Protein detail
S17A5
Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Membrane glycoprotein HP59) (Solute carrier family 17 member 5) (Vesicular excitatory amino acid transporter) (VEAT)
Entry name S17A5 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 12 | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Membrane glycoprotein HP59) (Solute carrier family 17 member 5) (Vesicular excitatory amino acid transporter) (VEAT)
Protein Function
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of glycan/glycoprotein metabolism
- Potential drug targets
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
- Human disease related genes:Congenital disorders of metabolism:Lysosomal storage diseases
Transmembrane
42..62; Helical; 110..130; Helical; 137..157; Helical; 159..179; Helical; 201..221; Helical; 228..248; Helical; 280..300; Helical; 329..349; Helical; 366..386; Helical; 392..412; Helical; 424..444; Helical; 458..478; Helical
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of glycan/glycoprotein metabolism
- Potential drug targets
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
- Human disease related genes:Congenital disorders of metabolism:Lysosomal storage diseases
Cellular Component
Molecular Function
Biological Process
Reactome
- R-hsa-446203 asparagine n linked glycosylation
- R-hsa-446193 biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein
- R-hsa-5619115 disorders of transmembrane transporters
- R-hsa-1630316 glycosaminoglycan metabolism
- R-hsa-2160916 hyaluronan degradation
- R-hsa-2142845 hyaluronan metabolism
- R-hsa-71387 metabolism of carbohydrates and carbohydrate derivatives
- R-hsa-428643 organic anion transport by slc5 17 25 transporters
- R-hsa-597592 post translational protein modification
- R-hsa-4085001 sialic acid metabolism
- R-hsa-425407 slc mediated transmembrane transport
- R-hsa-9955298 slc mediated transport of organic anions
- R-hsa-5619102 slc transporter disorders
- R-hsa-446219 synthesis of substrates in n glycan biosythesis
- R-hsa-382551 transport of small molecules
Canonical Pathways
- M69 Pid reelin pathway
- M163 Pid lis1 pathway
- M177 Pid epha fwdpathway
Mediation Categories
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
26 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| basolateral_cell_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | No | No |
| cell_surface | cell_surface | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 27605433 |
Sequence, Structure & Domains
Sequences
Length
495
Mass
54,640
Sequence
MRSPVRDLARNDGEESTDRTPLLPGAPRAEAAPVCCSARYNLAILAFFGFFIVYALRVNLSVALVDMVDSNTTLEDNRTSKACPEHSAPIKVHHNQTGKKYQWDAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVGPLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRISHYEKEYILSSLRNQLSSQKSVPWVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWNFSTLCVRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATIPGMVGPVIAKSLTPDNTVGEWQTVFYIAAAINVFGAIFFTLFAKGEVQNWALNDHHGHRH
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NRA2-1; Sequence=Displayed; Name=2; IsoId=Q9NRA2-2; Sequence=VSP_010482, VSP_010483
Alternative Sequence
274..276; LSS -> AGV (in isoform 2); 278..495; Missing (in isoform 2)
3D Structural Models
Turn
120..122; 252..254; 271..275; 358..361; 385..387
Helix
38..67; 105..119; 124..133; 135..150; 153..159; 161..176; 178..189; 192..194; 195..223; 227..247; 260..270; 282..287; 289..318; 324..355; 362..384; 389..402; 403..407; 410..413; 414..417; 419..421; 422..433; 435..447; 453..477; 484..486
Beta Strand
34..37; 279..281
3D Structure
Electron microscopy (7)
Domain & Motif Annotations
Compositional Bias
1..18; Basic and acidic residues
Motif
22..23; Dileucine internalization motif
Region
1..24; Disordered
Protein Families
- Major facilitator superfamily
- Sodium/anion cotransporter family
Sequence Similarities
Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.