Protein detail

GP173

Probable G-protein coupled receptor 173 (Super conserved receptor expressed in brain 3)

Entry name GP173	UniProt ID Q9NS66	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 7	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Probable G-protein coupled receptor 173 (Super conserved receptor expressed in brain 3)

Protein Function

G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

27..47; Helical; Name=1; 60..80; Helical; Name=2; 98..118; Helical; Name=3; 140..160; Helical; Name=4; 189..209; Helical; Name=5; 288..308; Helical; Name=6; 323..343; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000184194

Entrez Gene Symbol

GPR173

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization4

Tissue Specificadipose tissueCell SpecificAdipocytesSecretome LocationSecreted to bloodSecretome FunctionReceptor

Function & Pathway6

Protein Function

G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component

GO:0005886 plasma membrane

Molecular Function (3)

Biological Process (3)

Canonical Pathways

M264 Pid toll endogenous pathway

Mediation Categories

Other mediation

Relations & Evidence38

Ligand-Receptor Signaling (37)

37 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	HGNC	No	Yes	No	Yes	No
receptor	receptor	HPMR	No	Yes	No	Yes	No
receptor	receptor	Surfaceome	No	Yes	No	Yes	No
gpcr	receptor	DGIdb	No	Yes	No	Yes	No
gpcr	receptor	Almen2009	No	Yes	No	Yes	No
rhodopsin	receptor	Almen2009	No	Yes	No	Yes	No
gpcr	receptor	UniProt_keyword	No	Yes	No	Yes	No
seven_transmembrane_7tm	receptor	HPMR	No	Yes	No	Yes	No
7tm_a	receptor	HPMR	No	Yes	No	Yes	No
sreb_7tm_a	receptor	HPMR	No	Yes	No	Yes	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry；RNA Sequencing；Flow cytometry	1	41307968

Sequence, Structure & Domains5

Sequences

Length

373

Mass

41,481

Sequence

MANTTGEPEEVSGALSPPSASAYVKLVLLGLIMCVSLAGNAILSLLVLKERALHKAPYYFLLDLCLADGIRSAVCFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVTRYMAIAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIFEHRYFKANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMKPVQMVPAISQNWTFHGPGATGQAAANWIAGFGRGPMPPTLLGIRQNGHAASRRLLGMDEVKGEKQLGRMFYAITLLFLLLWSPYIVACYWRVFVKACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCLRTHAPCWGTGGAPAPREPYCVM

Domain & Motif Annotations

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Supporting Publications1

PMID	Title	Abstract
41216884	Extracellular Vesicles From Multiple Sclerosis White Matter Exhibit Synaptic, Mitochondrial, Complement and Ageing-Related Pathway Dysregulation.	No abstract available