Protein detail

SNRK

SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1-related kinase)

Entry name SNRK	UniProt ID Q9NRH2	EVMP confidence score 0.38
Supporting publications (n) 3	Transmembrane count	Protein classification EnzymesPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1-related kinase)

Protein Class (2)

EnzymesPredicted intracellular proteins

Protein Function (4)

ENZYME proteins:Transferases
Enzymes
Predicted intracellular proteins
Kinases:CAMK Ser/Thr protein kinases

Ensembl

ENSG00000163788

Entrez Gene Symbol

SNRK

Gene Synonym (3)

FLJ20224HSNFRKKIAA0096

Gene Description

SNF related kinase

Chromosome

Position

43286512-43424764

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization5

Tissue SpecificintestineCell SpecificGoblet cellsSingle-Nuclei Brain Specificcentral nervous system macrophageSecretome LocationSecreted in other tissues

Function & Pathway6

Protein Function (4)

ENZYME proteins:Transferases
Enzymes
Predicted intracellular proteins
Kinases:CAMK Ser/Thr protein kinases

Cellular Component

GO:0005634 nucleus

Molecular Function (5)

Biological Process (3)

Canonical Pathways

M254 Pid myc repress pathway

Mediation Categories

Immune mediation

Relations & Evidence17

Enzyme-Mediated Modification (2)

2 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
SNRK	STK11	Q15831	T	173	phosphorylation	PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDRLIMS-P_ProtMapperdbPTMKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	dbPTM:15733851 ProtMapper:15733851 HPRD:15733851 phosphoELM:15733851 KEA:15733851 SIGNOR:15733851
SNRK	STK11	Q15831	S	569	phosphorylation	PhosphoNetworks

Ligand-Receptor Signaling (9)

9 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transmembrane	transmembrane	LOCATE	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
receptor	receptor	scConnect	No	Yes	No	No	No

Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
STK11	Q15831	SNRK	Q9NRH2	Yes	Yes	No	HPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperdbPTMPhosphoSite_KEAphosphoELM_KEAPhosphoNetworksHPRDKinexus_KEAWangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperPhosphoSiteSPIKE_LCHPRD-phos	HPRD-phos:15733851 dbPTM:15733851 ProtMapper:15733851 PhosphoSite:15733851 HPRD:15733851 phosphoELM:15733851 KEA:15733851 SPIKE_LC:15733851 SIGNOR:15733851

Protein Complex Composition (4)

4 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
HSPA1B PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 SNRK STK11 STK16 ULK1 ULK2	O43741 O75385 O75716 P0DMV9 P54619 P54646 Q13131 Q15831 Q8IYT8 Q9NRH2 Q9UGI9 Q9UGJ0 Q9Y478	1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6222
CIAPIN1 HSPA1B SNRK STK11 STK16	O75716 P0DMV9 Q15831 Q6FI81 Q9NRH2	1:1:1:1:1	NetworkBlastCompleat	Compleat:HC3915
FABP4 GDF5 SNRK TMEM102 TNNC2	P02585 P15090 P43026 Q8N9M5 Q9NRH2	0:0:0:0:0	hu.MAP2
SNRK	Q9NRH2	2	PDB	PDB:5yks

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	38347590

Sequence, Structure & Domains14

Sequences

Length

765

Mass

84,276

Sequence

MAGFKRGYDGKIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRDPKRRASLEEIENHPWLQGVDPSPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDIADRDAIVEALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQFRQSWPTKIDVPQDLEDDLTATPLSHATVPQSPARAADSVLNGHRSKGLCDSAKKDDLPELAGPALSTVPPASLKPTASGRKCLFRVEEDEEEDEEDKKPMSLSTQVVLRRKPSVTNRLTSRKSAPVLNQIFEEGESDDEFDMDENLPPKLSRLKMNIASPGTVHKRYHRRKSQGRGSSCSSSETSDDDSESRRRLDKDSGFTYSWHRRDSSEGPPGSEGDGGGQSKPSNASGGVDKASPSENNAGGGSPSSGSGGNPTNTSGTTRRCAGPSNSMQLASRSAGELVESLKLMSLCLGSQLHGSTKYIIDPQNGLSFSSVKVQEKSTWKMCISSTGNAGQVPAVGGIKFFSDHMADTTTELERIKSKNLKNNVLQLPLCEKTISVNIQRNPKEGLLCASSPASCCHVI

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NRH2-1; Sequence=Displayed; Name=2; IsoId=Q9NRH2-2; Sequence=VSP_051959, VSP_051960

Alternative Sequence

244; D -> E (in isoform 2); 245..765; Missing (in isoform 2)

3D Structural Models

Turn

149..152; 162..164; 254..256

Helix

54..67; 100..105; 113..132; 142..144; 183..187; 193..210; 220..229; 240..249; 260..265; 267..269; 284..286; 292..304; 310..319; 324..343

Beta Strand

26..33; 36..52; 78..83; 85..92; 145..148; 153..156

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

522..532; Basic residues; 533..542; Low complexity; 549..558; Basic and acidic residues; 603..614; Gly residues

Domain (FT)

16..269; Protein kinase; 291..334; UBA

Region

512..634; Disordered

Protein Families (2)

Protein kinase superfamily
CAMK Ser/Thr protein kinase family

Sequence Similarities

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.

Clinical Relevance4

Antibody

HPA042163

Interaction Protein

ENSG00000070808

Interaction Count

Interaction Dataset

biogrid_bioplex

Supporting Publications3

PMID	Title	Abstract
33709510	Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection.	No abstract available
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available
39835386	Comparison of nanoLC-MALDI-MS/MS with nanoLC-TIMS-MS/MS in the proteomic analysis of extracellular vesicles of bronchoalveolar lavage fluid.	No abstract available