAVLYEKDIQLFKSKVVDSVKVCTARLFDQPKIEDPYAISFSPWNPSVHDEAREKMLTQKKPEEQHNKSVHVAGLSWVKPGSVQPFSKEEKTVAT

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H8T0-1; Sequence=Displayed; Name=2; IsoId=Q9H8T0-2; Sequence=VSP_037631

Alternative Sequence

256; Q -> QK (in isoform 2)

3D Structural Models

Turn

67..69; 116..119; 130..133; 153..155; 169..171; 184..186; 223..225

Helix

71..88; 160..162; 174..183; 196..202; 206..222; 243..254

Beta Strand

94..98; 103..112; 120..127; 139..144

3D Structure

Electron microscopy (1)

Domain & Motif Annotations

Compositional Bias

1..11; Polar residues; 14..23; Basic and acidic residues

Domain (FT)

74..222; UBC core

Region

1..63; Disordered

Protein Families (2)

Ubiquitin-conjugating enzyme family
FTS subfamily

Sequence Similarities

Belongs to the ubiquitin-conjugating enzyme family. FTS subfamily.

Clinical Relevance4

Antibody (2)

HPA041794 HPA046300

Interaction Protein (5)

ENSG00000095066ENSG00000119401ENSG00000134709ENSG00000164142ENSG00000168172

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications4

PMID	Title	Abstract
26775013	Proteomic characterization of circulating extracellular vesicles identifies novel serum myeloma associated markers.	No abstract available
32795414	Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers.	Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers.
40545963	Extracellular Vesicle Proteome Analysis Improves Diagnosis of Recurrence in Triple-Negative Breast Cancer.	No abstract available
40784529	Serum-derived exosome proteomics unveils the distinct and adjustable nature of the dampness constitution in traditional Chinese medicine.	No abstract available