Protein detail

JMJD4

2-oxoglutarate and iron-dependent oxygenase JMJD4 (EC 1.14.11.-) (JmjC domain-containing protein 4) (Jumonji domain-containing protein 4) (Lysyl-hydroxylase JMJD4)

Entry name
JMJD4
UniProt ID
Q9H9V9
EVMP confidence score
0.53
Supporting publications (n)
1
Transmembrane count
Protein classification
Predicted intracellular proteins
Basic Information
Protein Names
2-oxoglutarate and iron-dependent oxygenase JMJD4 (EC 1.14.11.-) (JmjC domain-containing protein 4) (Jumonji domain-containing protein 4) (Lysyl-hydroxylase JMJD4)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
ENSG00000081692
Entrez Gene Symbol
JMJD4
Gene Synonym
FLJ12517
Gene Description
Jumonji domain containing 4
Chromosome
1
Position
227730425-227735411
Supporting publications (n)
1
EVMP confidence score
0.53
Fluorescence & Localization
JMJD4 fluorescence
Tissue SpecifickidneyCell SpecificPodocytesSingle-Nuclei Brain Specificendothelial cell
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (3)
Molecular Function (5)
Biological Process (3)
Reactome (3)
Mediation Categories
Metabolism mediation
Relations & Evidence6

Ligand-Receptor Signaling (4)

4 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularComPPI
intracellularintracellularGO_Intercell
intracellularintracellularUniProt_location
intracellularintracellularOmniPath

Protein Complex Composition (1)

1 record.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
HCCSJMJD4PHF23SNX20P53701Q7Z614Q9BUL5Q9H9V90:0:0:0hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyWestern blottingELISA438731868337292552210607137686366
Sequence, Structure & Domains

Sequences

Length
417
Mass
47,425
Sequence
MDRETRALADSHFRGLGVDVPGVGQAPGRVAFVSEPGAFSYADFVRGFLLPNLPCVFSSAFTQGWGSRRRWVTPAGRPDFDHLLRTYGDVVVPVANCGVQEYNSNPKEHMTLRDYITYWKEYIQAGYSSPRGCLYLKDWHLCRDFPVEDVFTLPVYFSSDWLNEFWDALDVDDYRFVYAGPAGSWSPFHADIFRSFSWSVNVCGRKKWLLFPPGQEEALRDRHGNLPYDVTSPALCDTHLHPRNQLAGPPLEITQEAGEMVFVPSGWHHQVHNLDDTISINHNWVNGFNLANMWRFLQQELCAVQEEVSEWRDSMPDWHHHCQVIMRSCSGINFEEFYHFLKVIAEKRLLVLREAAAEDGAGLGFEQAAFDVGRITEVLASLVAHPDFQRVDTSAFSPQPKELLQQLREAVDAAAAP
Alternative Products
Event=Alternative splicing, Alternative initiation; Named isoforms=3; Name=3; IsoId=Q9H9V9-3; Sequence=Displayed; Name=1; IsoId=Q9H9V9-1; Sequence=VSP_062164; Name=2; IsoId=Q9H9V9-2; Sequence=VSP_062165
Alternative Sequence
1; M -> MRAGPEPQALAGQKRGALRLLVPRLVLTVSAPAEVRRRVLRPVLSWM (in isoform 1); 308..323; Missing (in isoform 2)

Domain & Motif Annotations

Domain (FT)
142..301; JmjC
Protein Families
JMJD6 family
Sequence Similarities
Belongs to the JMJD6 family.
Clinical Relevance
Antibody (2)
HPA027260HPA052861
Supporting Publications1
PMIDTitleRelated sentences
32384937Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles.No related sentences available