Protein detail
PARVB
Beta-parvin (Affixin)
Entry name PARVB | UniProt ID | EVMP confidence score 0.88 |
Supporting publications (n) 55 | Transmembrane count | Protein classification Cancer-related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Beta-parvin (Affixin)
Protein Class (4)
Cancer-related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function (2)
- Cancer-related genes:Candidate cancer biomarkers
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
CGI-56
Gene Description
Parvin beta
Chromosome
22
Position
43999211-44172939
Supporting publications (n)
55
EVMP confidence score
0.88
Fluorescence & Localization1
Function & Pathway7
Protein Function (2)
- Cancer-related genes:Candidate cancer biomarkers
- Predicted intracellular proteins
Cellular Component (7)
Molecular Function (2)
Biological Process (3)
Reactome (4)
Mediation Categories (2)
Adhesion and uptake mediationReceptor-signaling mediation
Relations & Evidence25
Ligand-Receptor Signaling (12)
12 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| parin_adhesion_regulator | intracellular_intercellular_related | HGNC | Yes | No | No | No | No |
| adhesion_cytoskeleton_adaptor | intracellular_intercellular_related | Adhesome | Yes | No | No | No | No |
| intracellular_intercellular_related | intracellular_intercellular_related | OmniPath | Yes | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
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Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| ILK | Q13418 | PARVB | Q9HBI1 | Yes | Yes | No | WangAdhesomePhosphoPointSIGNORHPRDHINTIntActSPIKE_LC | HPRD:15467740SPIKE_LC:17145710HINT:32707033HINT:11402068Adhesome:11402068Adhesome:23612611HINT:15467740HINT:17353931Adhesome:18325335HINT:35271311Adhesome:10592173SPIKE_LC:17353931HINT:26496610HINT:33961781IntAct:17353931Adhesome:19798050Adhesome:17353931Adhesome:15467740HPRD:11402068SIGNOR:15159419 |
Protein Complex Composition (11)
11 records.
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Isolation & Detection Technology (1)
1 record.
Sequence, Structure & Domains13
Sequences
Length
364
Mass
41,714
Sequence
MSSAPRSPTPRPRRMKKDESFLGKLGGTLARKRRAREVSDLQEEGKNAINSPMSPALVDVHPEDTQLEENEERTMIDPTSKEDPKFKELVKVLLDWINDVLVEERIIVKQLEEDLYDGQVLQKLLEKLAGCKLNVAEVTQSEIGQKQKLQTVLEAVHDLLRPRGWALRWSVDSIHGKNLVAILHLLVSLAMHFRAPIRLPEHVTVQVVVVRKREGLLHSSHISEELTTTTEMMMGRFERDAFDTLFDHAPDKLSVVKKSLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEDYFVPLHHFYLTPESFDQKVHNVSFAFELMLDGGLKKPKARPEDVVNLDLKSTLRVLYNLFTKYKNVE
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9HBI1-1; Sequence=Displayed; Name=2; IsoId=Q9HBI1-2; Sequence=VSP_041336; Name=3; IsoId=Q9HBI1-3; Sequence=VSP_045555
Alternative Sequence
1..38; MSSAPRSPTPRPRRMKKDESFLGKLGGTLARKRRAREV -> M (in isoform 3); 1..37; MSSAPRSPTPRPRRMKKDESFLGKLGGTLARKRRARE -> MHHVFKDHQRGEKRGFLSPENKNCRRLELRRGCSCSWGLCSQALMASLAGSLLPGSDRSGVETSEYAQGG (in isoform 2)
3D Structural Models
Turn
278..284
Helix
243..246; 250..252; 254..268; 269..271; 286..295; 302..304; 312..328; 338..342; 346..360
3D Structure
X-ray crystallography (3)
Domain & Motif Annotations
Compositional Bias
36..46; Basic and acidic residues
Domain (FT)
87..194; Calponin-homology (CH) 1; 254..361; Calponin-homology (CH) 2
Region
1..57; Disordered
Protein Families
Parvin family
Sequence Similarities
Belongs to the parvin family.
Clinical Relevance5
Supporting Publications55
| PMID | Title | Abstract |
|---|---|---|
| 33017416 | Proteomic analysis of plasma exosomes from Cystic Echinococcosis patients provides in vivo support for distinct immune response profiles in active vs inactive infection and suggests potential biomarkers. | No abstract available |
| 33023655 | Trastuzumab-induced upregulation of a protein set in extracellular vesicles emitted by ErbB2-positive breast cancer cells correlates with their trastuzumab sensitivity. | No abstract available |
| 34202855 | Proteomic Profiling of Ectosomes Derived from Paired Urothelial Bladder Cancer and Normal Cells Reveals the Presence of Biologically-Relevant Molecules. | No abstract available |
| 34401050 | TPI1-reduced extracellular vesicles mediated by Rab20 downregulation promotes aerobic glycolysis to drive hepatocarcinogenesis. | No abstract available |
| 34681663 | Proteomic Landscape of Extracellular Vesicles for Diffuse Large B-Cell Lymphoma Subtyping. | No abstract available |
| 34754007 | Plasma extracellular vesicles in people living with HIV and type 2 diabetes are related to microbial translocation and cardiovascular risk. | No abstract available |
| 34876625 | Plasma-derived candidate biomarkers for detection of gallbladder carcinoma. | No abstract available |
| 35111156 | Exosomes Recovered From the Plasma of COVID-19 Patients Expose SARS-CoV-2 Spike-Derived Fragments and Contribute to the Adaptive Immune Response. | No abstract available |
| 36362114 | Extracellular Vesicles in Diffuse Large B Cell Lymphoma: Characterization and Diagnostic Potential. | No abstract available |
| 36406491 | Automated Proteomics Sample Preparation of Phosphatidylserine-Positive Extracellular Vesicles from Human Body Fluids. | No abstract available |