Protein detail
AT8A2
Phospholipid-transporting ATPase IB (EC 7.6.2.1) (ATPase class I type 8A member 2) (ML-1) (P4-ATPase flippase complex alpha subunit ATP8A2)
Protein symbol AT8A2 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 10 | Protein classification Disease related genesEnzymesHuman disease related genesPotential drug targetsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Phospholipid-transporting ATPase IB (EC 7.6.2.1) (ATPase class I type 8A member 2) (ML-1) (P4-ATPase flippase complex alpha subunit ATP8A2)
Protein Class
Disease related genesEnzymesHuman disease related genesPotential drug targetsPredicted membrane proteins
Protein Function
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Potential drug targets
- Enzymes
- ENZYME proteins
- Disease related genes
Transmembrane
95..115; Helical; 120..140; Helical; 317..337; Helical; 365..385; Helical; 888..908; Helical; 911..931; Helical; 960..980; Helical; 998..1018; Helical; 1029..1049; Helical; 1064..1084; Helical
Transmembrane Count
10
Ensembl
Entrez Gene Symbol
Gene Synonym
ATPIBML-1
Gene Description
ATPase phospholipid transporting 8A2
Chromosome
13
Position
25371974-26025851
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificAdipocytesSingle-Nuclei Brain SpecificastrocyteSecretome LocationSecreted to extracellular matrixSecretome FunctionNo annotated function
Function & Pathway
Protein Function
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Potential drug targets
- Enzymes
- ENZYME proteins
- Disease related genes
Cellular Component
Molecular Function
- GO:0000287 magnesium ion binding
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0016887 ATP hydrolysis activity
- GO:0090555 phosphatidylethanolamine flippase activity
- GO:0090556 phosphatidylserine floppase activity
- GO:0140326 ATPase-coupled intramembrane lipid transporter activity
- GO:0140346 phosphatidylserine flippase activity
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
14 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 28914500 |
Sequence, Structure & Domains
Sequences
Length
1,188
Mass
133,599
Sequence
MLNGAGLDKALKMSLPRRSRIRSSVGPVRSSLGYKKAEDEMSRATSVGDQLEAPARTIYLNQPHLNKFRDNQISTAKYSVLTFLPRFLYEQIRRAANAFFLFIALLQQIPDVSPTGRYTTLVPLIIILTIAGIKEIVEDFKRHKADNAVNKKKTIVLRNGMWHTIMWKEVAVGDIVKVVNGQYLPADVVLLSSSEPQAMCYVETANLDGETNLKIRQGLSHTADMQTREVLMKLSGTIECEGPNRHLYDFTGNLNLDGKSLVALGPDQILLRGTQLRNTQWVFGIVVYTGHDTKLMQNSTKAPLKRSNVEKVTNVQILVLFGILLVMALVSSAGALYWNRSHGEKNWYIKKMDTTSDNFGYNLLTFIILYNNLIPISLLVTLEVVKYTQALFINWDTDMYYIGNDTPAMARTSNLNEELGQVKYLFSDKTGTLTCNIMNFKKCSIAGVTYGHFPELAREPSSDDFCRMPPPCSDSCDFDDPRLLKNIEDRHPTAPCIQEFLTLLAVCHTVVPEKDGDNIIYQASSPDEAALVKGAKKLGFVFTARTPFSVIIEAMGQEQTFGILNVLEFSSDRKRMSVIVRTPSGRLRLYCKGADNVIFERLSKDSKYMEETLCHLEYFATEGLRTLCVAYADLSENEYEEWLKVYQEASTILKDRAQRLEECYEIIEKNLLLLGATAIEDRLQAGVPETIATLLKAEIKIWVLTGDKQETAINIGYSCRLVSQNMALILLKEDSLDATRAAITQHCTDLGNLLGKENDVALIIDGHTLKYALSFEVRRSFLDLALSCKAVICCRVSPLQKSEIVDVVKKRVKAITLAIGDGANDVGMIQTAHVGVGISGNEGMQATNNSDYAIAQFSYLEKLLLVHGAWSYNRVTKCILYCFYKNVVLYIIELWFAFVNGFSGQILFERWCIGLYNVIFTALPPFTLGIFERSCTQESMLRFPQLYKITQNGEGFNTKVFWGHCINALVHSLILFWFPMKALEHDTVLTSGHATDYLFVGNIVYTYVVVTVCLKAGLETTAWTKFSHLAVWGSMLTWLVFFGIYSTIWPTIPIAPDMRGQATMVLSSAHFWLGLFLVPTACLIEDVAWRAAKHTCKKTLLEEVQELETKSRVLGKAVLRDSNGKRLNERDRLIKRLGRKTPPTLFRGSSLQQGVPHGYAFSQEEHGAVSQEEVIRAYDTTKKKSRKK
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=3; IsoId=Q9NTI2-4; Sequence=Displayed; Name=1; IsoId=Q9NTI2-1; Sequence=VSP_059718; Name=2; IsoId=Q9NTI2-3; Sequence=VSP_059718, VSP_059719, VSP_059720
Alternative Sequence
1..40; Missing (in isoform 1 and isoform 2); 555..568; MGQEQTFGILNVLE -> VSNMRVHISDHLLL (in isoform 2); 569..1188; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
1163..1182; Basic and acidic residues
Region
1162..1188; Disordered
Protein Families
- Cation transport ATPase (P-type) (TC 3.A.3) family
- Type IV subfamily
Sequence Similarities
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.