Protein detail

JMJD4

2-oxoglutarate and iron-dependent oxygenase JMJD4 (EC 1.14.11.-) (JmjC domain-containing protein 4) (Jumonji domain-containing protein 4) (Lysyl-hydroxylase JMJD4)

Entry name JMJD4	UniProt ID Q9H9V9	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

2-oxoglutarate and iron-dependent oxygenase JMJD4 (EC 1.14.11.-) (JmjC domain-containing protein 4) (Jumonji domain-containing protein 4) (Lysyl-hydroxylase JMJD4)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000081692

Entrez Gene Symbol

JMJD4

Gene Synonym

FLJ12517

Gene Description

Jumonji domain containing 4

Chromosome

Position

227730425-227735411

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization4

Tissue SpecifickidneyCell SpecificPodocytesSingle-Nuclei Brain Specificendothelial cell

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (3)

Molecular Function (5)

Biological Process (3)

Reactome (3)

Mediation Categories

Metabolism mediation

Relations & Evidence6

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	HCCS JMJD4 PHF23 SNX20	P53701 Q7Z614 Q9BUL5 Q9H9V9	0:0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Western blottingELISA	4	38731868 33729255 22106071 37686366

Sequence, Structure & Domains8

Sequences

Length

417

Mass

47,425

Sequence

MDRETRALADSHFRGLGVDVPGVGQAPGRVAFVSEPGAFSYADFVRGFLLPNLPCVFSSAFTQGWGSRRRWVTPAGRPDFDHLLRTYGDVVVPVANCGVQEYNSNPKEHMTLRDYITYWKEYIQAGYSSPRGCLYLKDWHLCRDFPVEDVFTLPVYFSSDWLNEFWDALDVDDYRFVYAGPAGSWSPFHADIFRSFSWSVNVCGRKKWLLFPPGQEEALRDRHGNLPYDVTSPALCDTHLHPRNQLAGPPLEITQEAGEMVFVPSGWHHQVHNLDDTISINHNWVNGFNLANMWRFLQQELCAVQEEVSEWRDSMPDWHHHCQVIMRSCSGINFEEFYHFLKVIAEKRLLVLREAAAEDGAGLGFEQAAFDVGRITEVLASLVAHPDFQRVDTSAFSPQPKELLQQLREAVDAAAAP

Alternative Products

Event=Alternative splicing, Alternative initiation; Named isoforms=3; Name=3; IsoId=Q9H9V9-3; Sequence=Displayed; Name=1; IsoId=Q9H9V9-1; Sequence=VSP_062164; Name=2; IsoId=Q9H9V9-2; Sequence=VSP_062165

Alternative Sequence

1; M -> MRAGPEPQALAGQKRGALRLLVPRLVLTVSAPAEVRRRVLRPVLSWM (in isoform 1); 308..323; Missing (in isoform 2)

Domain & Motif Annotations

Domain (FT)

142..301; JmjC

Protein Families

JMJD6 family

Sequence Similarities

Belongs to the JMJD6 family.

Clinical Relevance1

Antibody (2)

HPA027260 HPA052861

Supporting Publications1

PMID	Title	Abstract
32384937	Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles.	No abstract available