Protein detail

LT4R2

Leukotriene B4 receptor 2 (LTB4-R 2) (LTB4-R2) (LTB4 receptor JULF2) (Leukotriene B4 receptor BLT2) (Seven transmembrane receptor BLTR2)

Entry name LT4R2	UniProt ID Q9NPC1	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 7	Protein classification G-protein coupled receptorsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Leukotriene B4 receptor 2 (LTB4-R 2) (LTB4-R2) (LTB4 receptor JULF2) (Leukotriene B4 receptor BLT2) (Seven transmembrane receptor BLTR2)

Protein Class (2)

G-protein coupled receptorsPredicted membrane proteins

Protein Function (2)

G-protein coupled receptors:Adenosine and adenine nucleotide receptors
G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

25..45; Helical; Name=1; 61..81; Helical; Name=2; 97..117; Helical; Name=3; 141..161; Helical; Name=4; 186..206; Helical; Name=5; 225..245; Helical; Name=6; 276..296; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000213906

Entrez Gene Symbol

LTB4R2

Gene Synonym (4)

BLT2BLTR2JULF2NOP9

Gene Description

Leukotriene B4 receptor 2

Chromosome

Position

24305734-24312053

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization2

Tissue SpecificbrainCell SpecificAdrenal medulla cells

Function & Pathway8

Protein Function (2)

G-protein coupled receptors:Adenosine and adenine nucleotide receptors
G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component (3)

Molecular Function (3)

Biological Process (3)

KEGG (2)

Reactome (6)

Canonical Pathways (3)

M11736 Sa mmp cytokine connection
M162 Pid rxr vdr pathway
M36 Pid il27 pathway

Mediation Categories (2)

Clinical-translation mediationReceptor-signaling mediation

Relations & Evidence48

Enzyme-Mediated Modification (1)

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
LTB4R2	AKT1	P31749	T	324	phosphorylation	MIMPPhosphoSiteSIGNORPhosphoSite_MIMP	SIGNOR:22044535

Ligand-Receptor Signaling (43)

43 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
leukotriene_b4_7tm_a	receptor	HPMR	No	Yes	No	Yes	No
rhodopsin	receptor	Surfaceome	No	Yes	No	Yes	No
gpcr	receptor	Surfaceome	No	Yes	No	Yes	No
class_a_rhodopsin	receptor	GPCRdb	No	Yes	No	Yes	No
class_a_rhodopsin_lipid	receptor	GPCRdb	No	Yes	No	Yes	No
class_a_rhodopsin_lipid_leukotriene	receptor	GPCRdb	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	HPMR	No	No	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	ComPPI	No	No	No	Yes	No

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Regulatory Interaction Network (3)

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
LT4R2	Q9NPC1	GNAI3	P08754	Yes	Yes	No	SIGNOR	SIGNOR:31160049
LT4R2	Q9NPC1	GNAI1	P63096	Yes	Yes	No	SIGNOR	SIGNOR:31160049
AKT1	P31749	LT4R2	Q9NPC1	Yes	No	No	PhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	SIGNOR:22044535 PhosphoSite:22044535 ProtMapper:22044535 PhosphoSite:23928309

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Western blotting	1	39996590

Sequence, Structure & Domains7

Sequences

Length

358

Mass

37,942

Sequence

MSVCYRPPGNETLLSWKTSRATGTAFLLLAALLGLPGNGFVVWSLAGWRPARGRPLAATLVLHLALADGAVLLLTPLFVAFLTRQAWPLGQAGCKAVYYVCALSMYASVLLTGLLSLQRCLAVTRPFLAPRLRSPALARRLLLAVWLAALLLAVPAAVYRHLWRDRVCQLCHPSPVHAAAHLSLETLTAFVLPFGLMLGCYSVTLARLRGARWGSGRHGARVGRLVSAIVLAFGLLWAPYHAVNLLQAVAALAPPEGALAKLGGAGQAARAGTTALAFFSSSVNPVLYVFTAGDLLPRAGPRFLTRLFEGSGEARGGGRSREGTMELRTTPQLKVVGQGRGNGDPGGGMEKDGPEWDL

Domain & Motif Annotations

Compositional Bias

338..348; Gly residues; 349..358; Basic and acidic residues

Region

311..358; Disordered

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance4

Related Diseases (4)

Asthma Human immunodeficiency virus disease Indeterminate colitis Renal cell carcinoma

Biomarker

Terminated; Phase 2; Discontinued in Phase 2; Phase 1

Drugs (4)

CP-195543 NOMACOPAN BIOMED 101 LTB4

Antibody (3)

CAB022689 HPA029680 HPA072921

Supporting Publications1

PMID	Title	Abstract
40326690	Rapid Identification of Esophageal Squamous Cell Carcinoma Biomarkers by MALDI-TOF MS Fingerprinting of Extracellular Vesicles.	No abstract available