Protein detail

KANL2

KAT8 regulatory NSL complex subunit 2 (NSL complex protein NSL2) (Non-specific lethal 2 homolog)

Entry name KANL2	UniProt ID Q9H9L4	EVMP confidence score 0.38
Supporting publications (n) 2	Transmembrane count	Protein classification Essential proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

KAT8 regulatory NSL complex subunit 2 (NSL complex protein NSL2) (Non-specific lethal 2 homolog)

Protein Class (2)

Essential proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000139620

Entrez Gene Symbol

KANSL2

Gene Synonym (3)

C12orf41FLJ20436NSL2

Gene Description

KAT8 regulatory NSL complex subunit 2

Chromosome

Position

48653211-48682238

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization5

Tissue SpecificbrainCell SpecificBergmann gliaSingle-Nuclei Brain SpecificBergmann gliaSecretome LocationSecreted - unknown locationSecretome FunctionCell adhesion

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (7)

Molecular Function

GO:0005515 protein binding

Biological Process (3)

Reactome (5)

Mediation Categories

Other mediation

Relations & Evidence11

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (6)

6 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
NSL	HCFC1 KANSL2 KANSL3 KAT8 MCRS1 NSL1 PHF20 WDR5	P51610 P61964 Q96EZ8 Q96IY1 Q9BVI0 Q9H7Z6 Q9H9L4 Q9P2N6	1:1:1:1:1:1:1:1	Compleat	Compleat:HC2262	20018852
NSL histone acetyltransferase	HCFC1 KANSL1 KANSL2 KANSL3 KAT8 MCRS1 OGT PHF20 WDR5	O15294 P51610 P61964 Q7Z3B3 Q96EZ8 Q9BVI0 Q9H7Z6 Q9H9L4 Q9P2N6	1:1:1:1:1:1:1:1:1	CORUMSIGNORComplexPortal	PDB:4cy1intact:EBI-12555779SIGNOR:SIGNOR-C413CORUM:7221PDB:4cy2	25971333 24244196 14755292 24788516 20018852
histone acetyltransferase complex	CREBBP EP300 HCFC1 ING4 JADE1 JADE2 JADE3 KANSL1 KANSL2 KANSL3 KAT7 KAT8 MCRS1 OGT PHF20 WDR5	O15294 O95251 P51610 P61964 Q09472 Q6IE81 Q7Z3B3 Q92613 Q92793 Q96EZ8 Q9BVI0 Q9H7Z6 Q9H9L4 Q9NQC1 Q9P2N6 Q9UNL4	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC588	16387653
	KANSL1 KANSL2 WDR5	P61964 Q7Z3B3 Q9H9L4	1:1:1	PDB	PDB:4cy2
	DUS2 KANSL1 KANSL2 KANSL3 KAT8 MCRS1 PHF20	Q7Z3B3 Q96EZ8 Q9BVI0 Q9H7Z6 Q9H9L4 Q9NX74 Q9P2N6	0:0:0:0:0:0:0	hu.MAP2
	DUS2 KANSL1 KANSL2 MCRS1 PHF20	Q7Z3B3 Q96EZ8 Q9BVI0 Q9H9L4 Q9NX74	0:0:0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry；RNA Sequencing；Flow cytometry	1	41307968

Sequence, Structure & Domains8

Sequences

Length

492

Mass

55,042

Sequence

MNRIRIHVLPTNRGRITPVPRSQEPLSCAFTHRPCSHPRLEGQEFCIKHILEDKNAPFKQCSYISTKNGKRCPNAAPKPEKKDGVSFCAEHVRRNALALHAQMKKTNPGPVGETLLCQLSSYAKTELGSQTPESSRSEASRILDEDSWSDGEQEPITVDQTWRGDPDSEADSIDSDQEDPLKHAGVYTAEEVALIMREKLIRLQSLYIDQFKRLQHLLKEKKRRYLHNRKVEHEALGSSLLTGPEGLLAKERENLKRLKCLRRYRQRYGVEALLHRQLKERRMLATDGAAQQAHTTRSSQRCLAFVDDVRCSNQSLPMTRHCLTHICQDTNQVLFKCCQGSEEVPCNKPVPVSLSEDPCCPLHFQLPPQMYKPEQVLSVPDDLEAGPMDLYLSAAELQPTESLPLEFSDDLDVVGDGMQCPPSPLLFDPSLTLEDHLVKEIAEDPVDILGQMQMAGDGCRSQGSRNSEKASAPLSQSGLATANGKPEPTSIS

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H9L4-1; Sequence=Displayed; Name=2; IsoId=Q9H9L4-4; Sequence=VSP_042530, VSP_042531

Alternative Sequence

145..155; EDSWSDGEQEP -> MLVSTQQKKWP (in isoform 2); 156..492; Missing (in isoform 2)

3D Structural Models

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

135..144; Basic and acidic residues; 167..178; Acidic residues

Region

126..182; Disordered; 308..364; Required for interaction with other NSL complex members; 455..492; Disordered

Clinical Relevance4

Antibody (2)

HPA038497 HPA038498

Interaction Protein (3)

ENSG00000120071ENSG00000129292ENSG00000196363

Interaction Count

Interaction Dataset (3)

intact_biogrid_bioplexbiogrid_bioplexintact_biogrid

Supporting Publications2

PMID	Title	Abstract
37483339	Neuronally enriched microvesicle RNAs are differentially expressed in the serums of Parkinson's patients.	In serum CD171 enriched exosomes and microvesicles, a panel of 29 smRNAs was expressed differentially between PD and controls (false discovery rate (FDR) < 0.05).
38624007	Label-Free Multiplex Profiling of Exosomal Proteins with a Deep Learning-Driven 3D Surround-Enhancing SERS Platform for Early Cancer Diagnosis.	Combining this 3D se-SERS with a deep learning model, we successfully quantitatively profiled seven proteins including CD63, CD81, CD9, CD151, CD171, TSPAN8, and PD-L1 on the surface of plasma exosomes from patients, which can predict the occurrence and advancement of lung cancer.