Protein detail
SAMN1
SAM domain-containing protein SAMSN-1 (Hematopoietic adaptor containing SH3 and SAM domains 1) (Nash1) (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein)
Entry name SAMN1 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 2 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
SAM domain-containing protein SAMSN-1 (Hematopoietic adaptor containing SH3 and SAM domains 1) (Nash1) (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (5)
HACS1NASH1SASH2SH3D6BSLy2
Gene Description
SAM domain, SH3 domain and nuclear localization signals 1
Chromosome
21
Position
14485228-14658821
Supporting publications (n)
2
EVMP confidence score
0.38
Fluorescence & Localization2
Tissue SpecificliverCell SpecificHepatocytes
Function & Pathway5
Protein Function
Predicted intracellular proteins
Cellular Component (4)
Molecular Function (2)
Biological Process (3)
Mediation Categories
Immune mediation
Relations & Evidence5
Ligand-Receptor Signaling (4)
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | FACS | 1 | 40730843 |
Sequence, Structure & Domains12
Sequences
Length
373
Mass
41,708
Sequence
MLKRKPSNVSEKEKHQKPKRSSSFGNFDRFRNNSLSKPDDSTEAHEGDPTNGSGEQSKTSNNGGGLGKKMRAISWTMKKKVGKKYIKALSEEKDEEDGENAHPYRNSDPVIGTHTEKVSLKASDSMDSLYSGQSSSSGITSCSDGTSNRDSFRLDDDGPYSGPFCGRARVHTDFTPSPYDTDSLKIKKGDIIDIICKTPMGMWTGMLNNKVGNFKFIYVDVISEEEAAPKKIKANRRSNSKKSKTLQEFLERIHLQEYTSTLLLNGYETLEDLKDIKESHLIELNIENPDDRRRLLSAAENFLEEEIIQEQENEPEPLSLSSDISLNKSQLDDCPRDSGCYISSGNSDNGKEDLESENLSDMVHKIIITEPSD
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9NSI8-1; Sequence=Displayed; Name=2; Synonyms=b; IsoId=Q9NSI8-2; Sequence=VSP_008119; Name=3; IsoId=Q9NSI8-3; Sequence=VSP_008120
Alternative Sequence
1..19; MLKRKPSNVSEKEKHQKPK -> MEIRLDTLSASLGRSSTLNNCNLEDKLAWYEGEAYMWHHWKPFPENPLWTCLDFQIAQVGPWDHCSSCIRHTRLKSSCSDMDLLHSW (in isoform 3); 19..186; Missing (in isoform 2)
3D Structural Models
Helix
216..218
Beta Strand
166..170; 191..197; 203..207; 210..214; 219..222
3D Structure
NMR spectroscopy (1)
Domain & Motif Annotations
Compositional Bias
37..48; Basic and acidic residues; 50..61; Polar residues; 123..146; Low complexity
Motif
20..25; Important for interaction with 14-3-3 proteins
Domain (FT)
163..224; SH3; 241..305; SAM
Region
1..72; Disordered; 91..153; Disordered; 337..359; Disordered
Supporting Publications2
| PMID | Title | Abstract |
|---|---|---|
| 22490681 | Maturing reticulocytes internalize plasma membrane in glycophorin A-containing vesicles that fuse with autophagosomes before exocytosis. | Early reticulocyte maturation is characterized by the selective elimination of unwanted plasma membrane proteins (CD71, CD98, and β1 integrin) through the endosome-exosome pathway. |
| 36973758 | The glycoprotein CD147 defines miRNA-enriched extracellular vesicles that derive from cancer cells. | No abstract available |