Protein detail

ANRA2

Ankyrin repeat family A protein 2 (RFXANK-like protein 2)

Entry name ANRA2	UniProt ID Q9H9E1	EVMP confidence score 0.50
Supporting publications (n) 2	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information10

Protein Names

Ankyrin repeat family A protein 2 (RFXANK-like protein 2)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000164331

Entrez Gene Symbol

ANKRA2

Gene Description

Ankyrin repeat family A member 2

Chromosome

Position

73552190-73565667

Supporting publications (n)

EVMP confidence score

0.50

Function & Pathway5

Protein Function

Predicted intracellular proteins

Cellular Component (6)

Molecular Function (5)

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence9

Ligand-Receptor Signaling (5)

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (3)

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
ANKRA2 RFX5 RFX7 RFXANK RFXAP	O00287 O14593 P48382 Q2KHR2 Q9H9E1	0:0:0:0:0	hu.MAP2
ANKRA2 HDAC4	P56524 Q9H9E1	1:1	PDB	PDB:3v31
ANKRA2 RFX7	Q2KHR2 Q9H9E1	1:1	PDB	PDB:4qqi

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry；RNA Sequencing；Flow cytometry	1	41307968

Sequence, Structure & Domains7

Sequences

Length

313

Mass

34,272

Sequence

MDTSTNLDIGAQLIVEECPSTYSLTGMPDIKIEHPLDPNSEEGSAQGVAMGMKFILPNRFDMNVCSRFVKSLNEEDSKNIQDQVNSDLEVASVLFKAECNIHTSPSPGIQVRHVYTPSTTKHFSPIKQSTTLTNKHRGNEVSTTPLLANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVIESHLLKLLQNIKE

3D Structural Models

Helix

144..147; 148..150; 153..158; 162..171; 185..191; 195..203; 218..225; 228..237; 251..257; 261..269; 284..291; 294..307

3D Structure

Electron microscopy (3); X-ray crystallography (6)

Domain & Motif Annotations

Repeat

148..180; ANK 1; 181..213; ANK 2; 214..246; ANK 3; 247..279; ANK 4; 280..313; ANK 5

Domain (CC)

The ankyrin repeats, mainly ANK 2, ANK 3 and ANK 4, mediate interaction with a wide array of PxLPxI/L motif-containing proteins including HDAC4 and LRP2. The PxLPxI/L motif of interactors can contain a Ser or a Thr residue in position 2, which phosphorylation prevents the interaction with ANKRA2..

Clinical Relevance4

Antibody (2)

HPA003968 HPA065263

Interaction Protein (4)

ENSG00000068024ENSG00000108840ENSG00000169515ENSG00000181827

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications2

PMID	Title	Abstract
37922300	Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women.	No abstract available
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available