Protein detail
GBB4
Guanine nucleotide-binding protein subunit beta-4 (Transducin beta chain 4)
Protein symbol GBB4 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPredicted intracellular proteinsRAS pathway related proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Guanine nucleotide-binding protein subunit beta-4 (Transducin beta chain 4)
Protein Class
Disease related genesHuman disease related genesPredicted intracellular proteinsRAS pathway related proteins
Protein Function
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Disease related genes
- Predicted intracellular proteins
- RAS pathway related proteins
Ensembl
Entrez Gene Symbol
Gene Description
G protein subunit beta 4
Chromosome
3
Position
179396088-179451476
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificadipose tissueBrain Regional Specificchoroid plexusCell SpecificHepatocytesSingle-Nuclei Brain Specificfibroblast
Function & Pathway
Protein Function
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Disease related genes
- Predicted intracellular proteins
- RAS pathway related proteins
Cellular Component
Molecular Function
Biological Process
KEGG
- hsa04014 Ras signaling pathway
- KEGG:hsa04062 Chemokine signaling pathway
- KEGG:hsa04081 Hormone signaling
- KEGG:hsa04082 Neuroactive ligand signaling
- KEGG:hsa04151 PI3K-Akt signaling pathway
- KEGG:hsa04371 Apelin signaling pathway
- KEGG:hsa04713 Circadian entrainment
- KEGG:hsa04723 Retrograde endocannabinoid signaling
- KEGG:hsa04724 Glutamatergic synapse
- KEGG:hsa04725 Cholinergic synapse
- KEGG:hsa04726 Serotonergic synapse
- KEGG:hsa04727 GABAergic synapse
- KEGG:hsa04728 Dopaminergic synapse
- KEGG:hsa04926 Relaxin signaling pathway
- KEGG:hsa05032 Morphine addiction
- KEGG:hsa05034 Alcoholism
- KEGG:hsa05163 Human cytomegalovirus infection
- KEGG:hsa05167 Kaposi sarcoma-associated herpesvirus infection
- KEGG:hsa05170 Human immunodeficiency virus 1 infection
- KEGG:hsa05200 Pathways in cancer
Reactome
- R-hsa-451326 activation of kainate receptors upon glutamate binding
- R-hsa-9660821 adora2b mediated anti inflammatory cytokines production
- R-hsa-418592 adp signalling through p2y purinoceptor 1
- R-hsa-392170 adp signalling through p2y purinoceptor 12
- R-hsa-400042 adrenaline noradrenaline inhibits insulin secretion
- R-hsa-9662851 anti inflammatory response favouring leishmania parasite infection
- R-hsa-445717 aquaporin mediated transport
- R-hsa-3858494 beta catenin independent wnt signaling
- R-hsa-4086398 ca2 pathway
- R-hsa-9855142 cellular responses to mechanical stimuli
- R-hsa-8953897 cellular responses to stimuli
- R-hsa-373080 class b 2 secretin family receptors
- R-hsa-6814122 cooperation of pdcl phlp1 and tric cct in g protein beta folding
- R-hsa-8939211 esr mediated signaling
- R-hsa-9009391 extra nuclear estrogen signaling
- R-hsa-977444 gaba b receptor activation
- R-hsa-977443 gaba receptor activation
- R-hsa-381676 glucagon like peptide 1 glp1 regulates insulin secretion
- R-hsa-163359 glucagon signaling in metabolic regulation
- R-hsa-420092 glucagon type ligand receptors
- R-hsa-500792 gpcr ligand binding
- R-hsa-9634597 gper1 signaling
- R-hsa-416482 g alpha 12 13 signalling events
- R-hsa-418594 g alpha i signalling events
- R-hsa-416476 g alpha q signalling events
- R-hsa-418555 g alpha s signalling events
- R-hsa-418597 g alpha z signalling events
- R-hsa-8964616 g beta gamma signalling through cdc42
- R-hsa-392451 g beta gamma signalling through pi3kgamma
- R-hsa-202040 g protein activation
- R-hsa-397795 g protein beta gamma signalling
- R-hsa-109582 hemostasis
- R-hsa-9856530 high laminar flow shear stress activates signaling by piezo1 and pecam1 cdh5 kdr in endothelial cells
- R-hsa-5663205 infectious disease
- R-hsa-163685 integration of energy metabolism
- R-hsa-1296065 inwardly rectifying k channels
- R-hsa-9658195 leishmania infection
- R-hsa-112316 neuronal system
- R-hsa-112314 neurotransmitter receptors and postsynaptic signal transmission
- R-hsa-111885 opioid signalling
- R-hsa-76002 platelet activation signaling and aggregation
- R-hsa-418346 platelet homeostasis
- R-hsa-1296071 potassium channels
- R-hsa-500657 presynaptic function of kainate receptors
- R-hsa-392851 prostacyclin signalling through prostacyclin receptor
- R-hsa-391251 protein folding
- R-hsa-422356 regulation of insulin secretion
- R-hsa-372790 signaling by gpcr
- R-hsa-9006931 signaling by nuclear receptors
- R-hsa-195721 signaling by wnt
- R-hsa-392518 signal amplification
- R-hsa-456926 thrombin signalling through proteinase activated receptors pars
- R-hsa-428930 thromboxane signalling through tp receptor
- R-hsa-112315 transmission across chemical synapses
- R-hsa-382551 transport of small molecules
- R-hsa-432040 vasopressin regulates renal water homeostasis via aquaporins
Mediation Categories
Fusion and delivery mediationImmune mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| GNAI1-GNB4-GNG12 complex | GNAI1GNB4GNG12 | P63096Q9HAV0Q9UBI6 | 0:0:0 | CORUM | CORUM:7089 | 25733868 |
| GNAI1-GNB4-GNG13 complex | GNAI1GNB4GNG13 | P63096Q9HAV0Q9P2W3 | 0:0:0 | CORUM | CORUM:7095 | 25733868 |
| GNAI1-GNB4-GNG4 complex | GNAI1GNB4GNG4 | P50150P63096Q9HAV0 | 0:0:0 | CORUM | CORUM:7034 | 25733868 |
| GNAI1-GNB4-GNG8 complex | GNAI1GNB4GNG8 | P63096Q9HAV0Q9UK08 | 0:0:0 | CORUM | CORUM:7074 | 25733868 |
| GNAI1-GNB4-GNGT1 complex | GNAI1GNB4GNGT1 | P63096P63211Q9HAV0 | 0:0:0 | CORUM | CORUM:7017 | 25733868 |
Sequence, Structure & Domains
Sequences
Length
340
Mass
37,567
Sequence
MSELEQLRQEAEQLRNQIQDARKACNDATLVQITSNMDSVGRIQMRTRRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN
3D Structural Models
Domain & Motif Annotations
Repeat
53..92; WD 1; 95..134; WD 2; 141..179; WD 3; 182..221; WD 4; 224..263; WD 5; 268..307; WD 6; 310..339; WD 7
Protein Families
WD repeat G protein beta family
Sequence Similarities
Belongs to the WD repeat G protein beta family.