Protein detail
CDHR5
Cadherin-related family member 5 (Mu-protocadherin) (Mucin and cadherin-like protein) (Mucin-like protocadherin) (MLPCDH)
Protein symbol CDHR5 | UniProt ID | EVMP score 0.38 |
Frequency | Transmembrane count 1 | Protein classification Plasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
Basic Information
Protein Names
Cadherin-related family member 5 (Mu-protocadherin) (Mucin and cadherin-like protein) (Mucin-like protocadherin) (MLPCDH)
Protein Class
Plasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
Predicted intracellular proteins
Transmembrane
670..690; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
FLJ20219MU-PCDHMUCDHLMUPCDH
Gene Description
Cadherin related family member 5
Chromosome
11
Position
616577-626078
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificEndometrial glandular cellsBlood Cell Specificnaive CD8 T-cellBlood Lineage SpecificT-cells
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
31 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| cadherin_related | cell_adhesion | HGNC | Yes | Yes | No | Yes | No |
| adhesion | adhesion | HGNC | Yes | Yes | No | Yes | No |
| adhesion | adhesion | MCAM | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | Zhong2015 | Yes | Yes | No | Yes | No |
| icam | cell_adhesion | Zhong2015 | Yes | Yes | No | Yes | No |
| protocadherin | cell_adhesion | Almen2009 | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | Almen2009 | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | HGNC | Yes | Yes | No | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometryR Sequencing | 1 | 34992371 |
Sequence, Structure & Domains
Sequences
Length
845
Mass
88,223
Sequence
MGSWALLWPPLLFTGLLVRPPGTMAQAQYCSVNKDIFEVEENTNVTEPLVDIHVPEGQEVTLGALSTPFAFRIQGNQLFLNVTPDYEEKSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVPSPMTFLLLVKGQQADLARYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRIQAQDPEFSDLNSAITYRITNHSHFRMEGEVVLTTTTLAQAGAFYAEVEAHNTVTSGTATTVIEIQVSEQEPPSTDVPPSPEAGGTTGPWTSTTSEVPRPPEPSQGPSTTSSGGGTGPHPPSGTTLRPPTSSTPGGPPGAENSTSHQPATPGGDTAQTPKPGTSQPMPPGVGTSTSHQPATPSGGTAQTPEPGTSQPMPPSMGTSTSHQPATPGGGTAQTPEAGTSQPMPPGMGTSTSHQPTTPGGGTAQTPEPGTSQPMPLSKSTPSSGGGPSEDKRFSVVDMAALGGVLGALLLLALLGLAVLVHKHYGPRLKCCCGKAPEPQPQGFDNQAFLPDHKANWAPVPSPTHDPKPAEAPMPAEPAPPGPASPGGAPEPPAAARAGGSPTAVRSILTKERRPEGGYKAVWFGEDIGTEADVVVLNAPTLDVDGASDSGSGDEGEGAGRGGGPYDAPGGDDSYI
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=MUCDHL-FL, MLPCDH-L; IsoId=Q9HBB8-1; Sequence=Displayed; Name=2; Synonyms=MLPCDH-S; IsoId=Q9HBB8-2; Sequence=VSP_050693; Name=3; IsoId=Q9HBB8-4; Sequence=VSP_050692
Alternative Sequence
460..653; Missing (in isoform 2); 460..465; Missing (in isoform 3)
3D Structural Models
Turn
68..70; 86..88; 193..195
Helix
146..149; 171..173
Beta Strand
36..40; 49..51; 59..62; 71..74; 77..80; 90..100; 103..115; 127..134; 142..144; 161..168; 175..179; 182..187; 197..209; 218..228
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
506..518; Low complexity; 539..549; Polar residues; 556..594; Polar residues; 602..611; Polar residues; 633..652; Low complexity; 729..762; Pro residues; 835..845; Low complexity
Repeat
540..570; 1; 571..601; 2; 602..631; 3; 632..645; 4; truncated
Domain (FT)
71..124; Cadherin 1; 125..237; Cadherin 2; 249..354; Cadherin 3; 355..459; Cadherin 4
Region
452..661; Disordered; 540..645; 4 X 31 AA approximate tandem repeats; 691..845; Mediates interaction with USH1C and MYO7B and is required for proper localization to microvilli tips and function in microvilli organization; 724..789; Disordered; 811..845; Disordered