Protein detail
S22AB
Solute carrier family 22 member 11 (Organic anion transporter 4) (OAT4) (Organic anion:dicarboxylate exchanger OAT4)
Entry name S22AB | UniProt ID | EVMP confidence score 0.35 |
Supporting publications (n) 0 | Transmembrane count 12 | Protein classification FDA approved drug targetsMetabolic proteinsPlasma proteinsPredicted membrane proteinsTransporters |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Solute carrier family 22 member 11 (Organic anion transporter 4) (OAT4) (Organic anion:dicarboxylate exchanger OAT4)
Protein Class (5)
FDA approved drug targetsMetabolic proteinsPlasma proteinsPredicted membrane proteinsTransporters
Protein Function (2)
- Transporters:Electrochemical Potential-driven transporters
- FDA approved drug targets:Small molecule drugs
Transmembrane
11..31; Helical; 143..163; Helical; 175..195; Helical; 201..221; Helical; 232..252; Helical; 257..277; Helical; 347..367; Helical; 379..399; Helical; 403..423; Helical; 431..451; Helical; 464..484; Helical; 491..511; Helical
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym
OAT4
Gene Description
Solute carrier family 22 member 11
Chromosome
11
Position
64555690-64572875
Supporting publications (n)
0
EVMP confidence score
0.35
Function & Pathway
Protein Function (2)
- Transporters:Electrochemical Potential-driven transporters
- FDA approved drug targets:Small molecule drugs
Cellular Component (5)
Molecular Function (5)
Reactome (4)
Mediation Categories (2)
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence24
Ligand-Receptor Signaling (23)
23 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | Yes | ||||
| extracellular | extracellular | DGIdb | |||||
| extracellular | extracellular | OmniPath | |||||
| transporter | transporter | Surfaceome | Yes | ||||
| solute_carrier | transporter | Almen2009 | Yes | ||||
| mfs | transporter | Surfaceome | Yes | ||||
| slc22 | transporter | Surfaceome | Yes | ||||
| slc | transporter | Surfaceome | Yes | ||||
| transporter | transporter | OmniPath | Yes | ||||
| transmembrane | transmembrane | UniProt_location |
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Sequence, Structure & Domains
Sequences
Length
550
Mass
59,972
Sequence
MAFSKLLEQAGGVGLFQTLQVLTFILPCLMIPSQMLLENFSAAIPGHRCWTHMLDNGSAVSTNMTPKALLTISIPPGPNQGPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRSVFTSTIVAKWDLVCSSQGLKPLSQSIFMSGILVGSFIWGLLSYRFGRKPMLSWCCLQLAVAGTSTIFAPTFVIYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSRRAVTMTVVGCAFSAGQAALGGLAFALRDWRTLQLAASVPFFAISLISWWLPESARWLIIKGKPDQALQELRKVARINGHKEAKNLTIEVLMSSVKEEVASAKEPRSVLDLFCVPVLRWRSCAMLVVNFSLLISYYGLVFDLQSLGRDIFLLQALFGAVDFLGRATTALLLSFLGRRTIQAGSQAMAGLAILANMLVPQDLQTLRVVFAVLGKGCFGISLTCLTIYKAELFPTPVRMTADGILHTVGRLGAMMGPLILMSRQALPLLPPLLYGVISIASSLVVLFFLPETQGLPLPDTIQDLESQKSTAAQGNRQEAVTVESTSL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NSA0-1; Sequence=Displayed; Name=2; IsoId=Q9NSA0-2; Sequence=VSP_018319
Alternative Sequence
353..461; NFSLLISYYGLVFDLQSLGRDIFLLQALFGAVDFLGRATTALLLSFLGRRTIQAGSQAMAGLAILANMLVPQDLQTLRVVFAVLGKGCFGISLTCLTIYKAELFPTPVR -> K (in isoform 2)
3D Structural Models
Turn
164..166
Helix
2..9; 15..35; 38..41; 52..55; 66..73; 93..95; 107..109; 128..132; 141..163; 169..186; 187..189; 193..221; 224..252; 255..275; 280..285; 289..302; 315..319; 321..326; 335..338; 340..365; 367..370; 374..398; 401..421; 427..455; 458..483; 484..487; 492..511
Beta Strand
47..49; 78..82; 84..90; 110..112; 117..119
3D Structure
Electron microscopy (3)
Domain & Motif Annotations
Region
531..550; Disordered
Protein Families (2)
- Major facilitator (TC 2.A.1) superfamily
- Organic cation transporter (TC 2.A.1.19) family
Sequence Similarities
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Clinical Relevance
Disease Involvement
FDA approved drug targets
Drug Targets
FDA approved drug targets
Drugs (3)
Antibody