Protein detail
PARVB
Beta-parvin (Affixin)
Entry name PARVB | UniProt ID | EVMP confidence score 0.75 |
Supporting publications (n) 55 | Transmembrane count | Protein classification Cancer-related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Beta-parvin (Affixin)
Protein Class (4)
Cancer-related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function (2)
- Cancer-related genes:Candidate cancer biomarkers
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
CGI-56
Gene Description
Parvin beta
Chromosome
22
Position
43999211-44172939
Supporting publications (n)
55
EVMP confidence score
0.75
Fluorescence & Localization
Function & Pathway
Protein Function (2)
- Cancer-related genes:Candidate cancer biomarkers
- Predicted intracellular proteins
Cellular Component (7)
Molecular Function (2)
Biological Process (3)
Reactome (4)
Mediation Categories (2)
Adhesion and uptake mediationReceptor-signaling mediation
Relations & Evidence25
Ligand-Receptor Signaling (12)
12 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | |||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| parin_adhesion_regulator | intracellular_intercellular_related | HGNC | Yes | ||||
| adhesion_cytoskeleton_adaptor | intracellular_intercellular_related | Adhesome | Yes | ||||
| intracellular_intercellular_related | intracellular_intercellular_related | OmniPath | Yes | ||||
| transmembrane | transmembrane | Ramilowski_location | |||||
| transmembrane | transmembrane | OmniPath |
Page 1 of 2Next
Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| ILK | Q13418 | PARVB | Q9HBI1 | Yes | Yes | WangAdhesomePhosphoPointSIGNORHPRDHINTIntActSPIKE_LC | HPRD:15467740SPIKE_LC:17145710HINT:32707033HINT:11402068Adhesome:11402068Adhesome:23612611HINT:15467740HINT:17353931Adhesome:18325335HINT:35271311Adhesome:10592173SPIKE_LC:17353931HINT:26496610HINT:33961781IntAct:17353931Adhesome:19798050Adhesome:17353931Adhesome:15467740HPRD:11402068SIGNOR:15159419 |
Protein Complex Composition (11)
Isolation & Detection Technology (1)
1 record.
Sequence, Structure & Domains
Sequences
Length
364
Mass
41,714
Sequence
MSSAPRSPTPRPRRMKKDESFLGKLGGTLARKRRAREVSDLQEEGKNAINSPMSPALVDVHPEDTQLEENEERTMIDPTSKEDPKFKELVKVLLDWINDVLVEERIIVKQLEEDLYDGQVLQKLLEKLAGCKLNVAEVTQSEIGQKQKLQTVLEAVHDLLRPRGWALRWSVDSIHGKNLVAILHLLVSLAMHFRAPIRLPEHVTVQVVVVRKREGLLHSSHISEELTTTTEMMMGRFERDAFDTLFDHAPDKLSVVKKSLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEDYFVPLHHFYLTPESFDQKVHNVSFAFELMLDGGLKKPKARPEDVVNLDLKSTLRVLYNLFTKYKNVE
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9HBI1-1; Sequence=Displayed; Name=2; IsoId=Q9HBI1-2; Sequence=VSP_041336; Name=3; IsoId=Q9HBI1-3; Sequence=VSP_045555
Alternative Sequence
1..38; MSSAPRSPTPRPRRMKKDESFLGKLGGTLARKRRAREV -> M (in isoform 3); 1..37; MSSAPRSPTPRPRRMKKDESFLGKLGGTLARKRRARE -> MHHVFKDHQRGEKRGFLSPENKNCRRLELRRGCSCSWGLCSQALMASLAGSLLPGSDRSGVETSEYAQGG (in isoform 2)
3D Structural Models
Turn
278..284
Helix
243..246; 250..252; 254..268; 269..271; 286..295; 302..304; 312..328; 338..342; 346..360
3D Structure
X-ray crystallography (3)
Domain & Motif Annotations
Compositional Bias
36..46; Basic and acidic residues
Domain (FT)
87..194; Calponin-homology (CH) 1; 254..361; Calponin-homology (CH) 2
Region
1..57; Disordered
Protein Families
Parvin family
Sequence Similarities
Belongs to the parvin family.
Clinical Relevance
Supporting Publications55
| PMID | Title | Related sentences |
|---|---|---|
| 10451508 | Simultaneous analysis of the cyan, yellow and green fluorescent proteins by flow cytometry using single-laser excitation at 458 nm. | No related sentences available |
| 22329422 | Quantitative proteome profiling of normal human circulating microparticles. | No related sentences available |
| 24069378 | Proteome profiling of neuroblastoma-derived exosomes reveal the expression of proteins potentially involved in tumor progression. | We found that the large majority of the proteins identified in NB derived exosomes are present in Exocarta database including tetraspanins, fibronectin, heat shock proteins, MVB proteins, cytoskeleton-related proteins, prominin-1 (CD133), basigin (CD147) and B7-H3 (CD276). |
| 24657793 | Plasma biomarker discovery in preeclampsia using a novel differential isolation technology for circulating extracellular vesicles. | No related sentences available |
| 25844599 | Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel. | No related sentences available |
| 26775013 | Proteomic characterization of circulating extracellular vesicles identifies novel serum myeloma associated markers. | No related sentences available |
| 27723984 | Proteomic and Bioinformatic Characterization of Extracellular Vesicles Released from Human Macrophages upon Influenza A Virus Infection. | No related sentences available |
| 28242843 | Label-free Proteomic Analysis of Exosomes Derived from Inducible Hepatitis B Virus-Replicating HepAD38 Cell Line. | No related sentences available |
| 28396511 | Database-augmented Mass Spectrometry Analysis of Exosomes Identifies Claudin 3 as a Putative Prostate Cancer Biomarker. | No related sentences available |
| 29242380 | Insights into the Proteome of Gastrointestinal Stromal Tumors-Derived Exosomes Reveals New Potential Diagnostic Biomarkers. | No related sentences available |
Page 1 of 6Next