Protein detail
EXOC1
Exocyst complex component 1 (Exocyst complex component Sec3)
Entry name EXOC1 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 5 | Transmembrane count | Protein classification Essential proteinsPredicted intracellular proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Exocyst complex component 1 (Exocyst complex component Sec3)
Protein Class (3)
Essential proteinsPredicted intracellular proteinsTransporters
Protein Function (2)
- Transporters:Transporter channels and pores
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (5)
BM-102FLJ10893SEC3SEC3L1Sec3p
Gene Description
Exocyst complex component 1
Chromosome
4
Position
55853648-55905086
Supporting publications (n)
5
EVMP confidence score
0.50
Fluorescence & Localization1
Function & Pathway5
Protein Function (2)
- Transporters:Transporter channels and pores
- Predicted intracellular proteins
Cellular Component (7)
Molecular Function (2)
Reactome (14)
- R-hsa-5620920 cargo trafficking to the periciliary membrane
- R-hsa-5617833 cilium assembly
- R-hsa-9920588 dengue virus activates modulates innate and adaptive immune responses
- R-hsa-9918481 dengue virus host interactions
- R-hsa-9839923 dengue virus infection
- R-hsa-5663205 infectious disease
- R-hsa-264876 insulin processing
- R-hsa-199991 membrane trafficking
- R-hsa-1852241 organelle biogenesis and maintenance
- R-hsa-2980736 peptide hormone metabolism
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Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence11
Ligand-Receptor Signaling (6)
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Protein Complex Composition (4)
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CDC5LEXOC1EXOC2SNW1UBC | P0CG48Q13573Q96KP1Q99459Q9NV70 | 1:1:1:1:1 | CompleatCFinder | Compleat:HC4724 | ||
| EXOC1IQCB1NCKAP5L | Q15051Q9HCH0Q9NV70 | 0:0:0 | hu.MAP2 | |||
| EXOC1FKBP15NCKAP5L | Q5T1M5Q9HCH0Q9NV70 | 0:0:0 | hu.MAP2 | |||
| EXOC1NCKAP5L | Q9HCH0Q9NV70 | 0:0 | hu.MAP2 |
Sequence, Structure & Domains10
Sequences
Length
894
Mass
101,982
Sequence
MTAIKHALQRDIFTPNDERLLSIVNVCKAGKKKKNCFLCATVTTERPVQVKVVKVKKSDKGDFYKRQIAWALRDLAVVDAKDAIKENPEFDLHFEKIYKWVASSTAEKNAFISCIWKLNQRYLRKKIDFVNVSSQLLEESVPSGENQSVTGGDEEVVDEYQELNAREEQDIEIMMEGCEYAISNAEAFAEKLSRELQVLDGANIQSIMASEKQVNILMKLLDEALKEVDQIELKLSSYEEMLQSVKEQMDQISESNHLIHLSNTNNVKLLSEIEFLVNHMDLAKGHIKALQEGDLASSRGIEACTNAADALLQCMNVALRPGHDLLLAVKQQQQRFSDLRELFARRLASHLNNVFVQQGHDQSSTLAQHSVELTLPNHHPFHRDLLRYAKLMEWLKSTDYGKYEGLTKNYMDYLSRLYEREIKDFFEVAKIKMTGTTKESKKFATLPRKESAVKQETESLHGSSGKLTGSTSSLNKLSVQSSGNRRSQSSSLLDMGNMSASDLDVADRTKFDKIFEQVLSELEPLCLAEQDFISKFFKLQQHQSMPGTMAEAEDLDGGTLSRQHNCGTPLPVSSEKDMIRQMMIKIFRCIEPELNNLIALGDKIDSFNSLYMLVKMSHHVWTAQNVDPASFLSTTLGNVLVTVKRNFDKCISNQIRQMEEVKISKKSKVGILPFVAEFEEFAGLAESIFKNAERRGDLDKAYTKLIRGVFVNVEKVANESQKTPRDVVMMENFHHIFATLSRLKISCLEAEKKEAKQKYTDHLQSYVIYSLGQPLEKLNHFFEGVEARVAQGIREEEVSYQLAFNKQELRKVIKEYPGKEVKKGLDNLYKKVDKHLCEEENLLQVVWHSMQDEFIRQYKHFEGLIARCYPGSGVTMEFTIQDILDYCSSIAQSH
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NV70-1; Sequence=Displayed; Name=2; IsoId=Q9NV70-2; Sequence=VSP_001481
Alternative Sequence
444..459; ATLPRKESAVKQETES -> G (in isoform 2)
Domain & Motif Annotations
Compositional Bias
439..459; Basic and acidic residues; 460..491; Low complexity
Coiled Coil
152..174; 205..259
Region
439..495; Disordered
Protein Families
SEC3 family
Sequence Similarities
Belongs to the SEC3 family.
Clinical Relevance4
Interaction Protein (19)
ENSG00000032389ENSG00000070367ENSG00000099940ENSG00000100505ENSG00000112685ENSG00000116903ENSG00000119401ENSG00000131558ENSG00000138190ENSG00000138750ENSG00000143228ENSG00000143553ENSG00000144036ENSG00000144674ENSG00000155980ENSG00000173226ENSG00000177548ENSG00000180104ENSG00000182473
Interaction Count
19
Interaction Dataset
intact_biogrid
Supporting Publications4
| PMID | Title | Abstract |
|---|---|---|
| 23161513 | Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS. | Exosomes from mutant KRAS cells contain many tumor-promoting proteins, including KRAS, EGFR, SRC family kinases, and integrins. |
| 28396511 | Database-augmented Mass Spectrometry Analysis of Exosomes Identifies Claudin 3 as a Putative Prostate Cancer Biomarker. | No abstract available |
| 32795414 | Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. | Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers. |
| 41216884 | Extracellular Vesicles From Multiple Sclerosis White Matter Exhibit Synaptic, Mitochondrial, Complement and Ageing-Related Pathway Dysregulation. | No abstract available |