Protein detail
ANO2
Anoctamin-2 (Transmembrane protein 16B)
Entry name ANO2 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 2 | Transmembrane count 8 | Protein classification Predicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Anoctamin-2 (Transmembrane protein 16B)
Protein Class (2)
Predicted membrane proteinsTransporters
Protein Function
Transporters:Transporter channels and pores
Transmembrane
365..385; Helical; 434..454; Helical; 534..554; Helical; 578..598; Helical; 619..639; Helical; 744..764; Helical; 797..817; Helical; 903..923; Helical
Transmembrane Count
8
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
C12orf3TMEM16B
Gene Description
Anoctamin 2
Chromosome
12
Position
5531869-5946232
Supporting publications (n)
2
EVMP confidence score
0.50
Fluorescence & Localization3
Tissue SpecificretinaCell SpecificNeutrophils
Function & Pathway8
Protein Function
Transporters:Transporter channels and pores
Cellular Component (3)
Molecular Function (4)
Biological Process (3)
Reactome (11)
- R-hsa-9733458 induction of cell cell fusion
- R-hsa-5663205 infectious disease
- R-hsa-983712 ion channel transport
- R-hsa-9772573 late sars cov 2 infection events
- R-hsa-381753 olfactory signaling pathway
- R-hsa-9694516 sars cov 2 infection
- R-hsa-9679506 sars cov infections
- R-hsa-9709957 sensory perception
- R-hsa-2672351 stimuli sensing channels
- R-hsa-382551 transport of small molecules
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Canonical Pathways (3)
- M165 Pid syndecan 4 pathway
- M277 Pid integrin a4b1 pathway
- M53 Pid integrin3 pathway
Mediation Categories (2)
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence17
Ligand-Receptor Signaling (16)
16 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| ion_channel | ion_channel | DGIdb | No | Yes | No | No | No |
| tmem16_calcium_dependent_chloride | ion_channel | OmniPath | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
| ion_channel | ion_channel | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry；RNA Sequencing；Flow cytometry | 1 | 41307968 |
Sequence, Structure & Domains10
Sequences
Length
998
Mass
113,356
Sequence
MATPGPRDIPLLPGSPRRLSPQAGSRGGQGPKHGQQCLKMPGPRAPGLQGGSNRDPGQPCGGESTRSSSVINNYLDANEPVSLEARLSRMHFHDSQRKVDYVLAYHYRKRGVHLAQGFPGHSLAIVSNGETGKEPHAGGPGDIELGPLDALEEERKEQREEFEHNLMEAGLELEKDLENKSQGSIFVRIHAPWQVLAREAEFLKIKVPTKKMYEIKAGGSIAKKFSAALQKLSSHLQPRVPEHSNNKMKNLSYPFSREKMYLYNIQEKDTFFDNATRSRIVHEILKRTACSRANNTMGINSLIANNIYEAAYPLHDGEYDSPEDDMNDRKLLYQEWARYGVFYKFQPIDLIRKYFGEKIGLYFAWLGLYTSFLIPSSVIGVIVFLYGCATIEEDIPSREMCDQQNAFTMCPLCDKSCDYWNLSSACGTAQASHLFDNPATVFFSIFMALWATMFLENWKRLQMRLGYFWDLTGIEEEEEHSRPEYETKVREKMLKESNQSAVQKLETNTTECGDEDDEDKLTWKDRFPGYLMNFASILFMIALTFSIVFGVIVYRITTAAALSLNKATRSNVRVTVTATAVIINLVVILILDEIYGAVAKWLTKIEVPKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRPGSYVYVFDGYRMEECAPGGCLMELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEAGETDSAHSKHPEQWDLDYSLEPYTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSVISNAFVIAITSDFIPRLVYQYSYSHNGTLHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWFILSARLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEKLKLMDEPALRSPGGGDRSRSRAASSAPSGQSQLGSMMSSGSQHTNV
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9NQ90-4; Sequence=Displayed; Name=2; IsoId=Q9NQ90-1; Sequence=VSP_062664, VSP_062665; Name=3; IsoId=Q9NQ90-2; Sequence=VSP_062663, VSP_062664, VSP_062665
Alternative Sequence
1..7; MATPGPR -> MPE (in isoform 3); 211; K -> KE (in isoform 2 and isoform 3); 478; E -> EERAQ (in isoform 2 and isoform 3)
Domain & Motif Annotations
Compositional Bias
10..21; Low complexity
Motif
996..998; DLG4 binding (PDZ)
Region
1..68; Disordered
Protein Families
Anoctamin family
Sequence Similarities
Belongs to the anoctamin family.
Clinical Relevance2
Supporting Publications2
| PMID | Title | Abstract |
|---|---|---|
| 35868309 | Mechanical force-promoted osteoclastic differentiation via periodontal ligament stem cell exosomal protein ANXA3. | Collectively, this study demonstrates that mechanical force treatment promotes the biogenesis of exosomes from PDLSCs and increases exosomal protein ANXA3 to facilitate exosome internalization, which activates ERK phosphorylation, thus inducing osteoclast differentiation. Mechanistically, mechanical force increases the level of exosomal proteins, especially annexin A3 (ANXA3), which facilitates exosome internalization to activate extracellular signal-regulated kinase (ERK), thus inducing osteoclast differentiation. |
| 38393971 | ANXA3-Rich Exosomes Derived from Tumor-Associated Macrophages Regulate Ferroptosis and Lymphatic Metastasis of Laryngeal Squamous Cell Carcinoma. | No abstract available |