Protein detail
CNNM1
Metal transporter CNNM1 (Ancient conserved domain-containing protein 1) (Cyclin-M1)
Entry name CNNM1 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 4 | Protein classification Predicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Metal transporter CNNM1 (Ancient conserved domain-containing protein 1) (Cyclin-M1)
Protein Class (2)
Predicted membrane proteinsTransporters
Protein Function
Transporters:Transporter channels and pores
Transmembrane
23..43; Helical; 222..242; Helical; 282..302; Helical; 321..341; Helical
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Gene Synonym
ACDP1
Gene Description
Cyclin and CBS domain divalent metal cation transport mediator 1
Chromosome
10
Position
99329356-99394330
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization4
Tissue SpecifickidneyCell SpecificPodocytesSingle-Nuclei Brain Specificeccentric medium spiny neuron
Function & Pathway6
Protein Function
Transporters:Transporter channels and pores
Cellular Component
Molecular Function (2)
Biological Process (3)
Canonical Pathways
M264 Pid toll endogenous pathway
Mediation Categories
Metabolism mediation
Relations & Evidence12
Ligand-Receptor Signaling (11)
11 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture | Western blotting | 1 | 40098346 |
Sequence, Structure & Domains10
Sequences
Length
951
Mass
104,351
Sequence
MAAAAAAAAAVGVRLRDCCSRGAVLLLFFSLSPRPPAAAAWLLGLRPEDTAGGRVSLEGGTLRAAEGTSFLLRVYFQPGPPATAAPVPSPTLNSGENGTGDWAPRLVFIEEPPGGGGVAPSAVPTRPPGPQRCREQSDWASDVEVLGPLRPGGVAGSALVQVRVRELRKGEAERGGAGGGGKLFSLCAWDGRAWHHHGAAGGFLLRVRPRLYGPGGDLLPPAWLRALGALLLLALSALFSGLRLSLLSLDPVELRVLRNSGSAAEQEQARRVQAVRGRGTHLLCTLLLGQAGANAALAGWLYTSLPPGFGGTGEDYSEEGIHFPWLPALVCTGAVFLGAEICPYSVCSRHGLAIASHSVCLTRLLMAAAFPVCYPLGRLLDWALRQEISTFYTREKLLETLRAADPYSDLVKEELNIIQGALELRTKVVEEVLTPLGDCFMLRSDAVLDFATVSEILRSGYTRIPVYEGDQRHNIVDILFVKDLAFVDPDDCTPLLTVTRFYNRPLHCVFNDTRLDTVLEEFKKGKSHLAIVQRVNNEGEGDPFYEVMGIVTLEDIIEEIIKSEILDETDLYTDNRKKQRVPQRERKRHDFSLFKLSDTEMRVKISPQLLLATHRFMATEVEPFKSLYLSEKILLRLLKHPNVIQELKFDEKNKKAPEHYLYQRNRPVDYFVLLLQGKVEVEVGKEGLRFENGAFTYYGVPAIMTTACSDNDVRKVGSLAGSSVFLNRSPSRCSGLNRSESPNRERSDFGGSNTQLYSSSNNLYMPDYSVHILSDVQFVKITRQQYQNALTACHMDSSPQSPDMEAFTDGDSTKAPTTRGTPQTPKDDPAITLLNNRNSLPCSRSDGLRSPSEVVYLRMEELAFTQEEMTDFEEHSTQQLTLSPAAVPTRAASDSECCNINLDTETSPCSSDFEENVGKKLLRTLSGQKRKRSPEGERTSEDNSNLTPLIT
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NRU3-1; Sequence=Displayed; Name=2; IsoId=Q9NRU3-2; Sequence=VSP_027076
Alternative Sequence
842..892; CSRSDGLRSPSEVVYLRMEELAFTQEEMTDFEEHSTQQLTLSPAAVPTRAA -> S (in isoform 2)
Domain & Motif Annotations
Compositional Bias
731..740; Polar residues; 814..824; Polar residues; 942..951; Polar residues
Domain (FT)
218..414; CNNM transmembrane; 433..495; CBS 1; 502..568; CBS 2
Region
116..135; Disordered; 731..753; Disordered; 795..830; Disordered; 920..951; Disordered
Protein Families
ACDP family
Sequence Similarities
Belongs to the ACDP family.
Clinical Relevance4
Antibody
Interaction Protein (2)
ENSG00000112245ENSG00000184007
Interaction Count
2
Interaction Dataset
intact_biogrid
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 38343172 | Analysis of secreted small extracellular vesicles from activated human microglial cell lines reveals distinct pro- and anti-inflammatory proteomic profiles. | No abstract available |