Protein detail
PCD18
Protocadherin-18
Entry name PCD18 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 6 | Transmembrane count 1 | Protein classification Predicted intracellular proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Protocadherin-18
Protein Class (2)
Predicted intracellular proteinsPredicted membrane proteins
Protein Function
Predicted intracellular proteins
Transmembrane
700..720; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
KIAA1562PCDH68L
Gene Description
Protocadherin 18
Chromosome
4
Position
137518918-137532494
Supporting publications (n)
6
EVMP confidence score
0.38
Fluorescence & Localization4
Cell SpecificDecidual stromal cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificNK-cellBlood Lineage Specificdendritic cells
Function & Pathway6
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function (2)
Biological Process (3)
Mediation Categories
Adhesion and uptake mediation
Relations & Evidence32
Ligand-Receptor Signaling (31)
31 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | LOCATE | No | No | No | Yes | No |
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| non_clustered_protocadherin | cell_adhesion | HGNC | Yes | Yes | No | Yes | No |
| adhesion | adhesion | HGNC | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | Zhong2015 | Yes | Yes | No | Yes | No |
| icam | cell_adhesion | Zhong2015 | Yes | Yes | No | Yes | No |
| protocadherin | cell_adhesion | Almen2009 | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | Almen2009 | Yes | Yes | No | Yes | No |
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Isolation & Detection Technology (1)
Sequence, Structure & Domains12
Sequences
Length
1,135
Mass
126,149
Sequence
MHQMNAKMHFRFVFALLIVSFNHDVLGKNLKYRIYEEQRVGSVIARLSEDVADVLLKLPNPSTVRFRAMQRGNSPLLVVNEDNGEISIGATIDREQLCQKNLNCSIEFDVITLPTEHLQLFHIEVEVLDINDNSPQFSRSLIPIEISESAAVGTRIPLDSAFDPDVGENSLHTYSLSANDFFNIEVRTRTDGAKYAELIVVRELDRELKSSYELQLTASDMGVPQRSGSSILKISISDSNDNSPAFEQQSYIIQLLENSPVGTLLLDLNATDPDEGANGKIVYSFSSHVSPKIMETFKIDSERGHLTLFKQVDYEITKSYEIDVQAQDLGPNSIPAHCKIIIKVVDVNDNKPEININLMSPGKEEISYIFEGDPIDTFVALVRVQDKDSGLNGEIVCKLHGHGHFKLQKTYENNYLILTNATLDREKRSEYSLTVIAEDRGTPSLSTVKHFTVQINDINDNPPHFQRSRYEFVISENNSPGAYITTVTATDPDLGENGQVTYTILESFILGSSITTYVTIDPSNGAIYALRIFDHEEVSQITFVVEARDGGSPKQLVSNTTVVLTIIDENDNVPVVIGPALRNNTAEITIPKGAESGFHVTRIRAIDRDSGVNAELSCAIVAGNEENIFIIDPRSCDIHTNVSMDSVPYTEWELSVIIQDKGNPQLHTKVLLKCMIFEYAESVTSTAMTSVSQASLDVSMIIIISLGAICAVLLVIMVLFATRCNREKKDTRSYNCRVAESTYQHHPKRPSRQIHKGDITLVPTINGTLPIRSHHRSSPSSSPTLERGQMGSRQSHNSHQSLNSLVTISSNHVPENFSLELTHATPAVEQVSQLLSMLHQGQYQPRPSFRGNKYSRSYRYALQDMDKFSLKDSGRGDSEAGDSDYDLGRDSPIDRLLGEGFSDLFLTDGRIPAAMRLCTEECRVLGHSDQCWMPPLPSPSSDYRSNMFIPGEEFPTQPQQQHPHQSLEDDAQPADSGEKKKSFSTFGKDSPNDEDTGDTSTSSLLSEMSSVFQRLLPPSLDTYSECSEVDRSNSLERRKGPLPAKTVGYPQGVAAWAASTHFQNPTTNCGPPLGTHSSVQPSSKWLPAMEEIPENYEEDDFDNVLNHLNDGKHELMDASELVAEINKLLQDVRQS
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9HCL0-1; Sequence=Displayed; Name=2; IsoId=Q9HCL0-2; Sequence=VSP_035648
Alternative Sequence
830; Missing (in isoform 2)
3D Structural Models
Turn
81..83; 206..208; 301..303; 314..316; 425..427
Helix
47..50; 52..55; 61..63; 94..98; 167..169; 276..279; 291..296; 390..393
Beta Strand
29..35; 43..46; 58..60; 65..69; 76..79; 85..88; 105..115; 120..128; 140..147; 155..157; 170..176; 180..188; 194..200; 211..220; 227..237; 245..247; 249..256; 264..267; 281..285; 297..299; 305..310; 319..330; 336..345; 353..357; 380..385; 395..399; 405..411; 414..419; 430..440; 446..454
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
791..800; Polar residues; 869..878; Basic and acidic residues; 1028..1039; Basic and acidic residues
Domain (FT)
28..137; Cadherin 1; 138..246; Cadherin 2; 247..354; Cadherin 3; 361..465; Cadherin 4; 466..576; Cadherin 5; 582..688; Cadherin 6
Region
769..800; Disordered; 869..889; Disordered; 893..1135; Interaction with DAB1; 942..1003; Disordered; 1023..1046; Disordered
Clinical Relevance1
Antibody
Supporting Publications6
| PMID | Title | Abstract |
|---|---|---|
| 33592500 | A Proteomic Approach to Understand the Clinical Significance of Acute Myeloid Leukemia-Derived Extracellular Vesicles Reflecting Essential Characteristics of Leukemia. | No abstract available |
| 37322475 | Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration. | No abstract available |
| 38113368 | In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum. | No abstract available |
| 38607062 | Enrichment, Characterization, and Proteomic Profiling of Small Extracellular Vesicles Derived from Human Limbal Mesenchymal Stromal Cells and Melanocytes. | No abstract available |
| 41068253 | Identification of plasma extracellular vesicle protein biomarkers in diabetic retinopathy progression. | No abstract available |
| 41307968 | Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System. | No abstract available |