Protein detail
PTPRH
Receptor-type tyrosine-protein phosphatase H (R-PTP-H) (EC 3.1.3.48) (Stomach cancer-associated protein tyrosine phosphatase 1) (SAP-1) (Transmembrane-type protein-tyrosine phosphatase type H)
Entry name PTPRH | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 3 | Transmembrane count 1 | Protein classification |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Receptor-type tyrosine-protein phosphatase H (R-PTP-H) (EC 3.1.3.48) (Stomach cancer-associated protein tyrosine phosphatase 1) (SAP-1) (Transmembrane-type protein-tyrosine phosphatase type H)
Protein Function (2)
- Enzymes
- ENZYME proteins:Hydrolases
Transmembrane
755..775; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Supporting publications (n)
3
EVMP confidence score
0.40
Fluorescence & Localization
Tissue SpecificliverCell SpecificHepatocytesSingle-Nuclei Brain Specificchoroid plexus epithelial cell
Function & Pathway
Protein Function (2)
- Enzymes
- ENZYME proteins:Hydrolases
Cellular Component (5)
Molecular Function (4)
Biological Process (3)
Mediation Categories (2)
Fusion and delivery mediationMetabolism mediation
Relations & Evidence45
Ligand-Receptor Signaling (41)
41 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane_tmhmm | transmembrane_predicted | Almen2009 | Yes |
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Regulatory Interaction Network (3)
3 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PTPRH | Q9HD43 | INSR | P06213 | Yes | Yes | SIGNOR_ProtMapperSIGNORProtMapper | ProtMapper:10734133SIGNOR:10734133 | |
| PTPRH | Q9HD43 | EGFR | P00533 | Yes | Yes | SIGNOR | SIGNOR:28065597 | |
| PTPRH | Q9HD43 | GHR | P10912 | Yes | Yes | Lit-BM-17SIGNORIntAct | Lit-BM-17:12907755IntAct:12907755SIGNOR:12907755 |
Sequence, Structure & Domains
Sequences
Length
1,115
Mass
122,353
Sequence
MAGAGGGLGVWGNLVLLGLCSWTGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATNVTVDGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAPNPVRNLRVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDGLEPGCLYAFSMWVGKNGINSSRETRNATTAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRTETRNTTDTRVTVDGLGPGSLYTCSVWVEKDGVNSSVEIVTSATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEAFELEVGGQRGSQDRSSCGEAVSVLGLGPARSYPATITTIWDGMKVVSHSVVCHTESAGVIAGAFVGILLFLILVGLLIFFLKRRNKKKQQKPELRDLVFSSPGDIPAEDFADHVRKNERDSNCGFADEYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQAPAEKEVPYEDVENLIYENVAAIQAHKLEV
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9HD43-1; Sequence=Displayed; Name=2; IsoId=Q9HD43-2; Sequence=VSP_031318; Name=3; IsoId=Q9HD43-3; Sequence=VSP_054222
Alternative Sequence
84..261; Missing (in isoform 2); 126..303; Missing (in isoform 3)
3D Structural Models
Turn
828..833; 837..840; 857..859; 870..873; 968..971
Helix
802..804; 805..827; 842..847; 897..899; 900..910; 993..1007; 1025..1043; 1048..1058; 1066..1082
Beta Strand
876..880; 888..892; 914..917; 921..923; 940..942; 945..954; 956..967; 972..981; 1012..1014; 1017..1019; 1021..1024; 1044..1046
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Domain (CC)
The extracellular domain mediates homodimerization. One or more cysteines in the extracellular domain is essential for the formation of dimers probably by forming a disulfide bond.; DOMAIN: The cytoplasmic domain mediates the interaction with LCK.
Domain (FT)
32..121; Fibronectin type-III 1; 122..209; Fibronectin type-III 2; 210..299; Fibronectin type-III 3; 300..387; Fibronectin type-III 4; 388..477; Fibronectin type-III 5; 478..563; Fibronectin type-III 6; 564..666; Fibronectin type-III 7; 665..749; Fibronectin type-III 8; 820..1079; Tyrosine-protein phosphatase
Protein Families (2)
- Protein-tyrosine phosphatase family
- Receptor class 3 subfamily
Sequence Similarities
Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.
Clinical Relevance
Interaction Protein (2)
ENSG00000112964ENSG00000146648
Interaction Count
2
Interaction Dataset
intact_biogrid
Supporting Publications3
| PMID | Title | Related sentences |
|---|---|---|
| 36982312 | Saliva and Saliva Extracellular Vesicles for Biomarker Candidate Identification-Assay Development and Pilot Study in Amyotrophic Lateral Sclerosis. | No related sentences available |
| 37322475 | Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration. | No related sentences available |
| 38207106 | Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity. | No related sentences available |