Protein detail
I17RB
Interleukin-17 receptor B (IL-17 receptor B) (IL-17RB) (Cytokine receptor-like 4) (IL-17 receptor homolog 1) (IL-17Rh1) (IL17Rh1) (Interleukin-17B receptor) (IL-17B receptor)
Entry name I17RB | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 6 | Transmembrane count 1 | Protein classification Predicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information12
Protein Names
Interleukin-17 receptor B (IL-17 receptor B) (IL-17RB) (Cytokine receptor-like 4) (IL-17 receptor homolog 1) (IL-17Rh1) (IL17Rh1) (Interleukin-17B receptor) (IL-17B receptor)
Protein Class
Predicted membrane proteins
Transmembrane
293..313; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
CRL4EVI27IL17BRIL17RH1
Gene Description
Interleukin 17 receptor B
Chromosome
3
Position
53846568-53865794
Supporting publications (n)
6
EVMP confidence score
0.50
Fluorescence & Localization2
Tissue SpecificbrainCell SpecificBrain excitatory neurons
Function & Pathway6
Cellular Component (4)
Molecular Function (3)
Biological Process (3)
Reactome (3)
Mediation Categories
Immune mediation
Relations & Evidence75
Enzyme-Mediated Modification (1)
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| IL17RB | MAP3K21 | Q5TCX8 | Y | 447 | phosphorylation | PhosphoSite |
Ligand-Receptor Signaling (65)
65 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellPhoneDB | No | Yes | Yes | Yes | No |
| receptor | receptor | GO_Intercell | No | Yes | Yes | Yes | No |
| receptor | receptor | HPMR | No | Yes | Yes | Yes | No |
| receptor | receptor | ICELLNET | No | Yes | Yes | Yes | No |
| receptor | receptor | CellChatDB | No | Yes | Yes | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | Yes | Yes | No |
| receptor | receptor | Surfaceome | No | Yes | Yes | Yes | No |
| receptor | receptor | Ramilowski2015 | No | Yes | Yes | Yes | No |
| receptor | receptor | Kirouac2010 | No | Yes | Yes | Yes | No |
| receptor | receptor | Guide2Pharma | No | Yes | Yes | Yes | No |
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Regulatory Interaction Network (2)
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| IL17B | Q9UHF5 | I17RB | Q9NRM6 | Yes | Yes | No | iTALKKirouac2010ICELLNETSIGNORHINTInnateDBUniProt_LRdbHPMR_talklrCellChatDBHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbHPRD_talklrBaccin2019CellinkerGuide2PharmaFantom5_LRdbCellTalkDBHPMR_CellinkerconnectomeDB2020LRdb | InnateDB:10749887HINT:11058597InnateDB:11058597CellTalkDB:10749887HPRD:10749887connectomeDB2020:10749887Baccin2019:1074988710749880SIGNOR:10749887LRdb:10749887ICELLNET:24011563Cellinker:10749887HINT:10749887 |
| M3K21 | Q5TCX8 | I17RB | Q9NRM6 | Yes | No | No | PhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:33658352 |
Protein Complex Composition (6)
6 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| IL17_receptor_AB | IL17RAIL17RB | Q96F46Q9NRM6 | 1:1 | CellPhoneDBCellinkerGuide2PharmaCellChatDB | CellPhoneDB:IL17_receptor_AB | |
| Interleukin-17B receptor-ligand complex | IL17BIL17RAIL17RBTRAF3IP2 | O43734Q96F46Q9NRM6Q9UHF5 | 4:2:2:2 | ComplexPortal | intact:EBI-54439443 | 323731323174533730770417282541693586337814755292 |
| Interleukin-25 receptor-ligand complex | IL17RAIL17RBIL25TRAF3IP2 | O43734Q96F46Q9H293Q9NRM6 | 4:2:2:2 | ComplexPortal | PDB:7UWKPDB:7UWJintact:EBI-54439392PDB:7UWL | 38045694334856513174533728254169358633781475529230738055 |
| ATG101ATG13FAM221BIL17RBRB1CC1SELENOO | A6H8Z2O75143Q8TDY2Q9BSB4Q9BVL4Q9NRM6 | 0:0:0:0:0:0 | hu.MAP2 | |||
| IL17RAIL17RBIL25 | Q96F46Q9H293Q9NRM6 | 2:2:2 | PDB | PDB:7uwl | ||
| IL17RBIL25 | Q9H293Q9NRM6 | 2:2 | PDB | PDB:7uwjPDB:7uwk |
Sequence, Structure & Domains10
Sequences
Length
502
Mass
55,885
Sequence
MSLVLLSLAALCRSAVPREPTVQCGSETGPSPEWMLQHDLIPGDLRDLRVEPVTTSVATGDYSILMNVSWVLRADASIRLLKATKICVTGKSNFQSYSCVRCNYTEAFQTQTRPSGGKWTFSYIGFPVELNTVYFIGAHNIPNANMNEDGPSMSVNFTSPGCLDHIMKYKKKCVKAGSLWDPNITACKKNEETVEVNFTTTPLGNRYMALIQHSTIIGFSQVFEPHQKKQTRASVVIPVTGDSEGATVQLTPYFPTCGSDCIRHKGTVVLCPQTGVPFPLDNNKSKPGGWLPLLLLSLLVATWVLVAGIYLMWRHERIKKTSFSTTTLLPPIKVLVVYPSEICFHHTICYFTEFLQNHCRSEVILEKWQKKKIAEMGPVQWLATQKKAADKVVFLLSNDVNSVCDGTCGKSEGSPSENSQDLFPLAFNLFCSDLRSQIHLHKYVVVYFREIDTKDDYNALSVCPKYHLMKDATAFCAELLHVKQQVSAGKRSQACHDGCCSL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NRM6-1; Sequence=Displayed; Name=2; IsoId=Q9NRM6-2; Sequence=VSP_001740, VSP_001741
Alternative Sequence
250..288; LTPYFPTCGSDCIRHKGTVVLCPQTGVPFPLDNNKSKPG -> VKFSELLWGGKGHRRLFHHSLLLRMSSLLSNALLPADTS (in isoform 2); 289..502; Missing (in isoform 2)
3D Structural Models
Turn
255..259
Helix
32..35; 171..176
Beta Strand
22..24; 49..55; 63..70; 83..90; 92..94; 96..106; 121..127; 133..142; 154..158; 162..165; 168..170; 185..187; 190..197; 205..207; 210..219; 235..238; 247..250; 263..267
3D Structure
Electron microscopy (3)
Domain & Motif Annotations
Domain (FT)
331..477; SEFIR
Clinical Relevance1
Antibody
Supporting Publications6
| PMID | Title | Abstract |
|---|---|---|
| 24505114 | Proteomics analysis of cancer exosomes using a novel modified aptamer-based array (SOMAscan™) platform. | These included proteins of known association with cancer exosomes such as MFG-E8, integrins, and MET, and also those less widely reported as exosomally associated, such as ROR1 and ITIH4. |
| 28242843 | Label-free Proteomic Analysis of Exosomes Derived from Inducible Hepatitis B Virus-Replicating HepAD38 Cell Line. | No abstract available |
| 31588238 | Dual-platform affinity proteomics identifies links between the recurrence of ovarian carcinoma and proteins released into the tumor microenvironment. | No abstract available |
| 37686366 | Identification of a Non-Invasive Urinary Exosomal Biomarker for Diabetic Nephropathy Using Data-Independent Acquisition Proteomics. | No abstract available |
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No abstract available |
| 40098346 | Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays. | No abstract available |