Protein detail

MARH7

E3 ubiquitin-protein ligase MARCHF7 (EC 2.3.2.27) (Axotrophin) (Membrane-associated RING finger protein 7) (Membrane-associated RING-CH protein VII) (MARCH-VII) (RING finger protein 177) (RING-type E3 ubiquitin transferase MARCHF7)

Entry name
MARH7
UniProt ID
Q9H992
EVMP confidence score
0.40
Supporting publications (n)
2
Transmembrane count
Protein classification
EnzymesMetabolic proteinsPredicted intracellular proteins
Basic Information
Protein Names
E3 ubiquitin-protein ligase MARCHF7 (EC 2.3.2.27) (Axotrophin) (Membrane-associated RING finger protein 7) (Membrane-associated RING-CH protein VII) (MARCH-VII) (RING finger protein 177) (RING-type E3 ubiquitin transferase MARCHF7)
Protein Class (3)
EnzymesMetabolic proteinsPredicted intracellular proteins
Protein Function (3)
  • ENZYME proteins:Transferases
  • Enzymes
  • Predicted intracellular proteins
Ensembl
ENSG00000136536
Entrez Gene Symbol
MARCHF7
Gene Synonym (4)
AXOTMARCH-VIIMARCH7RNF177
Gene Description
Membrane associated ring-CH-type finger 7
Chromosome
2
Position
159712457-159771027
Supporting publications (n)
2
EVMP confidence score
0.40
Fluorescence & Localization
Tissue SpecificbrainCell SpecificBergmann glia
Function & Pathway
Protein Function (3)
  • ENZYME proteins:Transferases
  • Enzymes
  • Predicted intracellular proteins
Cellular Component (4)
Molecular Function (6)
Biological Process (3)
Mediation Categories (2)
Adhesion and uptake mediationImmune mediation
Relations & Evidence147

Ligand-Receptor Signaling (4)

4 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularComPPI
intracellularintracellularGO_Intercell
intracellularintracellularUniProt_location
intracellularintracellularOmniPath

Regulatory Interaction Network (138)

138 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
COMPLEX:P62256_P62987MARH7Q9H992YesYesSIGNORSIGNOR:34199813
COMPLEX:P51668_P62987MARH7Q9H992YesYesSIGNORSIGNOR:34199813
COMPLEX:P62987_P63279MARH7Q9H992YesYesSIGNORSIGNOR:34199813
COMPLEX:P62987_Q5VVX9MARH7Q9H992YesYesSIGNORSIGNOR:34199813
COMPLEX:P0CG47_Q13404MARH7Q9H992YesYesSIGNORSIGNOR:34199813
COMPLEX:O00762_P62979MARH7Q9H992YesYesSIGNORSIGNOR:34199813
COMPLEX:P62987_Q15819MARH7Q9H992YesYesSIGNORSIGNOR:34199813
COMPLEX:P62987_P68036MARH7Q9H992YesYesSIGNORSIGNOR:34199813
COMPLEX:P62979_Q9Y2X8MARH7Q9H992YesYesSIGNORSIGNOR:34199813
COMPLEX:P61077_P62987MARH7Q9H992YesYesSIGNORSIGNOR:34199813
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Protein Complex Composition (4)

4 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
Ub:RING_E3MARCHF7UBBP0CG47Q9H9920:0SIGNORSIGNOR:SIGNOR-C519
Ub:RING_E3MARCHF7UBCP0CG48Q9H9920:0SIGNORSIGNOR:SIGNOR-C519
Ub:RING_E3MARCHF7RPS27AP62979Q9H9920:0SIGNORSIGNOR:SIGNOR-C519
Ub:RING_E3MARCHF7UBA52P62987Q9H9920:0SIGNORSIGNOR:SIGNOR-C519

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyMass spectrometry [LTQ-FT Ultra]Mass spectrometry137250483
Sequence, Structure & Domains

Sequences

Length
704
Mass
78,051
Sequence
MESKPSRIPRRISVQPSSSLSARMMSGSRGSSLNDTYHSRDSSFRLDSEYQSTSASASASPFQSAWYSESEITQGARSRSQNQQRDHDSKRPKLSCTNCTTSAGRNVGNGLNTLSDSSWRHSQVPRSSSMVLGSFGTDLMRERRDLERRTDSSISNLMDYSHRSGDFTTSSYVQDRVPSYSQGARPKENSMSTLQLNTSSTNHQLPSEHQTILSSRDSRNSLRSNFSSRESESSRSNTQPGFSYSSSRDEAPIISNSERVVSSQRPFQESSDNEGRRTTRRLLSRIASSMSSTFFSRRSSQDSLNTRSLNSENSYVSPRILTASQSRSNVPSASEVPDNRASEASQGFRFLRRRWGLSSLSHNHSSESDSENFNQESEGRNTGPWLSSSLRNRCTPLFSRRRREGRDESSRIPTSDTSSRSHIFRRESNEVVHLEAQNDPLGAAANRPQASAASSSATTGGSTSDSAQGGRNTGISGILPGSLFRFAVPPALGSNLTDNVMITVDIIPSGWNSADGKSDKTKSAPSRDPERLQKIKESLLLEDSEEEEGDLCRICQMAAASSSNLLIEPCKCTGSLQYVHQDCMKKWLQAKINSGSSLEAVTTCELCKEKLELNLEDFDIHELHRAHANEQAEYEFISSGLYLVVLLHLCEQSFSDMMGNTNEPSTRVRFINLARTLQAHMEDLETSEDDSEEDGDHNRTFDIA
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H992-1; Sequence=Displayed; Name=2; IsoId=Q9H992-2; Sequence=VSP_054406
Alternative Sequence
1..51; MESKPSRIPRRISVQPSSSLSARMMSGSRGSSLNDTYHSRDSSFRLDSEYQ -> MIGNYDHLMSLVT (in isoform 2)

Domain & Motif Annotations

Compositional Bias
17..33; Low complexity; 37..48; Basic and acidic residues; 52..65; Low complexity; 66..83; Polar residues; 95..126; Polar residues; 189..212; Polar residues; 237..246; Polar residues; 254..270; Polar residues; 294..303; Low complexity; 304..313; Polar residues; 319..332; Polar residues; 412..421; Polar residues; 444..470; Low complexity; 684..695; Acidic residues
Zinc Finger
544..614; RING-CH-type
Domain (CC)
The RING-CH-type zinc finger domain is required for E3 ligase activity.
Region
1..126; Disordered; 157..279; Disordered; 294..313; Disordered; 319..343; Disordered; 361..425; Disordered; 444..473; Disordered; 683..704; Disordered
Clinical Relevance
Antibody (2)
HPA014275HPA022152
Interaction Protein (3)
ENSG00000078140ENSG00000101367ENSG00000163513
Interaction Count
3
Interaction Dataset (3)
intact_biogridintact_biogrid_opencellbiogrid_bioplex
Supporting Publications2
PMIDTitleRelated sentences
30865381Surfaceome of Exosomes Secreted from the Colorectal Cancer Cell Line SW480: Peripheral and Integral Membrane Proteins Analyzed by Proteolysis and TX114.No related sentences available
32384937Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles.No related sentences available