Protein detail
CD248
Endosialin (Tumor endothelial marker 1) (CD antigen CD248)
Entry name CD248 | UniProt ID | EVMP confidence score 0.72 |
Supporting publications (n) 11 | Transmembrane count 1 | Protein classification CD markersPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Endosialin (Tumor endothelial marker 1) (CD antigen CD248)
Protein Class (2)
CD markersPredicted membrane proteins
Protein Function
CD markers
Transmembrane
688..708; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
CD164L1TEM1
Gene Description
CD248 molecule
Chromosome
11
Position
66314494-66317044
Supporting publications (n)
11
EVMP confidence score
0.72
Fluorescence & Localization5
Tissue SpecifictestisCell SpecificEarly spermatidsBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes
Function & Pathway5
Protein Function
CD markers
Cellular Component (4)
Molecular Function (6)
Biological Process (3)
Mediation Categories (2)
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence44
Ligand-Receptor Signaling (43)
43 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | MatrixDB | Yes | No | No | Yes | No |
| ecm | ecm | CellCellInteractions | Yes | No | No | Yes | No |
| ecm | ecm | OmniPath | Yes | No | No | Yes | No |
| extracellular | extracellular | HPMR | No | No | No | Yes | No |
| extracellular | extracellular | DGIdb | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | CellPhoneDB | Yes | No | No | Yes | No |
Isolation & Detection Technology (1)
Sequence, Structure & Domains8
Sequences
Length
757
Mass
80,859
Sequence
MLLRLLLAWAAAGPTLGQDPWAAEPRAACGPSSCYALFPRRRTFLEAWRACRELGGDLATPRTPEEAQRVDSLVGAGPASRLLWIGLQRQARQCQLQRPLRGFTWTTGDQDTAFTNWAQPASGGPCPAQRCVALEASGEHRWLEGSCTLAVDGYLCQFGFEGACPALQDEAGQAGPAVYTTPFHLVSTEFEWLPFGSVAAVQCQAGRGASLLCVKQPEGGVGWSRAGPLCLGTGCSPDNGGCEHECVEEVDGHVSCRCTEGFRLAADGRSCEDPCAQAPCEQQCEPGGPQGYSCHCRLGFRPAEDDPHRCVDTDECQIAGVCQQMCVNYVGGFECYCSEGHELEADGISCSPAGAMGAQASQDLGDELLDDGEDEEDEDEAWKAFNGGWTEMPGILWMEPTQPPDFALAYRPSFPEDREPQIPYPEPTWPPPLSAPRVPYHSSVLSVTRPVVVSATHPTLPSAHQPPVIPATHPALSRDHQIPVIAANYPDLPSAYQPGILSVSHSAQPPAHQPPMISTKYPELFPAHQSPMFPDTRVAGTQTTTHLPGIPPNHAPLVTTLGAQLPPQAPDALVLRTQATQLPIIPTAQPSLTTTSRSPVSPAHQISVPAATQPAALPTLLPSQSPTNQTSPISPTHPHSKAPQIPREDGPSPKLALWLPSPAPTAAPTALGEAGLAEHSQRDDRWLLVALLVPTCVFLVVLLALGIVYCTRCGPHAPNKRITDCYRWVIHAGSKSPTEPMPPRGSLTGVQTCRTSV
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9HCU0-1; Sequence=Displayed; Name=2; IsoId=Q9HCU0-2; Sequence=VSP_017087
Alternative Sequence
1..324; Missing (in isoform 2)
Domain & Motif Annotations
Compositional Bias
618..627; Low complexity; 748..757; Polar residues
Domain (FT)
30..156; C-type lectin; 162..232; Sushi; 312..351; EGF-like; calcium-binding
Region
618..662; Disordered; 737..757; Disordered
Clinical Relevance4
Related Diseases (5)
Biomarker
Phase 2
Drugs (2)
Antibody
Supporting Publications11
| PMID | Title | Abstract |
|---|---|---|
| 23161513 | Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS. | Exosomes from mutant KRAS cells contain many tumor-promoting proteins, including KRAS, EGFR, SRC family kinases, and integrins. |
| 30608700 | Quantitative Proteomic Analysis of Small and Large Extracellular Vesicles (EVs) Reveals Enrichment of Adhesion Proteins in Small EVs. | No abstract available |
| 32795414 | Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. | Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers. |
| 34889606 | Surface Nanosieving Polyether Sulfone Particles with Graphene Oxide Encapsulation for the Negative Isolation toward Extracellular Vesicles. | No abstract available |
| 37686366 | Identification of a Non-Invasive Urinary Exosomal Biomarker for Diabetic Nephropathy Using Data-Independent Acquisition Proteomics. | No abstract available |
| 37926697 | Analysis of small EV proteomes reveals unique functional protein networks regulated by VAP-A. | No abstract available |
| 38698420 | Single-sEV profiling identifies the TACSTD2 + sEV subpopulation as a factor of tumor susceptibility in the elderly. | No abstract available |
| 39940785 | Secretome and Proteome of Extracellular Vesicles Provide Protein Markers of Lung and Colorectal Cancer. | No abstract available |
| 40098346 | Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays. | No abstract available |
| 40311616 | Integrative proteomic profiling of tumor and plasma extracellular vesicles identifies a diagnostic biomarker panel for colorectal cancer. | No abstract available |
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