Protein detail

LGR6

Leucine-rich repeat-containing G-protein coupled receptor 6

Entry name LGR6	UniProt ID Q9HBX8	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 7	Protein classification G-protein coupled receptorsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Leucine-rich repeat-containing G-protein coupled receptor 6

Protein Class (4)

G-protein coupled receptorsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Protein Function (2)

Predicted intracellular proteins
G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

568..588; Helical; Name=1; 599..619; Helical; Name=2; 645..665; Helical; Name=3; 688..708; Helical; Name=4; 728..748; Helical; Name=5; 775..795; Helical; Name=6; 810..830; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000133067

Entrez Gene Symbol

LGR6

Gene Synonym

FLJ14471

Gene Description

Leucine rich repeat containing G protein-coupled receptor 6

Chromosome

Position

202193799-202319781

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization1

Function & Pathway7

Protein Function (2)

Predicted intracellular proteins
G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component (3)

Molecular Function (5)

Biological Process (3)

KEGG

hsa04310 Wnt signaling pathway

Reactome (3)

Mediation Categories (2)

Fusion and delivery mediationReceptor-signaling mediation

Relations & Evidence55

Ligand-Receptor Signaling (54)

54 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	HGNC	No	Yes	No	Yes	No
receptor	receptor	CellPhoneDB	No	Yes	No	Yes	No
receptor	receptor	HPMR	No	Yes	No	Yes	No
receptor	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	CellTalkDB	No	Yes	No	Yes	No
receptor	receptor	Surfaceome	No	Yes	No	Yes	No
receptor	receptor	Ramilowski2015	No	Yes	No	Yes	No
receptor	receptor	Guide2Pharma	No	Yes	No	Yes	No
gpcr	receptor	DGIdb	No	Yes	No	Yes	No
receptor	receptor	LRdb	No	Yes	No	Yes	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	ELISA	2	37322475 41307968

Sequence, Structure & Domains9

Sequences

Length

967

Mass

104,298

Sequence

MPSPPGLRALWLCAALCASRRAGGAPQPGPGPTACPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLILEASEAGRPPGLETYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAGGGLSGGGGFQPSGLAFASHV

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=3; IsoId=Q9HBX8-3; Sequence=Displayed; Name=1; IsoId=Q9HBX8-1; Sequence=VSP_028006, VSP_028007; Name=2; IsoId=Q9HBX8-2; Sequence=VSP_013596

Alternative Sequence

1..71; MPSPPGLRALWLCAALCASRRAGGAPQPGPGPTACPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYL -> MRLEGEGRSARAGQNLSRAGSARRGAPR (in isoform 1); 1..71; MPSPPGLRALWLCAALCASRRAGGAPQPGPGPTACPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYL -> MGRPRLTLVCQVSIIISAR (in isoform 2); 144..239; Missing (in isoform 1)

Domain & Motif Annotations

Repeat

91..112; LRR 1; 115..136; LRR 2; 139..160; LRR 3; 163..186; LRR 4; 187..208; LRR 5; 211..232; LRR 6; 235..256; LRR 7; 258..279; LRR 8; 282..303; LRR 9; 306..328; LRR 10; 329..350; LRR 11; 353..374; LRR 12; 375..396; LRR 13; 399..420; LRR 14; 423..443; LRR 15

Domain (FT)

26..66; LRRNT

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance3

Disease Involvement

Tumor suppressor

Drugs (4)

R-SPONDIN-3 R-SPONDIN-4 R-SPONDIN-2 R-SPONDIN-1

Antibody

HPA008556

Supporting Publications1

PMID	Title	Abstract
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available