Protein detail
GPVI
Platelet glycoprotein VI (GPVI) (Glycoprotein 6)
Entry name GPVI | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Platelet glycoprotein VI (GPVI) (Glycoprotein 6)
Protein Class (5)
Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function (3)
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Predicted intracellular proteins
Transmembrane
268..288; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
GPVI
Gene Description
Glycoprotein VI platelet
Chromosome
19
Position
55013705-55038264
Supporting publications (n)
1
EVMP confidence score
0.53
Fluorescence & Localization
Tissue Specificheart muscleCell SpecificCardiomyocytesSingle-Nuclei Brain Specificpericyte
Function & Pathway
Protein Function (3)
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Predicted intracellular proteins
Cellular Component (5)
Molecular Function (6)
Biological Process (3)
Reactome (5)
Mediation Categories (5)
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence35
Ligand-Receptor Signaling (31)
31 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | GO_Intercell | Yes | Yes | |||
| receptor | receptor | CellChatDB | Yes | Yes | |||
| receptor | receptor | CellTalkDB | Yes | Yes | |||
| receptor | receptor | OmniPath | Yes | Yes | |||
| extracellular | extracellular | OmniPath | Yes | ||||
| intracellular | intracellular | ComPPI | Yes | ||||
| intracellular | intracellular | OmniPath | Yes | ||||
| matrix_adhesion | adhesion | OmniPath | Yes | Yes | Yes | ||
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | Yes | ||
| adhesion | adhesion | OmniPath | Yes | Yes | Yes |
Page 1 of 4Next
Protein Complex Composition (3)
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| A0A678ZGP6 | A0A678ZGP6 | 16 | PDB | PDB:7stgPDB:7sshPDB:7st3 | ||
| COL1A1GP6 | P02452Q9HCN6 | 3:2 | PDB | PDB:5ou8PDB:5ou9 | ||
| GP6 | Q9HCN6 | 2 | PDB | PDB:2gi7PDB:7nmuPDB:5ou7 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 35029059 |
Sequence, Structure & Domains
Sequences
Length
339
Mass
36,866
Sequence
MSPSPTALFCLGLCLGRVPAQSGPLPKPSLQALPSSLVPLEKPVTLRCQGPPGVDLYRLEKLSSSRYQDQAVLFIPAMKRSLAGRYRCSYQNGSLWSLPSDQLELVATGVFAKPSLSAQPGPAVSSGGDVTLQCQTRYGFDQFALYKEGDPAPYKNPERWYRASFPIITVTAAHSGTYRCYSFSSRDPYLWSAPSDPLELVVTGTSVTPSRLPTEPPSPVAEFSEATAELTVSFTNEVFTTETSRSITASPKESDSPAGPARQYYTKGNLVRICLGAVILIILAGFLAEDWHSRRKRLRHRGRAVQRPLPPLPPLPLTRKSNGGQDGGRQDVHSRGLCS
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=VI-1; IsoId=Q9HCN6-1; Sequence=Displayed; Name=2; Synonyms=VI-2; IsoId=Q9HCN6-2; Sequence=VSP_017879; Name=3; Synonyms=VI-3; IsoId=Q9HCN6-3; Sequence=VSP_017880
Alternative Sequence
204..221; Missing (in isoform 2); 260..339; PARQYYTKGNLVRICLGAVILIILAGFLAEDWHSRRKRLRHRGRAVQRPLPPLPPLPLTRKSNGGQDGGRQDVHSRGLCS -> ESCPPVLHQGQPGPDMPRGCDPNNPGGVSGRGLAQPEEAPAAQGQGCAEAASAPPAPPADPEIKRGSGWRPTGCSQPRVMFMTAEPQARSYPREGSWHGRRLKDWRVWSVEAGGQRLQLWKRGHAASSWCSIREPFGQCLSVCLPLCLRAPSIWDGRNLWRPHPPPCTLWMTWYPGWTTYWPLSSTSLIWAPDGSLRFPALRVDSVPSSVQNPPVLPFGPLCSCLVFPRNSHPHSISHCGLTNLLSSLRTGLAGSLGMSFIFLSVKLARCPLPFTLENKISLCNMVKPHLYQQNKKTQKLARCGGASLYSQQLRGLRWENGLSLGGRGCSELRSHHCTLARVTKPDFVSKNTGMNMSITLI (in isoform 3)
3D Structural Models
Turn
62..65; 126..128
Helix
80..82; 172..174
Beta Strand
29..34; 36..39; 44..49; 55..61; 66..77; 84..92; 95..97; 103..111; 115..120; 122..125; 130..135; 142..147; 149..151; 159..170; 175..184; 187..192; 198..201
3D Structure
X-ray crystallography (6)
Domain & Motif Annotations
Compositional Bias
328..339; Basic and acidic residues
Domain (FT)
26..104; Ig-like C2-type 1; 114..196; Ig-like C2-type 2
Region
299..339; Disordered
Clinical Relevance
Disease Involvement
Disease variant
Related Diseases (2)
Biomarker
Phase 2; Phase 1/2
Drug Targets
Clinical trial target
Drugs (2)
Interaction Protein
ENSG00000254087
Interaction Count
1
Interaction Dataset
intact_biogrid
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 37714423 | Exosomes and their miRNA/protein profile in keratoconus-derived corneal stromal cells. | No related sentences available |