Protein detail
TNR12
Tumor necrosis factor receptor superfamily member 12A (Fibroblast growth factor-inducible immediate-early response protein 14) (FGF-inducible 14) (Tweak-receptor) (TweakR) (CD antigen CD266)
Entry name TNR12 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification Cancer-related genesCD markersPredicted intracellular proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Tumor necrosis factor receptor superfamily member 12A (Fibroblast growth factor-inducible immediate-early response protein 14) (FGF-inducible 14) (Tweak-receptor) (TweakR) (CD antigen CD266)
Protein Class
Cancer-related genesCD markersPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Cancer-related genes:Candidate cancer biomarkers
- CD markers
- Predicted intracellular proteins
Transmembrane
81..101; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CD266FN14TweakR
Gene Description
TNF receptor superfamily member 12A
Chromosome
16
Position
3018445-3022383
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificbrainCell SpecificAstrocytes
Function & Pathway
Protein Function
- Cancer-related genes:Candidate cancer biomarkers
- CD markers
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Canonical Pathways
- M92 Pid angiopoietin receptor pathway
- M100 Pid shp2 pathway
Mediation Categories
Clinical-translation mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
49 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| tnf_receptor | receptor | CellPhoneDB | No | Yes | No | Yes | No |
| cytokine | receptor | Baccin2019 | No | Yes | No | Yes | No |
| tnf_ngf | receptor | HPMR | No | Yes | No | Yes | No |
| trail_tnf_ngf | receptor | HPMR | No | Yes | No | Yes | No |
| cytokine | receptor | ICELLNET | No | Yes | No | Yes | No |
| cytokine_tnf | receptor | ICELLNET | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| extracellular | extracellular | HPMR | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 15326289 |
Sequence, Structure & Domains
Sequences
Length
129
Mass
13,911
Sequence
MARGSLRRLLRLLVLGLWLALLRSVAGEQAPGTAPCSRGSSWSADLDKCMDCASCRARPHSDFCLGCAAAPPAPFRLLWPILGGALSLTFVLGLLSGFLVWRRCRRREKFTTPIEETGGEGCPAVALIQ
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NP84-1; Sequence=Displayed; Name=2; IsoId=Q9NP84-2; Sequence=VSP_006519
Alternative Sequence
33..67; Missing (in isoform 2)
3D Structural Models
Turn
44..47
Helix
30..33; 52..57; 62..65
Beta Strand
41..43; 48..50
3D Structure
NMR spectroscopy (3)
Domain & Motif Annotations
Repeat
36..67; TNFR-Cys; atypical
Clinical Relevance
Disease Involvement
Cancer-related genes
Related Diseases
Biomarker
Phase 1
Drugs
Antibody
Interaction Protein
ENSG00000127191
Interaction Count
1
Interaction Dataset
intact_biogrid