Protein detail

I17RB

Interleukin-17 receptor B (IL-17 receptor B) (IL-17RB) (Cytokine receptor-like 4) (IL-17 receptor homolog 1) (IL-17Rh1) (IL17Rh1) (Interleukin-17B receptor) (IL-17B receptor)

Protein symbol I17RB	UniProt ID Q9NRM6	EVMP score 0.50
Frequency 6	Transmembrane count 1	Protein classification Predicted membrane proteins

Basic Information

Protein Names

Interleukin-17 receptor B (IL-17 receptor B) (IL-17RB) (Cytokine receptor-like 4) (IL-17 receptor homolog 1) (IL-17Rh1) (IL17Rh1) (Interleukin-17B receptor) (IL-17B receptor)

Protein Class

Predicted membrane proteins

Transmembrane

293..313; Helical

Transmembrane Count

Ensembl

ENSG00000056736

Entrez Gene Symbol

IL17RB

Gene Synonym

CRL4EVI27IL17BRIL17RH1

Gene Description

Interleukin 17 receptor B

Chromosome

Position

53846568-53865794

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue SpecificbrainCell SpecificBrain excitatory neurons

Function & Pathway

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Immune mediation

Relations & Evidence

Enzyme-Mediated Modification

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
IL17RB	MAP3K21	Q5TCX8	Y	447	phosphorylation	PhosphoSite

Ligand-Receptor Signaling

65 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
extracellular	extracellular	HPMR	No	No	Yes	Yes	No
extracellular	extracellular	OmniPath	No	No	Yes	Yes	No
intracellular	intracellular	ComPPI	No	No	Yes	Yes	No
intracellular	intracellular	GO_Intercell	No	No	Yes	Yes	No
intracellular	intracellular	OmniPath	No	No	Yes	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	Yes	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	Yes	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	Yes	Yes	No
transmembrane_predicted	transmembrane	OmniPath	No	No	Yes	Yes	No
transmembrane	transmembrane	GO_Intercell	No	No	Yes	Yes	No

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Regulatory Interaction Network

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
IL17B	Q9UHF5	I17RB	Q9NRM6	Yes	Yes	No	iTALKKirouac2010ICELLNETSIGNORHINTInnateDBUniProt_LRdbHPMR_talklrCellChatDBHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbHPRD_talklrBaccin2019CellinkerGuide2PharmaFantom5_LRdbCellTalkDBHPMR_CellinkerconnectomeDB2020LRdb	InnateDB:10749887 HINT:11058597 InnateDB:11058597 CellTalkDB:10749887 HPRD:10749887 connectomeDB2020:10749887Baccin2019:1074988710749880SIGNOR:10749887 LRdb:10749887 ICELLNET:24011563 Cellinker:10749887 HINT:10749887
M3K21	Q5TCX8	I17RB	Q9NRM6	Yes	No	No	PhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:33658352

Protein Complex Composition

6 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
IL17_receptor_AB	IL17RA IL17RB	Q96F46 Q9NRM6	1:1	CellPhoneDBCellinkerGuide2PharmaCellChatDB	CellPhoneDB:IL17_receptor_AB
Interleukin-17B receptor-ligand complex	IL17B IL17RA IL17RB TRAF3IP2	O43734 Q96F46 Q9NRM6 Q9UHF5	4:2:2:2	ComplexPortal	intact:EBI-54439443	32373132 31745337 30770417 28254169 35863378 14755292
Interleukin-25 receptor-ligand complex	IL17RA IL17RB IL25 TRAF3IP2	O43734 Q96F46 Q9H293 Q9NRM6	4:2:2:2	ComplexPortal	PDB:7UWKPDB:7UWJintact:EBI-54439392PDB:7UWL	38045694 33485651 31745337 28254169 35863378 14755292 30738055
	ATG101 ATG13 FAM221B IL17RB RB1CC1 SELENOO	A6H8Z2 O75143 Q8TDY2 Q9BSB4 Q9BVL4 Q9NRM6	0:0:0:0:0:0	hu.MAP2
	IL17RA IL17RB IL25	Q96F46 Q9H293 Q9NRM6	2:2:2	PDB	PDB:7uwl
	IL17RB IL25	Q9H293 Q9NRM6	2:2	PDB	PDB:7uwjPDB:7uwk

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Western blottingFlow cytometry	2	38321535 40098346

Sequence, Structure & Domains

Sequences

Length

502

Mass

55,885

Sequence

MSLVLLSLAALCRSAVPREPTVQCGSETGPSPEWMLQHDLIPGDLRDLRVEPVTTSVATGDYSILMNVSWVLRADASIRLLKATKICVTGKSNFQSYSCVRCNYTEAFQTQTRPSGGKWTFSYIGFPVELNTVYFIGAHNIPNANMNEDGPSMSVNFTSPGCLDHIMKYKKKCVKAGSLWDPNITACKKNEETVEVNFTTTPLGNRYMALIQHSTIIGFSQVFEPHQKKQTRASVVIPVTGDSEGATVQLTPYFPTCGSDCIRHKGTVVLCPQTGVPFPLDNNKSKPGGWLPLLLLSLLVATWVLVAGIYLMWRHERIKKTSFSTTTLLPPIKVLVVYPSEICFHHTICYFTEFLQNHCRSEVILEKWQKKKIAEMGPVQWLATQKKAADKVVFLLSNDVNSVCDGTCGKSEGSPSENSQDLFPLAFNLFCSDLRSQIHLHKYVVVYFREIDTKDDYNALSVCPKYHLMKDATAFCAELLHVKQQVSAGKRSQACHDGCCSL

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NRM6-1; Sequence=Displayed; Name=2; IsoId=Q9NRM6-2; Sequence=VSP_001740, VSP_001741

Alternative Sequence

250..288; LTPYFPTCGSDCIRHKGTVVLCPQTGVPFPLDNNKSKPG -> VKFSELLWGGKGHRRLFHHSLLLRMSSLLSNALLPADTS (in isoform 2); 289..502; Missing (in isoform 2)

3D Structural Models

Turn

255..259

Helix

32..35; 171..176

Beta Strand

22..24; 49..55; 63..70; 83..90; 92..94; 96..106; 121..127; 133..142; 154..158; 162..165; 168..170; 185..187; 190..197; 205..207; 210..219; 235..238; 247..250; 263..267

3D Structure

Electron microscopy (3)

Domain & Motif Annotations

Domain (FT)

331..477; SEFIR

Clinical Relevance

Antibody

HPA005482