Protein detail
AVEN
Cell death regulator Aven
Protein symbol AVEN | UniProt ID | EVMP score 0.63 |
Frequency 8 | Transmembrane count | Protein classification Predicted intracellular proteins |
Basic Information
Protein Names
Cell death regulator Aven
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
PDCD12
Gene Description
Apoptosis and caspase activation inhibitor
Chromosome
15
Position
33858782-34075155
Frequency
8
EVMP Score
0.63
Fluorescence & Localization
Tissue SpecificplacentaCell SpecificKupffer cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificnon-classical monocyte
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Other mediation
Relations & Evidence
Enzyme-Mediated Modification
2 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| AVEN | ATM | Q13315 | S | 135 | phosphorylation | PhosphoSite_MIMPMIMPSIGNORProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:18571408 |
| AVEN | ATM | Q13315 | S | 308 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:18571408 |
Ligand-Receptor Signaling
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| ATM | Q13315 | AVEN | Q9NQS1 | Yes | Yes | No | PhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefSIGNORiPTMnetProtMapperSIGNOR_ProtMapperSPIKEPhosphoSite_ProtMapperSPIKE_LC | SPIKE_LC:18571408SIGNOR:18571408ProtMapper:18571408SPIKE:18571408 |
| AVEN | Q9NQS1 | ATM | Q13315 | Yes | Yes | No | SPIKESPIKE_LCSIGNOR | SPIKE_LC:18571408SIGNOR:18571408SPIKE:18571408 |
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
362
Mass
38,506
Sequence
MQAERGARGGRGRRPGRGRPGGDRHSERPGAAAAVARGGGGGGGGDGGGRRGRGRGRGFRGARGGRGGGGAPRGSRREPGGWGAGASAPVEDDSDAETYGEENDEQGNYSKRKIVSNWDRYQDIEKEVNNESGESQRGTDFSVLLSSAGDSFSQFRFAEEKEWDSEASCPKQNSAFYVDSELLVRALQELPLCLRLNVAAELVQGTVPLEVPQVKPKRTDDGKGLGMQLKGPLGPGGRGPIFELKSVAAGCPVLLGKDNPSPGPSRDSQKPTSPLQSAGDHLEEELDLLLNLDAPIKEGDNILPDQTSQDLKSKEDGEVVQEEEVCAKPSVTEEKNMEPEQPSTSKNVTEEELEDWLDSMIS
3D Structural Models
Domain & Motif Annotations
Compositional Bias
8..17; Basic residues; 37..47; Gly residues; 50..60; Basic residues; 61..72; Gly residues; 90..105; Acidic residues; 350..362; Acidic residues
Region
1..111; Disordered; 214..237; Disordered; 253..362; Disordered
Clinical Relevance
Antibody