Protein detail
RN146
E3 ubiquitin-protein ligase RNF146 (EC 2.3.2.27) (Dactylidin) (Iduna) (RING finger protein 146) (RING-type E3 ubiquitin transferase RNF146)
Entry name RN146 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Disease related genesEnzymesMetabolic proteinsPotential drug targetsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
E3 ubiquitin-protein ligase RNF146 (EC 2.3.2.27) (Dactylidin) (Iduna) (RING finger protein 146) (RING-type E3 ubiquitin transferase RNF146)
Protein Class
Disease related genesEnzymesMetabolic proteinsPotential drug targetsPredicted intracellular proteins
Protein Function
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym
dactylidindJ351K20.1DKFZp434O1427
Gene Description
Ring finger protein 146
Chromosome
6
Position
127266726-127288567
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificEndometrial glandular cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificnaive CD4 T-cellBlood Lineage SpecificT-cellsSecretome LocationSecreted to bloodSecretome FunctionReceptor
Function & Pathway
Protein Function
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Disease related genes
Cellular Component
Molecular Function
Biological Process
Reactome
- R-hsa-4641257 degradation of axin
- R-hsa-5688426 deubiquitination
- R-hsa-9006925 intracellular signaling by second messengers
- R-hsa-597592 post translational protein modification
- R-hsa-6807070 pten regulation
- R-hsa-8948751 regulation of pten stability and activity
- R-hsa-195721 signaling by wnt
- R-hsa-201681 tcf dependent signaling in response to wnt
- R-hsa-5689880 ub specific processing proteases
Mediation Categories
Metabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
143 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| RN146 | Q9NTX7 | CASC3 | O15234 | Yes | No | Yes | SIGNOR | SIGNOR:21478859 |
| RN146 | Q9NTX7 | TNKS2 | Q9H2K2 | Yes | No | Yes | SIGNORACSN | ACSN:21478859ACSN:19759537ACSN:21799911ACSN:22274711SIGNOR:21799911 |
| RN146 | Q9NTX7 | TNKS1 | O95271 | Yes | No | Yes | SIGNORHINTACSNIntActDIP | ACSN:17825467ACSN:21478859DIP:25327252HINT:21799911ACSN:19759537ACSN:22154485ACSN:21799911ACSN:22274711HINT:25327252IntAct:25327252HINT:29604130HINT:32698014SIGNOR:21799911 |
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Protein Complex Composition
6 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| Ub:RING_E3 | RNF146UBB | P0CG47Q9NTX7 | 0:0 | SIGNOR | SIGNOR:SIGNOR-C519 | |
| Ub:RING_E3 | RNF146UBC | P0CG48Q9NTX7 | 0:0 | SIGNOR | SIGNOR:SIGNOR-C519 | |
| Ub:RING_E3 | RNF146RPS27A | P62979Q9NTX7 | 0:0 | SIGNOR | SIGNOR:SIGNOR-C519 | |
| Ub:RING_E3 | RNF146UBA52 | P62987Q9NTX7 | 0:0 | SIGNOR | SIGNOR:SIGNOR-C519 | |
| CHD1LRNF146 | Q86WJ1Q9NTX7 | 0:0 | hu.MAPhu.MAP2 | |||
| RNF146 | Q9NTX7 | 2 | PDB | PDB:3v3l |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture | Western blotting | 1 | 40098346 |
Sequence, Structure & Domains
Sequences
Length
359
Mass
38,950
Sequence
MMAGCGEIDHSINMLPTNRKANESCSNTAPSLTVPECAICLQTCVHPVSLPCKHVFCYLCVKGASWLGKRCALCRQEIPEDFLDKPTLLSPEELKAASRGNGEYAWYYEGRNGWWQYDERTSRELEDAFSKGKKNTEMLIAGFLYVADLENMVQYRRNEHGRRRKIKRDIIDIPKKGVAGLRLDCDANTVNLARESSADGADSVSAQSGASVQPLVSSVRPLTSVDGQLTSPATPSPDASTSLEDSFAHLQLSGDNTAERSHRGEGEEDHESPSSGRVPAPDTSIEETESDASSDSEDVSAVVAQHSLTQQRLLVSNANQTVPDRSDRSGTDRSVAGGGTVSVSVRSRRPDGQCTVTEV
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NTX7-1; Sequence=Displayed; Name=2; IsoId=Q9NTX7-2; Sequence=VSP_012968
Alternative Sequence
1; Missing (in isoform 2)
3D Structural Models
Turn
51..53; 149..152
Helix
58..63; 80..83; 119..130
Beta Strand
30..33; 38..43; 45..50; 54..57; 68..70; 72..74; 104..109; 111..116; 134..140; 143..148; 153..159; 164..173
3D Structure
NMR spectroscopy (1); X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
284..298; Acidic residues; 306..323; Polar residues
Zinc Finger
37..75; RING-type
Domain (CC)
The WWE domain mediates non-covalent PAR-binding.
Domain (FT)
92..168; WWE
Region
254..359; Disordered