Protein detail
S39A2
Zinc transporter ZIP2 (6A1) (Eti-1) (Solute carrier family 39 member 2) (Zrt- and Irt-like protein 2) (ZIP-2) (hZIP2)
Entry name S39A2 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 8 | Protein classification Metabolic proteinsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Zinc transporter ZIP2 (6A1) (Eti-1) (Solute carrier family 39 member 2) (Zrt- and Irt-like protein 2) (ZIP-2) (hZIP2)
Protein Class (3)
Metabolic proteinsPredicted membrane proteinsTransporters
Protein Function
Transporters:Electrochemical Potential-driven transporters
Transmembrane
9..29; Helical; 47..67; Helical; 104..124; Helical; 165..185; Helical; 190..210; Helical; 225..245; Helical; 259..279; Helical; 289..309; Helical
Transmembrane Count
8
Ensembl
Entrez Gene Symbol
Gene Synonym
ZIP2
Gene Description
Solute carrier family 39 member 2
Chromosome
14
Position
20999255-21001871
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization7
Tissue SpecificintestineCell SpecificColonocytesSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificNK-cellBlood Lineage SpecificNK-cellsSecretome LocationIntracellular and membraneSecretome FunctionReceptor
Function & Pathway7
Protein Function
Transporters:Electrochemical Potential-driven transporters
Cellular Component (3)
Molecular Function (3)
Biological Process (3)
Reactome (5)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence21
Ligand-Receptor Signaling (20)
20 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | LOCATE | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | No | No |
| cell_surface | cell_surface | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Flow CytometryElisa | 1 | 37298418 |
Sequence, Structure & Domains7
Sequences
Length
309
Mass
32,742
Sequence
MEQLLGIKLGCLFALLALTLGCGLTPICFKWFQIDAARGHHRLVLRLLGCISAGVFLGAGFMHMTAEALEEIESQIQKFMVQNRSASERNSSGDADSAHMEYPYGELIISLGFFFVFFLESLALQCCPGAAGGSTVQDEEWGGAHIFELHSHGHLPSPSKGPLRALVLLLSLSFHSVFEGLAVGLQPTVAATVQLCLAVLAHKGLVVFGVGMRLVHLGTSSRWAVFSILLLALMSPLGLAVGLAVTGGDSEGGRGLAQAVLEGVAAGTFLYVTFLEILPRELASPEAPLAKWSCVAAGFAFMAFIALWA
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NP94-1; Sequence=Displayed; Name=2; IsoId=Q9NP94-2; Sequence=VSP_046889, VSP_046890
Alternative Sequence
83..85; NRS -> ISK (in isoform 2); 86..309; Missing (in isoform 2)
Domain & Motif Annotations
Protein Families
ZIP transporter (TC 2.A.5) family
Sequence Similarities
Belongs to the ZIP transporter (TC 2.A.5) family.
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 30379855 | Harmonization of exosome isolation from culture supernatants for optimized proteomics analysis. | No abstract available |