Protein detail
IRPL2
X-linked interleukin-1 receptor accessory protein-like 2 (IL-1 receptor accessory protein-like 2) (IL-1-RAPL-2) (IL-1RAPL-2) (IL1RAPL-2) (EC 3.2.2.6) (IL1RAPL-2-related protein) (Interleukin-1 receptor 9) (IL-1R-9) (IL-1R9) (Three immunoglobulin domain-containing IL-1 receptor-related 1) (TIGIRR-1)
Protein symbol IRPL2 | UniProt ID | EVMP score 0.50 |
Frequency 4 | Transmembrane count 1 | Protein classification |
Basic Information
Protein Names
X-linked interleukin-1 receptor accessory protein-like 2 (IL-1 receptor accessory protein-like 2) (IL-1-RAPL-2) (IL-1RAPL-2) (IL1RAPL-2) (EC 3.2.2.6) (IL1RAPL-2-related protein) (Interleukin-1 receptor 9) (IL-1R-9) (IL-1R9) (Three immunoglobulin domain-containing IL-1 receptor-related 1) (TIGIRR-1)
Protein Function
- Enzymes
- ENZYME proteins:Hydrolases
Transmembrane
355..375; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Frequency
4
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificliverCell SpecificEndometrial luminal cellsSingle-Nuclei Brain Specificendothelial cell
Function & Pathway
Protein Function
- Enzymes
- ENZYME proteins:Hydrolases
Molecular Function
Biological Process
Reactome
Mediation Categories
Other mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
50 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ig | receptor | Surfaceome | No | Yes | No | Yes | No |
| type1 | receptor | Surfaceome | No | Yes | No | Yes | No |
| cytokiner | receptor | Surfaceome | No | Yes | No | Yes | No |
| cytokine | receptor | ICELLNET | No | Yes | No | Yes | No |
| cytokine_il1_family | receptor | ICELLNET | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| extracellular | extracellular | HPMR | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | Yes | No |
Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| IRPL2 | Q9NP60 | NCS1 | P62166 | Yes | Yes | No | SIGNOR | SIGNOR:12783849 |
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
686
Mass
78,670
Sequence
MKPPFLLALVVCSVVSTNLKMVSKRNSVDGCIDWSVDLKTYMALAGEPVRVKCALFYSYIRTNYSTAQSTGLRLMWYKNKGDLEEPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQEPDVVWYKECKPKMWRSIIIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHASVLLRKKDLIYKIELAGGLGAIFLLLVLLVVIYKCYNIELMLFYRQHFGADETNDDNKEYDAYLSYTKVDQDTLDCDNPEEEQFALEVLPDVLEKHYGYKLFIPERDLIPSGTYMEDLTRYVEQSRRLIIVLTPDYILRRGWSIFELESRLHNMLVSGEIKVILIECTELKGKVNCQEVESLKRSIKLLSLIKWKGSKSSKLNSKFWKHLVYEMPIKKKEMLPRCHVLDSAEQGLFGELQPIPSIAMTSTSATLVSSQADLPEFHPSDSMQIRHCCRGYKHEIPATTLPVPSLGNHHTYCNLPLTLLNGQLPLNNTLKDTQEFHRNSSLLPLSSKELSFTSDIW
3D Structural Models
Turn
482..484
Helix
421..428; 430..436; 446..449; 456..465; 476..481; 485..489; 491..498; 515..526; 539..542; 547..555
Beta Strand
402..407; 467..474; 501..508; 529..535; 543..545
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Domain (CC)
The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.
Domain (FT)
18..132; Ig-like C2-type 1; 141..232; Ig-like C2-type 2; 239..347; Ig-like C2-type 3; 400..556; TIR
Protein Families
Interleukin-1 receptor family
Sequence Similarities
Belongs to the interleukin-1 receptor family.