Protein detail

PPIP2

Proline-serine-threonine phosphatase-interacting protein 2 (PEST phosphatase-interacting protein 2)

Entry name PPIP2	UniProt ID Q9H939	EVMP score 0.50
Frequency 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Proline-serine-threonine phosphatase-interacting protein 2 (PEST phosphatase-interacting protein 2)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000152229

Entrez Gene Symbol

PSTPIP2

Gene Description

Proline-serine-threonine phosphatase interacting protein 2

Chromosome

Position

45983536-46072272

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue SpecificbrainCell SpecificAstrocytes

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

Molecular Function

GO:0051015 actin filament binding

Biological Process

Mediation Categories

Fusion and delivery mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

6 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
fbar_actin_dynamics_endocytosis	intracellular_intercellular_related	HGNC	Yes	No	No	No	No
intracellular_intercellular_related	intracellular_intercellular_related	OmniPath	Yes	No	No	No	No

Regulatory Interaction Network

0 records.

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	5	28986585 27894104 30646616 38321535 33709510

Sequence, Structure & Domains

Sequences

Length

334

Mass

38,858

Sequence

MTRSLFKGNFWSADILSTIGYDNIIQHLNNGRKNCKEFEDFLKERAAIEERYGKDLLNLSRKKPCGQSEINTLKRALEVFKQQVDNVAQCHIQLAQSLREEARKMEEFREKQKLQRKKTELIMDAIHKQKSLQFKKTMDAKKNYEQKCRDKDEAEQAVSRSANLVNPKQQEKLFVKLATSKTAVEDSDKAYMLHIGTLDKVREEWQSEHIKACEAFEAQECERINFFRNALWLHVNQLSQQCVTSDEMYEQVRKSLEMCSIQRDIEYFVNQRKTGQIPPAPIMYENFYSSQKNAVPAGKATGPNLARRGPLPIPKSSPDDPNYSLVDDYSLLYQ

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H939-1; Sequence=Displayed; Name=2; IsoId=Q9H939-2; Sequence=VSP_004070

Alternative Sequence

248..334; MYEQVRKSLEMCSIQRDIEYFVNQRKTGQIPPAPIMYENFYSSQKNAVPAGKATGPNLARRGPLPIPKSSPDDPNYSLVDDYSLLYQ -> HPSCMRISTPPRRMQSQQERLQGLTWQGEDPSQFLKAHQMIPITLWLMTTVCSISKINETRAFSG (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Coiled Coil

66..166

Domain (FT)

4..264; F-BAR

Region

295..322; Disordered

Clinical Relevance

Antibody

HPA040944