Protein detail

IRPL2

X-linked interleukin-1 receptor accessory protein-like 2 (IL-1 receptor accessory protein-like 2) (IL-1-RAPL-2) (IL-1RAPL-2) (IL1RAPL-2) (EC 3.2.2.6) (IL1RAPL-2-related protein) (Interleukin-1 receptor 9) (IL-1R-9) (IL-1R9) (Three immunoglobulin domain-containing IL-1 receptor-related 1) (TIGIRR-1)

Entry name IRPL2	UniProt ID Q9NP60	EVMP confidence score 0.50
Supporting publications (n) 4	Transmembrane count 1	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Protein Function (2)

Enzymes
ENZYME proteins:Hydrolases

Transmembrane

355..375; Helical

Transmembrane Count

Ensembl

ENSG00000189108

Entrez Gene Symbol

IL1RAPL2

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Tissue SpecificliverCell SpecificEndometrial luminal cellsSingle-Nuclei Brain Specificendothelial cell

Function & Pathway7

Protein Function (2)

Enzymes
ENZYME proteins:Hydrolases

Cellular Component (3)

Molecular Function (4)

Biological Process (3)

KEGG

hsa04517 IgSF CAM signaling

Reactome (3)

Mediation Categories

Other mediation

Relations & Evidence52

Ligand-Receptor Signaling (50)

50 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ligand	ligand	OmniPath	Yes	No	No	Yes	No
receptor	receptor	Cellinker	No	Yes	No	Yes	No
receptor	receptor	Almen2009	No	Yes	No	Yes	No
receptor	receptor	CellCellInteractions	No	Yes	No	Yes	No
interleukin	receptor	HGNC	No	Yes	No	Yes	No
tir_domain	receptor	HGNC	No	Yes	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No
transmembrane_phobius	transmembrane_predicted	Almen2009	No	No	No	Yes	No
transmembrane_sosui	transmembrane_predicted	Almen2009	No	No	No	Yes	No
transmembrane_tmhmm	transmembrane_predicted	Almen2009	No	No	No	Yes	No

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Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
IRPL2	Q9NP60	NCS1	P62166	Yes	Yes	No	SIGNOR	SIGNOR:12783849

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometryWestern blotting	4	38225453 38731868 33580265 38164498

Sequence, Structure & Domains11

Sequences

Length

686

Mass

78,670

Sequence

MKPPFLLALVVCSVVSTNLKMVSKRNSVDGCIDWSVDLKTYMALAGEPVRVKCALFYSYIRTNYSTAQSTGLRLMWYKNKGDLEEPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQEPDVVWYKECKPKMWRSIIIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHASVLLRKKDLIYKIELAGGLGAIFLLLVLLVVIYKCYNIELMLFYRQHFGADETNDDNKEYDAYLSYTKVDQDTLDCDNPEEEQFALEVLPDVLEKHYGYKLFIPERDLIPSGTYMEDLTRYVEQSRRLIIVLTPDYILRRGWSIFELESRLHNMLVSGEIKVILIECTELKGKVNCQEVESLKRSIKLLSLIKWKGSKSSKLNSKFWKHLVYEMPIKKKEMLPRCHVLDSAEQGLFGELQPIPSIAMTSTSATLVSSQADLPEFHPSDSMQIRHCCRGYKHEIPATTLPVPSLGNHHTYCNLPLTLLNGQLPLNNTLKDTQEFHRNSSLLPLSSKELSFTSDIW

3D Structural Models

Turn

482..484

Helix

421..428; 430..436; 446..449; 456..465; 476..481; 485..489; 491..498; 515..526; 539..542; 547..555

Beta Strand

402..407; 467..474; 501..508; 529..535; 543..545

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Domain (CC)

The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.

Domain (FT)

18..132; Ig-like C2-type 1; 141..232; Ig-like C2-type 2; 239..347; Ig-like C2-type 3; 400..556; TIR

Protein Families

Interleukin-1 receptor family

Sequence Similarities

Belongs to the interleukin-1 receptor family.

Supporting Publications4

PMID	Title	Abstract
24505114	Proteomics analysis of cancer exosomes using a novel modified aptamer-based array (SOMAscan™) platform.	These included proteins of known association with cancer exosomes such as MFG-E8, integrins, and MET, and also those less widely reported as exosomally associated, such as ROR1 and ITIH4.
31588238	Dual-platform affinity proteomics identifies links between the recurrence of ovarian carcinoma and proteins released into the tumor microenvironment.	No abstract available
37686366	Identification of a Non-Invasive Urinary Exosomal Biomarker for Diabetic Nephropathy Using Data-Independent Acquisition Proteomics.	No abstract available
40098346	Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.	No abstract available