Protein detail
ATG3
Ubiquitin-like-conjugating enzyme ATG3 (EC 2.3.2.-) (Autophagy-related protein 3) (APG3-like) (hApg3) (Protein PC3-96)
Protein symbol ATG3 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Predicted intracellular proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Ubiquitin-like-conjugating enzyme ATG3 (EC 2.3.2.-) (Autophagy-related protein 3) (APG3-like) (hApg3) (Protein PC3-96)
Protein Class
Predicted intracellular proteinsTransporters
Protein Function
- Transporters
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
APG3LDKFZp564M1178FLJ22125MGC15201PC3-96
Gene Description
Autophagy related 3
Chromosome
3
Position
112532510-112562046
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificDifferentiating spermatogoniaSingle-Nuclei Brain Specificvascular associated smooth muscle cell
Function & Pathway
Protein Function
- Transporters
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Mediation Categories
Fusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
5 records.
Protein Complex Composition
22 records.
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Sequence, Structure & Domains
Sequences
Length
314
Mass
35,864
Sequence
MQNVINTVKGKALEVAEYLTPVLKESKFKETGVITPEEFVAAGDHLVHHCPTWQWATGEELKVKAYLPTGKQFLVTKNVPCYKRCKQMEYSDELEAIIEEDDGDGGWVDTYHNTGITGITEAVKEITLENKDNIRLQDCSALCEEEEDEDEGEAADMEEYEESGLLETDEATLDTRKIVEACKAKTDAGGEDAILQTRTYDLYITYDKYYQTPRLWLFGYDEQRQPLTVEHMYEDISQDHVKKTVTIENHPHLPPPPMCSVHPCRHAEVMKKIIETVAEGGGELGVHMYLLIFLKFVQAVIPTIEYDYTRHFTM
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NT62-1; Sequence=Displayed; Name=2; IsoId=Q9NT62-2; Sequence=VSP_013037
Alternative Sequence
290..314; LLIFLKFVQAVIPTIEYDYTRHFTM -> PSLYVRLVAKWLLTIFFLRNLV (in isoform 2)
3D Structural Models
Turn
28..31; 208..211; 242..244
Helix
36..49; 69..71; 157..163; 229..232; 233..235; 238..241; 267..278; 286..288; 289..298
Beta Strand
54..56; 72..79; 97..99; 101..105; 107..109; 199..207; 212..220; 245..248; 251..253; 258..261
3D Structure
NMR spectroscopy (1); X-ray crystallography (3)
Domain & Motif Annotations
Motif
4..19; Membrane-curvature-sensing motif; 101..103; Increases ATG3 translation efficiency by the ribosome assisted of EIF5A; 104..110; LIR motif; 166..169; Caspase cleavage motif LETD
Domain (CC)
The N-terminal region works in concert with its geometry-selective amphipathic helix (AH) to promote LC3-PE conjugation activity only on the target membrane.; DOMAIN: The LC3 interacting regions (LIR) motif mediates interaction with GABARAP and MAP1LC3A in a beta-sheet conformation-dependent manner (PubMed:37252361). The LIR motif is required for LC3 lipidation and ATG3~LC3 thioester formation (PubMed:37252361).; DOMAIN: The membrane-curvature-sensing motif targets curved membranes.
Region
140..170; Interaction with ATG12; 143..163; Disordered
Protein Families
ATG3 family
Sequence Similarities
Belongs to the ATG3 family.