Protein detail

S40A1

Ferroportin (Ferroportin-1) (Iron-regulated transporter 1) (Solute carrier family 40 member 1)

Entry name S40A1	UniProt ID Q9NP59	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 12	Protein classification Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Ferroportin (Ferroportin-1) (Iron-regulated transporter 1) (Solute carrier family 40 member 1)

Protein Class (7)

Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function (5)

Predicted intracellular proteins
Human disease related genes:Congenital disorders of metabolism:Congenital disorders of ion transport and metabolism
Potential drug targets
Transporters:Electrochemical Potential-driven transporters
Disease related genes

Transmembrane

24..53; Helical; 58..84; Helical; 88..118; Helical; 127..162; Helical; 165..195; Helical; 203..229; Helical; 307..333; Helical; 339..366; Helical; 369..391; Helical; 454..483; Helical; 489..513; Helical; 517..542; Helical

Transmembrane Count

Ensembl

ENSG00000138449

Entrez Gene Symbol

SLC40A1

Gene Synonym (5)

FPN1HFE4IREG1MTP1SLC11A3

Gene Description

Solute carrier family 40 member 1

Chromosome

Position

189560590-189583758

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Tissue SpecificbrainCell SpecificBrain excitatory neuronsSingle-Nuclei Brain Specificmammillary body

Function & Pathway7

Protein Function (5)

Predicted intracellular proteins
Human disease related genes:Congenital disorders of metabolism:Congenital disorders of ion transport and metabolism
Potential drug targets
Transporters:Electrochemical Potential-driven transporters
Disease related genes

Cellular Component (7)

Molecular Function (6)

Biological Process (3)

KEGG (3)

Reactome (6)

Mediation Categories (4)

Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediation

Relations & Evidence26

Ligand-Receptor Signaling (24)

24 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
cell_surface	cell_surface	Surfaceome	No	No	No	No	No
cell_surface	cell_surface	connectomeDB2020	No	No	No	No	No
cell_surface	cell_surface	OmniPath	No	No	No	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	HAMP SLC40A1	P81172 Q9NP59	1:1	PDB	PDB:6wbv

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometrySmall R sequencing (Illumi HiSeq 2000 (Solexa)	41	40189497 37926756 40831280 40985879 36064647 38113368 40465195 36736734 35119778 37322475 33304478 36497184 25755179 34064677 26826536 31382537 41068253 33592500 32854315 38014595 34473505 38891077 30915084 32560723 31617158 41307968 36146834 33309826 27821849 40840701 37670049 31805958 33893753 38607062 38207106 38716512 32835735 34576246 37204515 39001700 39207047

Sequence, Structure & Domains9

Sequences

Length

571

Mass

62,542

Sequence

MTRAGDHNRQRGCCGSLADYLTSAKFLLYLGHSLSTWGDRMWHFAVSVFLVELYGNSLLLTAVYGLVVAGSVLVLGAIIGDWVDKNARLKVAQTSLVVQNVSVILCGIILMMVFLHKHELLTMYHGWVLTSCYILIITIANIANLASTATAITIQRDWIVVVAGEDRSKLANMNATIRRIDQLTNILAPMAVGQIMTFGSPVIGCGFISGWNLVSMCVEYVLLWKVYQKTPALAVKAGLKEEETELKQLNLHKDTEPKPLEGTHLMGVKDSNIHELEHEQEPTCASQMAEPFRTFRDGWVSYYNQPVFLAGMGLAFLYMTVLGFDCITTGYAYTQGLSGSILSILMGASAITGIMGTVAFTWLRRKCGLVRTGLISGLAQLSCLILCVISVFMPGSPLDLSVSPFEDIRSRFIQGESITPTKIPEITTEIYMSNGSNSANIVPETSPESVPIISVSLLFAGVIAARIGLWSFDLTVTQLLQENVIESERGIINGVQNSMNYLLDLLHFIMVILAPNPEAFGLLVLISVSFVAMGHIMYFRFAQNTLGNKLFACGPDAKEVRKENQANTSVV

3D Structural Models

Turn

54..56; 163..165; 324..327

Helix

17..20; 24..53; 59..85; 88..115; 117..122; 126..155; 158..162; 167..198; 201..229; 231..234; 290..303; 308..316; 328..334; 339..366; 369..390; 453..483; 486..488; 489..513; 517..545

Beta Strand

321..323; 393..395; 400..402

3D Structure

Electron microscopy (8)

Domain & Motif Annotations

Protein Families (2)

Ferroportin (FP) (TC 2.A.100) family
SLC40A subfamily

Sequence Similarities

Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.

Clinical Relevance6

Disease Involvement

Disease variant

Related Diseases (5)

Acute disease anaemia Anemia Myelodysplastic syndrome Myeloproliferative neoplasm Thalassaemia

Biomarker

Phase 2; Phase 1

Drug Targets

Clinical trial target

Drugs

LY2928057

Antibody

HPA065634

Supporting Publications1

PMID	Title	Abstract
37087495	Siglec-6 mediates the uptake of extracellular vesicles through a noncanonical glycolipid binding pocket.	No abstract available