Protein detail

UQCC1

Ubiquinol-cytochrome c reductase complex assembly factor 1 (Basic FGF-repressed Zic-binding protein) (bFGF-repressed Zic-binding protein) (bFZb) (Ubiquinol-cytochrome c reductase complex chaperone CBP3 homolog)

Entry name UQCC1	UniProt ID Q9NVA1	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count	Protein classification Plasma proteinsPredicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Protein Class (3)

Plasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000101019

Entrez Gene Symbol

UQCC1

Gene Synonym (5)

BFZBC20orf44CBP3FLJ10850UQCC

Gene Description

Ubiquinol-cytochrome c reductase complex assembly factor 1

Chromosome

Position

35302566-35412031

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization2

Cell SpecificChoroid plexus epithelial cells

Function & Pathway5

Protein Function

Predicted intracellular proteins

Cellular Component (3)

Molecular Function

GO:0005515 protein binding

Reactome (3)

Mediation Categories

Metabolism mediation

Relations & Evidence10

Ligand-Receptor Signaling (7)

7 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No

Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	COX20 UQCC1 UQCC2 UQCC4	Q4G0I0 Q5RI15 Q9BRT2 Q9NVA1	0:0:0:0	hu.MAP
	UQCC1 UQCC2	Q9BRT2 Q9NVA1	0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	2	35212939 27894104

Sequence, Structure & Domains7

Sequences

Length

299

Mass

34,600

Sequence

MALLVRVLRNQTSISQWVPVCSRLIPVSPTQGQGDRALSRTSQWPQMSQSRACGGSEQIPGIDIQLNRKYHTTRKLSTTKDSPQPVEEKVGAFTKIIEAMGFTGPLKYSKWKIKIAALRMYTSCVEKTDFEEFFLRCQMPDTFNSWFLITLLHVWMCLVRMKQEGRSGKYMCRIIVHFMWEDVQQRGRVMGVNPYILKKNMILMTNHFYAAILGYDEGILSDDHGLAAALWRTFFNRKCEDPRHLELLVEYVRKQIQYLDSMNGEDLLLTGEVSWRPLVEKNPQSILKPHSPTYNDEGL

Alternative Products

Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q9NVA1-1; Sequence=Displayed; Name=2; IsoId=Q9NVA1-2; Sequence=VSP_000857; Name=3; IsoId=Q9NVA1-3; Sequence=VSP_000855, VSP_000856; Name=4; IsoId=Q9NVA1-4; Sequence=VSP_016027; Name=5; IsoId=Q9NVA1-5; Sequence=VSP_043406

Alternative Sequence

1..112; Missing (in isoform 3); 44..111; Missing (in isoform 5); 109..135; Missing (in isoform 4); 113..136; IKIAALRMYTSCVEKTDFEEFFLR -> MQPIDTCVSYPRTGSVSHFPG (in isoform 3); 192..217; Missing (in isoform 2)

Domain & Motif Annotations

Protein Families

CBP3 family

Sequence Similarities

Belongs to the CBP3 family.

Clinical Relevance4

Antibody

HPA034875

Interaction Protein

ENSG00000137288

Interaction Count

Interaction Dataset

intact_biogrid_bioplex

Supporting Publications1

PMID	Title	Abstract
33919183	Multiple-Cycle Polymeric Extracellular Vesicle Precipitation and Its Evaluation by Targeted Mass Spectrometry.	No abstract available