Protein detail

IL21R

Interleukin-21 receptor (IL-21 receptor) (IL-21R) (Novel interleukin receptor) (CD antigen CD360)

Entry name IL21R	UniProt ID Q9HBE5	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 1	Protein classification Cancer-related genesCD markersDisease related genesHuman disease related genesPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Interleukin-21 receptor (IL-21 receptor) (IL-21R) (Novel interleukin receptor) (CD antigen CD360)

Protein Class (5)

Cancer-related genesCD markersDisease related genesHuman disease related genesPredicted membrane proteins

Protein Function (4)

Human disease related genes:Immune system diseases:Primary immunodeficiency
Disease related genes
CD markers
Cancer-related genes

Transmembrane

233..253; Helical

Transmembrane Count

Ensembl

ENSG00000103522

Entrez Gene Symbol

IL21R

Gene Synonym

CD360

Gene Description

Interleukin 21 receptor

Chromosome

Position

27402174-27452042

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization6

Tissue SpecificbrainBrain Regional SpecificcerebellumSingle-Nuclei Brain Specificupper rhombic lipSecretome LocationSecreted to extracellular matrixSecretome FunctionCell adhesion

Function & Pathway7

Protein Function (4)

Human disease related genes:Immune system diseases:Primary immunodeficiency
Disease related genes
CD markers
Cancer-related genes

Cellular Component (3)

Molecular Function (4)

Biological Process (3)

KEGG (4)

Reactome (4)

Mediation Categories (3)

Clinical-translation mediationFusion and delivery mediationImmune mediation

Relations & Evidence60

Ligand-Receptor Signaling (54)

54 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellPhoneDB	No	Yes	No	Yes	No
receptor	receptor	GO_Intercell	No	Yes	No	Yes	No
receptor	receptor	HPMR	No	Yes	No	Yes	No
receptor	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	CellTalkDB	No	Yes	No	Yes	No
receptor	receptor	Surfaceome	No	Yes	No	Yes	No
receptor	receptor	Ramilowski2015	No	Yes	No	Yes	No
receptor	receptor	Guide2Pharma	No	Yes	No	Yes	No
receptor	receptor	LRdb	No	Yes	No	Yes	No
receptor	receptor	Baccin2019	No	Yes	No	Yes	No

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Regulatory Interaction Network (3)

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
IL21R	Q9HBE5	JAK1	P23458	Yes	Yes	No	InnateDB_SignaLink3SIGNORHPRDHINTSignaLink3InnateDBWang	SignaLink3:11418623 HPRD:11016959 InnateDB:11016959 HINT:11016959 SignaLink3:11016959 HINT:11418623 SIGNOR:12093291 SignaLink3:23180781 SignaLink3:23331499 HPRD:11418623
IL21	Q9HBE4	IL21R	Q9HBE5	Yes	Yes	No	iTALKSIGNORHINTSignaLink3UniProt_LRdbHPMR_talklrHPMRHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbHPRD_talklrBaccin2019STRING_talklrCellCallGuide2PharmaFantom5_LRdbCellTalkDBconnectomeDB2020LRdb	SignaLink3:18988627 SignaLink3:11418623 connectomeDB2020:11418623 HINT:22235133 HPMR:11418623 HPRD:11418623 SignaLink3:16424177 SignaLink3:23331499 HINT:37339051 SIGNOR:16424177 LRdb:11418623 CellTalkDB:11418623 SignaLink3:21071413Baccin2019:1141862311418620
IL21R	Q9HBE5	JAK3	P52333	Yes	Yes	No	WangSIGNORSignaLink3	SignaLink3:12093291 SIGNOR:12093291 SignaLink3:23331499

Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	IL21 IL21R	Q9HBE4 Q9HBE5	8:8	PDB	PDB:3tgx
	IL21R	Q9HBE5	3	PDB	PDB:4nzd

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry；RNA Sequencing；Flow cytometry	1	41307968

Sequence, Structure & Domains13

Sequences

Length

538

Mass

59,130

Sequence

MPRGWAAPLLLLLLQGGWGCPDLVCYTDYLQTVICILEMWNLHPSTLTLTWQDQYEELKDEATSCSLHRSAHNATHATYTCHMDVFHFMADDIFSVNITDQSGNYSQECGSFLLAESIKPAPPFNVTVTFSGQYNISWRSDYEDPAFYMLKGKLQYELQYRNRGDPWAVSPRRKLISVDSRSVSLLPLEFRKDSSYELQVRAGPMPGSSYQGTWSEWSDPVIFQTQSEELKEGWNPHLLLLLLLVIVFIPAFWSLKTHPLWRLWKKIWAVPSPERFFMPLYKGCSGDFKKWVGAPFTGSSLELGPWSPEVPSTLEVYSCHPPRSPAKRLQLTELQEPAELVESDGVPKPSFWPTAQNSGGSAYSEERDRPYGLVSIDTVTVLDAEGPCTWPCSCEDDGYPALDLDAGLEPSPGLEDPLLDAGTTVLSCGCVSAGSPGLGGPLGSLLDRLKPPLADGEDWAGGLPWGGRSPGGVSESEAGSPLAGLDMDTFDSGFVGSDCSSPVECDFTSPGDEGPPRSYLRQWVVIPPPLSSPGPQAS

3D Structural Models

Turn

206..209

Helix

85..87; 114..116; 141..143; 145..150; 187..189

Beta Strand

24..27; 29..38; 41..43; 46..52; 57..59; 64..72; 74..82; 93..99; 101..104; 106..113; 124..127; 130..139; 154..165; 172..176; 181..185; 195..204; 221..224

3D Structure

X-ray crystallography (5)

Domain & Motif Annotations

Motif

214..218; WSXWS motif; 266..274; Box 1 motif

Domain (CC)

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.; DOMAIN: The box 1 motif is required for JAK interaction and/or activation.

Domain (FT)

21..118; Fibronectin type-III 1; 119..228; Fibronectin type-III 2

Region

342..367; Disordered; 457..487; Disordered

Protein Families (2)

Type I cytokine receptor family
Type 4 subfamily

Sequence Similarities

Belongs to the type I cytokine receptor family. Type 4 subfamily.

Clinical Relevance5

Disease Involvement (2)

Cancer-related genesDisease variant

Related Diseases (3)

Crohn disease Postoperative inflammation Solid tumour/cancer

Biomarker

Phase 1; Phase 2

Drugs (4)

RIBAVIRIN PEGINTERFERON ALFA-2B NULL DENENICOKIN

Antibody

HPA042296

Supporting Publications1

PMID	Title	Abstract
32795414	Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers.	Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers.