Protein detail

PPIP2

Proline-serine-threonine phosphatase-interacting protein 2 (PEST phosphatase-interacting protein 2)

Entry name PPIP2	UniProt ID Q9H939	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information10

Protein Names

Proline-serine-threonine phosphatase-interacting protein 2 (PEST phosphatase-interacting protein 2)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000152229

Entrez Gene Symbol

PSTPIP2

Gene Description

Proline-serine-threonine phosphatase interacting protein 2

Chromosome

Position

45983536-46072272

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization2

Tissue SpecificbrainCell SpecificAstrocytes

Function & Pathway5

Protein Function

Predicted intracellular proteins

Cellular Component (4)

Molecular Function

GO:0051015 actin filament binding

Biological Process (3)

Mediation Categories

Fusion and delivery mediation

Relations & Evidence7

Ligand-Receptor Signaling (6)

6 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
fbar_actin_dynamics_endocytosis	intracellular_intercellular_related	HGNC	Yes	No	No	No	No
intracellular_intercellular_related	intracellular_intercellular_related	OmniPath	Yes	No	No	No	No

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	5	28986585 27894104 30646616 38321535 33709510

Sequence, Structure & Domains8

Sequences

Length

334

Mass

38,858

Sequence

MTRSLFKGNFWSADILSTIGYDNIIQHLNNGRKNCKEFEDFLKERAAIEERYGKDLLNLSRKKPCGQSEINTLKRALEVFKQQVDNVAQCHIQLAQSLREEARKMEEFREKQKLQRKKTELIMDAIHKQKSLQFKKTMDAKKNYEQKCRDKDEAEQAVSRSANLVNPKQQEKLFVKLATSKTAVEDSDKAYMLHIGTLDKVREEWQSEHIKACEAFEAQECERINFFRNALWLHVNQLSQQCVTSDEMYEQVRKSLEMCSIQRDIEYFVNQRKTGQIPPAPIMYENFYSSQKNAVPAGKATGPNLARRGPLPIPKSSPDDPNYSLVDDYSLLYQ

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H939-1; Sequence=Displayed; Name=2; IsoId=Q9H939-2; Sequence=VSP_004070

Alternative Sequence

248..334; MYEQVRKSLEMCSIQRDIEYFVNQRKTGQIPPAPIMYENFYSSQKNAVPAGKATGPNLARRGPLPIPKSSPDDPNYSLVDDYSLLYQ -> HPSCMRISTPPRRMQSQQERLQGLTWQGEDPSQFLKAHQMIPITLWLMTTVCSISKINETRAFSG (in isoform 2)

Domain & Motif Annotations

Coiled Coil

66..166

Domain (FT)

4..264; F-BAR

Region

295..322; Disordered

Clinical Relevance1

Antibody

HPA040944

Supporting Publications1

PMID	Title	Abstract
37886648	Pathological mechanisms of type 1 diabetes in children: investigation of the exosomal protein expression profile.	No abstract available