Protein detail
EQTN
Equatorin (Acrosome formation-associated factor)
Entry name EQTN | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification Predicted membrane proteinsPredicted secreted proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Equatorin (Acrosome formation-associated factor)
Protein Class (2)
Predicted membrane proteinsPredicted secreted proteins
Protein Function
Predicted secreted proteins
Transmembrane
182..202; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
AFAFC9orf11equatorinSPACA8
Gene Description
Equatorin
Chromosome
9
Position
27284654-27297150
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization5
Cell SpecificColonocytesSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificneutrophilBlood Lineage Specificdendritic cells
Function & Pathway5
Protein Function
Predicted secreted proteins
Cellular Component (3)
Biological Process (3)
Canonical Pathways (3)
- M3468 Naba ecm regulators
- M5885 Naba matrisome associated
- M5889 Naba matrisome
Mediation Categories
Fusion and delivery mediation
Relations & Evidence16
Ligand-Receptor Signaling (15)
15 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane_predicted | transmembrane | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | No | No |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | ELISA | 1 | 37322475 |
Sequence, Structure & Domains6
Sequences
Length
294
Mass
32,840
Sequence
MNFILFIFIPGVFSLKSSTLKPTIEALPNVLPLNEDVNKQEEKNEDHTPNYAPANEKNGNYYKDIKQYVFTTQNPNGTESEISVRATTDLNFALKNDKTVNATTYEKSTIEEETTTSEPSHKNIQRSTPNVPAFWTMLAKAINGTAVVMDDKDQLFHPIPESDVNATQGENQPDLEDLKIKIMLGISLMTLLLFVVLLAFCSATLYKLRHLSYKSCESQYSVNPELATMSYFHPSEGVSDTSFSKSAESSTFLGTTSSDMRRSGTRTSESKIMTDIISIGSDNEMHENDESVTR
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9NQ60-1; Sequence=Displayed; Name=2; IsoId=Q9NQ60-2; Sequence=VSP_025109, VSP_025110; Name=3; IsoId=Q9NQ60-3; Sequence=VSP_042157
Alternative Sequence
97..126; DKTVNATTYEKSTIEEETTTSEPSHKNIQR -> G (in isoform 3); 126..127; RS -> SI (in isoform 2); 128..294; Missing (in isoform 2)
Domain & Motif Annotations
Region
107..126; Disordered
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 38343172 | Analysis of secreted small extracellular vesicles from activated human microglial cell lines reveals distinct pro- and anti-inflammatory proteomic profiles. | No abstract available |