Protein detail
GPVI
Platelet glycoprotein VI (GPVI) (Glycoprotein 6)
Protein symbol GPVI | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Platelet glycoprotein VI (GPVI) (Glycoprotein 6)
Protein Class
Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Predicted intracellular proteins
Transmembrane
268..288; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
GPVI
Gene Description
Glycoprotein VI platelet
Chromosome
19
Position
55013705-55038264
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificheart muscleCell SpecificCardiomyocytesSingle-Nuclei Brain Specificpericyte
Function & Pathway
Protein Function
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
31 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | GO_Intercell | No | Yes | No | Yes | No |
| receptor | receptor | CellChatDB | No | Yes | No | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| matrix_adhesion | adhesion | OmniPath | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| A0A678ZGP6 | A0A678ZGP6 | 16 | PDB | PDB:7stgPDB:7sshPDB:7st3 | ||
| COL1A1GP6 | P02452Q9HCN6 | 3:2 | PDB | PDB:5ou8PDB:5ou9 | ||
| GP6 | Q9HCN6 | 2 | PDB | PDB:2gi7PDB:7nmuPDB:5ou7 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 35029059 |
Sequence, Structure & Domains
Sequences
Length
339
Mass
36,866
Sequence
MSPSPTALFCLGLCLGRVPAQSGPLPKPSLQALPSSLVPLEKPVTLRCQGPPGVDLYRLEKLSSSRYQDQAVLFIPAMKRSLAGRYRCSYQNGSLWSLPSDQLELVATGVFAKPSLSAQPGPAVSSGGDVTLQCQTRYGFDQFALYKEGDPAPYKNPERWYRASFPIITVTAAHSGTYRCYSFSSRDPYLWSAPSDPLELVVTGTSVTPSRLPTEPPSPVAEFSEATAELTVSFTNEVFTTETSRSITASPKESDSPAGPARQYYTKGNLVRICLGAVILIILAGFLAEDWHSRRKRLRHRGRAVQRPLPPLPPLPLTRKSNGGQDGGRQDVHSRGLCS
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=VI-1; IsoId=Q9HCN6-1; Sequence=Displayed; Name=2; Synonyms=VI-2; IsoId=Q9HCN6-2; Sequence=VSP_017879; Name=3; Synonyms=VI-3; IsoId=Q9HCN6-3; Sequence=VSP_017880
Alternative Sequence
204..221; Missing (in isoform 2); 260..339; PARQYYTKGNLVRICLGAVILIILAGFLAEDWHSRRKRLRHRGRAVQRPLPPLPPLPLTRKSNGGQDGGRQDVHSRGLCS -> ESCPPVLHQGQPGPDMPRGCDPNNPGGVSGRGLAQPEEAPAAQGQGCAEAASAPPAPPADPEIKRGSGWRPTGCSQPRVMFMTAEPQARSYPREGSWHGRRLKDWRVWSVEAGGQRLQLWKRGHAASSWCSIREPFGQCLSVCLPLCLRAPSIWDGRNLWRPHPPPCTLWMTWYPGWTTYWPLSSTSLIWAPDGSLRFPALRVDSVPSSVQNPPVLPFGPLCSCLVFPRNSHPHSISHCGLTNLLSSLRTGLAGSLGMSFIFLSVKLARCPLPFTLENKISLCNMVKPHLYQQNKKTQKLARCGGASLYSQQLRGLRWENGLSLGGRGCSELRSHHCTLARVTKPDFVSKNTGMNMSITLI (in isoform 3)
3D Structural Models
Turn
62..65; 126..128
Helix
80..82; 172..174
Beta Strand
29..34; 36..39; 44..49; 55..61; 66..77; 84..92; 95..97; 103..111; 115..120; 122..125; 130..135; 142..147; 149..151; 159..170; 175..184; 187..192; 198..201
3D Structure
X-ray crystallography (6)
Domain & Motif Annotations
Compositional Bias
328..339; Basic and acidic residues
Domain (FT)
26..104; Ig-like C2-type 1; 114..196; Ig-like C2-type 2
Region
299..339; Disordered
Clinical Relevance
Disease Involvement
Disease variant
Related Diseases
Biomarker
Phase 2; Phase 1/2
Drug Targets
Clinical trial target
Drugs
Interaction Protein
ENSG00000254087
Interaction Count
1
Interaction Dataset
intact_biogrid