Protein detail

C1QR1

Complement component C1q receptor (C1q/MBL/SPA receptor) (C1qR) (C1qR(p)) (C1qRp) (CDw93) (Complement component 1 q subcomponent receptor 1) (Matrix-remodeling-associated protein 4) (CD antigen CD93)

Entry name C1QR1	UniProt ID Q9NPY3	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 1	Protein classification CD markersPlasma proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Complement component C1q receptor (C1q/MBL/SPA receptor) (C1qR) (C1qR(p)) (C1qRp) (CDw93) (Complement component 1 q subcomponent receptor 1) (Matrix-remodeling-associated protein 4) (CD antigen CD93)

Protein Class (3)

CD markersPlasma proteinsPredicted membrane proteins

Protein Function

CD markers

Transmembrane

581..601; Helical

Transmembrane Count

Ensembl

ENSG00000125810

Entrez Gene Symbol

CD93

Gene Synonym (7)

C1qR(P)C1QR1C1qRPCDw93dJ737E23.1ECSM3MXRA4

Gene Description

CD93 molecule

Chromosome

Position

23079360-23086324

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization2

Cell SpecificConjunctival goblet cellsSingle-Nuclei Brain Specificoligodendrocyte

Function & Pathway7

Protein Function

CD markers

Cellular Component (6)

Molecular Function (5)

Biological Process (3)

Reactome (2)

Canonical Pathways

M286 Pid tgfbr pathway

Mediation Categories (2)

Fusion and delivery mediationImmune mediation

Relations & Evidence60

Enzyme-Mediated Modification (2)

2 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
CD93	SRC	P12931	Y	644	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper
CD93	SRC	P12931	Y	628	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper

Ligand-Receptor Signaling (57)

57 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	TopDB	No	No	No	Yes	No
transmembrane	transmembrane	LOCATE	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	Cellinker	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	HPMR	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometryMass spectrometry [LTQ-FT Ultra]	1	40089067

Sequence, Structure & Domains10

Sequences

Length

652

Mass

68,560

Sequence

MATSMGLLLLLLLLLTQPGAGTGADTEAVVCVGTACYTAHSGKLSAAEAQNHCNQNGGNLATVKSKEEAQHVQRVLAQLLRREAALTARMSKFWIGLQREKGKCLDPSLPLKGFSWVGGGEDTPYSNWHKELRNSCISKRCVSLLLDLSQPLLPSRLPKWSEGPCGSPGSPGSNIEGFVCKFSFKGMCRPLALGGPGQVTYTTPFQTTSSSLEAVPFASAANVACGEGDKDETQSHYFLCKEKAPDVFDWGSSGPLCVSPKYGCNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQDSPCAQECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSCTMGPVSLGPPSGPPDEEDKGEKEGSTVPRAATASPTRGPEGTPKATPTTSRPSLSSDAPITSAPLKMLAPSGSPGVWREPSIHHATAASGPQEPAGGDSSVATQNNDGTDGQKLLLFYILGTVVAILLLLALALGLLVYRKRRAKREEKKEKKPQNAADSYSWVPERAESRAMENQYSPTPGTDC

3D Structural Models

Turn

110..113; 260..266

Helix

46..55; 66..82; 267..270

Beta Strand

29..32; 35..41; 89..99; 101..103; 136..138; 140..147; 154..156; 159..163; 175..183; 198..202; 204..206; 208..210; 213..216; 220..224; 237..239; 241..244; 247..249; 272..277; 279..281; 283..286; 291..293; 300..302

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Compositional Bias

512..526; Polar residues; 612..621; Basic and acidic residues; 640..652; Polar residues

Domain (FT)

32..174; C-type lectin; 260..301; EGF-like 1; 302..344; EGF-like 2; 345..384; EGF-like 3; calcium-binding; 385..426; EGF-like 4; calcium-binding; 427..468; EGF-like 5; calcium-binding

Region

472..546; Disordered; 553..572; Disordered; 611..652; Disordered

Clinical Relevance1

Antibody (2)

HPA009300 HPA012368

Supporting Publications1

PMID	Title	Abstract
24670152	Quantitative proteomics of extracellular vesicles released from human monocyte-derived macrophages upon β-glucan stimulation.	No abstract available