Protein detail

PCD18

Protocadherin-18

Entry name PCD18	UniProt ID Q9HCL0	EVMP confidence score 0.38
Supporting publications (n) 6	Transmembrane count 1	Protein classification Predicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Protocadherin-18

Protein Class (2)

Predicted intracellular proteinsPredicted membrane proteins

Protein Function

Predicted intracellular proteins

Transmembrane

700..720; Helical

Transmembrane Count

Ensembl

ENSG00000189184

Entrez Gene Symbol

PCDH18

Gene Synonym (2)

KIAA1562PCDH68L

Gene Description

Protocadherin 18

Chromosome

Position

137518918-137532494

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization4

Cell SpecificDecidual stromal cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificNK-cellBlood Lineage Specificdendritic cells

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component

GO:0005886 plasma membrane

Molecular Function (2)

Biological Process (3)

KEGG

hsa04519 Cadherin signaling

Mediation Categories

Adhesion and uptake mediation

Relations & Evidence32

Ligand-Receptor Signaling (31)

31 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No
transmembrane_phobius	transmembrane_predicted	Almen2009	No	No	No	Yes	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity CaptureMicrofluidics-Based Methods	Mass spectrometry	11	29148239 39766158 31508500 36398564 38225453 38556629 40945317 40545963 38731868 39569406 40091455

Sequence, Structure & Domains12

Sequences

Length

1,135

Mass

126,149

Sequence

MHQMNAKMHFRFVFALLIVSFNHDVLGKNLKYRIYEEQRVGSVIARLSEDVADVLLKLPNPSTVRFRAMQRGNSPLLVVNEDNGEISIGATIDREQLCQKNLNCSIEFDVITLPTEHLQLFHIEVEVLDINDNSPQFSRSLIPIEISESAAVGTRIPLDSAFDPDVGENSLHTYSLSANDFFNIEVRTRTDGAKYAELIVVRELDRELKSSYELQLTASDMGVPQRSGSSILKISISDSNDNSPAFEQQSYIIQLLENSPVGTLLLDLNATDPDEGANGKIVYSFSSHVSPKIMETFKIDSERGHLTLFKQVDYEITKSYEIDVQAQDLGPNSIPAHCKIIIKVVDVNDNKPEININLMSPGKEEISYIFEGDPIDTFVALVRVQDKDSGLNGEIVCKLHGHGHFKLQKTYENNYLILTNATLDREKRSEYSLTVIAEDRGTPSLSTVKHFTVQINDINDNPPHFQRSRYEFVISENNSPGAYITTVTATDPDLGENGQVTYTILESFILGSSITTYVTIDPSNGAIYALRIFDHEEVSQITFVVEARDGGSPKQLVSNTTVVLTIIDENDNVPVVIGPALRNNTAEITIPKGAESGFHVTRIRAIDRDSGVNAELSCAIVAGNEENIFIIDPRSCDIHTNVSMDSVPYTEWELSVIIQDKGNPQLHTKVLLKCMIFEYAESVTSTAMTSVSQASLDVSMIIIISLGAICAVLLVIMVLFATRCNREKKDTRSYNCRVAESTYQHHPKRPSRQIHKGDITLVPTINGTLPIRSHHRSSPSSSPTLERGQMGSRQSHNSHQSLNSLVTISSNHVPENFSLELTHATPAVEQVSQLLSMLHQGQYQPRPSFRGNKYSRSYRYALQDMDKFSLKDSGRGDSEAGDSDYDLGRDSPIDRLLGEGFSDLFLTDGRIPAAMRLCTEECRVLGHSDQCWMPPLPSPSSDYRSNMFIPGEEFPTQPQQQHPHQSLEDDAQPADSGEKKKSFSTFGKDSPNDEDTGDTSTSSLLSEMSSVFQRLLPPSLDTYSECSEVDRSNSLERRKGPLPAKTVGYPQGVAAWAASTHFQNPTTNCGPPLGTHSSVQPSSKWLPAMEEIPENYEEDDFDNVLNHLNDGKHELMDASELVAEINKLLQDVRQS

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9HCL0-1; Sequence=Displayed; Name=2; IsoId=Q9HCL0-2; Sequence=VSP_035648

Alternative Sequence

830; Missing (in isoform 2)

3D Structural Models

Turn

81..83; 206..208; 301..303; 314..316; 425..427

Helix

47..50; 52..55; 61..63; 94..98; 167..169; 276..279; 291..296; 390..393

Beta Strand

29..35; 43..46; 58..60; 65..69; 76..79; 85..88; 105..115; 120..128; 140..147; 155..157; 170..176; 180..188; 194..200; 211..220; 227..237; 245..247; 249..256; 264..267; 281..285; 297..299; 305..310; 319..330; 336..345; 353..357; 380..385; 395..399; 405..411; 414..419; 430..440; 446..454

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

791..800; Polar residues; 869..878; Basic and acidic residues; 1028..1039; Basic and acidic residues

Domain (FT)

28..137; Cadherin 1; 138..246; Cadherin 2; 247..354; Cadherin 3; 361..465; Cadherin 4; 466..576; Cadherin 5; 582..688; Cadherin 6

Region

769..800; Disordered; 869..889; Disordered; 893..1135; Interaction with DAB1; 942..1003; Disordered; 1023..1046; Disordered

Clinical Relevance1

Antibody

HPA017976

Supporting Publications6

PMID	Title	Abstract
33592500	A Proteomic Approach to Understand the Clinical Significance of Acute Myeloid Leukemia-Derived Extracellular Vesicles Reflecting Essential Characteristics of Leukemia.	No abstract available
37322475	Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration.	No abstract available
38113368	In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.	No abstract available
38607062	Enrichment, Characterization, and Proteomic Profiling of Small Extracellular Vesicles Derived from Human Limbal Mesenchymal Stromal Cells and Melanocytes.	No abstract available
41068253	Identification of plasma extracellular vesicle protein biomarkers in diabetic retinopathy progression.	No abstract available
41307968	Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System.	No abstract available