Protein detail
SAMN1
SAM domain-containing protein SAMSN-1 (Hematopoietic adaptor containing SH3 and SAM domains 1) (Nash1) (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein)
Entry name SAMN1 | UniProt ID | EVMP score 0.38 |
Frequency 2 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
SAM domain-containing protein SAMSN-1 (Hematopoietic adaptor containing SH3 and SAM domains 1) (Nash1) (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
HACS1NASH1SASH2SH3D6BSLy2
Gene Description
SAM domain, SH3 domain and nuclear localization signals 1
Chromosome
21
Position
14485228-14658821
Frequency
2
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificliverCell SpecificHepatocytes
Function & Pathway
Protein Function
Predicted intracellular proteins
Molecular Function
Biological Process
Mediation Categories
Immune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | FACS | 1 | 40730843 |
Sequence, Structure & Domains
Sequences
Length
373
Mass
41,708
Sequence
MLKRKPSNVSEKEKHQKPKRSSSFGNFDRFRNNSLSKPDDSTEAHEGDPTNGSGEQSKTSNNGGGLGKKMRAISWTMKKKVGKKYIKALSEEKDEEDGENAHPYRNSDPVIGTHTEKVSLKASDSMDSLYSGQSSSSGITSCSDGTSNRDSFRLDDDGPYSGPFCGRARVHTDFTPSPYDTDSLKIKKGDIIDIICKTPMGMWTGMLNNKVGNFKFIYVDVISEEEAAPKKIKANRRSNSKKSKTLQEFLERIHLQEYTSTLLLNGYETLEDLKDIKESHLIELNIENPDDRRRLLSAAENFLEEEIIQEQENEPEPLSLSSDISLNKSQLDDCPRDSGCYISSGNSDNGKEDLESENLSDMVHKIIITEPSD
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9NSI8-1; Sequence=Displayed; Name=2; Synonyms=b; IsoId=Q9NSI8-2; Sequence=VSP_008119; Name=3; IsoId=Q9NSI8-3; Sequence=VSP_008120
Alternative Sequence
1..19; MLKRKPSNVSEKEKHQKPK -> MEIRLDTLSASLGRSSTLNNCNLEDKLAWYEGEAYMWHHWKPFPENPLWTCLDFQIAQVGPWDHCSSCIRHTRLKSSCSDMDLLHSW (in isoform 3); 19..186; Missing (in isoform 2)
3D Structural Models
Helix
216..218
Beta Strand
166..170; 191..197; 203..207; 210..214; 219..222
3D Structure
NMR spectroscopy (1)
Domain & Motif Annotations
Compositional Bias
37..48; Basic and acidic residues; 50..61; Polar residues; 123..146; Low complexity
Motif
20..25; Important for interaction with 14-3-3 proteins
Domain (FT)
163..224; SH3; 241..305; SAM
Region
1..72; Disordered; 91..153; Disordered; 337..359; Disordered